nfkb-p65

 

Enhancing the Analytical toolbox to analyze co-purifying Host Cell Proteins presence: N-(4)-(β-acetylglucosaminyl)-L-asparaginase case research

 

 

Ranges of host cell proteins (HCP) in purification intermediates and drug substances (DS) of monoclonal antibodies (mAb) should be rigorously monitored for the manufacturing of secure and efficacious biotherapeutics. In the course of the improvement of mAb1, an IgG1 product, sudden outcomes generated with HCP ELISA equipment triggered an investigation which led to the identification of a co-purifying HCP known as N-(4)-(β-acetylglucosaminyl)-L-asparaginase (AGA, EC3.5.1.26) by LC-MS/MS.

The danger evaluation carried out indicated a low immunogenicity danger for the co-purifying HCP and an ad-hoc stability research demonstrated no mAb glycan cleavage and thus no influence on product high quality.

 

 

DOCK2 {couples} with LEF-1 to control B cell metabolism and reminiscence

 

Dedicator of cytokinesis 2 (DOCK2) is important for the B cell differentiation, BCR signaling and humoral immune response.

 

 

Fractionation research carried out on sharpening steps revealed that AGA was co-eluted with the mAb. Very apparently, the native digestion protocol carried out to go deeper within the MS HCP profiling was discovered to be incompatible with correct AGA detection in final purification intermediate and DS, additional suggesting a hitchhiking conduct of AGA. In silico floor characterization of AGA additionally helps this speculation. Lastly, the mixed assist of HCP ELISA outcomes and mass spectrometry allowed course of optimization and removing of this co-purifying HCP. This text is protected by copyright. All rights reserved.
Key phrases: AGA N-(4)-(β-acetylglucosaminyl)-L-asparaginase; HCP ELISA assay; HCP identification and quantitation by LC-MS/MS; Hitchhiking conduct; Host Cell Proteins; Threat evaluation.

 

Nevertheless, the function of DOCK2 within the reminiscence response of B cell is unknown.

 

 

 

Through the use of two DOCK2 poor sufferers, we discovered that the reminiscence B cells have been decreased and the early activation of DOCK2 poor reminiscence B cells was abolished to the diploma of naïve B cells as a result of decreased expression of CD19 and CD21 mechanistically.

 

 

 

 

 

Apparently the expression of LEF-1, a adverse regulator of CD21, was elevated in DOCK2 poor B cells.

 

 

 

 

 

This was linked to the elevated expression of HIF-1α and cell metabolism, which in flip affected the ER construction.

 

nfkb-p65

nfkb-p65

 

 

Lastly, the discount of reminiscence B cells in DOCK2 sufferers was as a result of elevated apoptosis, which may be associated with the elevated metabolism.

 

 

Identification of Retinal Ganglion Cells from β-III Stained Fluorescent Microscopic Photos

 

 

Optic nerve crush in mouse mannequin is broadly used for investigating the course following retinal ganglion cell (RGCs) damage.
Handbook cell counting from β-III tubulin stained microscopic photographs has been routinely carried out to watch RGCs after an optic nerve crush damage, however is time-consuming and susceptible to observer variability.

Mouse Ig fraction

31R-1040 10 mg
EUR 180
Description: Purified Mouse Ig fraction for use as a control or blocking reagent

Sheep Ig fraction

31R-1047 10 mg
EUR 136.8
Description: Purified Sheep Ig fraction for use as a control or blocking reagent

Bovine Ig fraction

31R-1001 10 mg
EUR 136.8
Description: Bovine Ig fraction control or blocking reagent

Rabbit Ig fraction

31R-1018 10 mg
EUR 136.8
Description: Rabbit Ig fraction control or blocking reagent

Bovine Ig fraction

31R-1025 10 mg
EUR 136.8
Description: Purified Bovine Ig fraction for use as a control or blocking reagent

Rabbit Ig fraction

31R-1042 10 mg
EUR 136.8
Description: Purified Rabbit Ig fraction for use as a control or blocking reagent

Chicken Ig fraction

31R-1004 10 mg
EUR 248.4
Description: Chicken Ig fraction control or blocking reagent

Hamster Ig fraction

31R-1009 10 mg
EUR 165.6
Description: Hamster Ig fraction control or blocking reagent

Chicken Ig fraction

31R-1028 10 mg
EUR 248.4
Description: Purified Chicken Ig fraction for use as a control or blocking reagent

Guinea Pig Ig fraction

31R-1007 10 mg
EUR 138
Description: Guinea Pig Ig fraction control or blocking reagent

Guinea Pig Ig fraction

31R-1031 10 mg
EUR 165.6
Description: Purified Guinea Pig Ig fraction for use as a control or blocking reagent

BSA Fraction V (pH 5.2)

AK8245-0100 100g Ask for price

BSA Fraction V (pH 5.2)

AK8245-0500 500g Ask for price

BSA Fraction V (pH 5.2)

AK8245-1000 1kg Ask for price

BSA Fraction V (pH 7.0)

AK8905-0100 100g Ask for price

BSA Fraction V (pH 7.0)

AK8905-0500 500g Ask for price

BSA Fraction V (pH 7.0)

AK8905-1000 1kg Ask for price

AFP antibody (Ig fraction)

70R-14345 1 ml
EUR 166.8
Description: Goat polyclonal AFP antibody (Ig fraction)

Albumin, Cohn fraction pH5.2

AR2440 50g
EUR 180.06

FITC antibody (IgG fraction)

20C-CR1056SP 1 ml
EUR 289.2
Description: Rabbit polyclonal FITC antibody

Fraction Column Dufton 150mm

QFC112 EACH
EUR 140.4

Fraction Column Dufton 300mm

QFC122 EACH
EUR 157.2

WSE-7422 EzSubcell Fraction

2332338 1unit
EUR 477.6
Description: Fr act i onat i on of N ucl ei & M i t ochondr i a

Fraction V BSA 10% solution

30R-AB022 2x10ml
EUR 232.8
Description: Bovine Serum Albumin, Crohn Fraction V 10% solution

Fibrinogen antibody (IgG fraction)

20R-1420 1 liter Ask for price
Description: Goat polyclonal Human Fibrinogen antibody (IgG fraction)

Fraction V BSA powder, pH 7

BAC62-0050 50gm
EUR 407.16

Fraction V BSA powder, pH 7

BAC62-0100 100gm
EUR 489.84

Fraction V BSA powder, pH 7

BAC62-0500 500gm
EUR 702

Fraction V BSA powder, pH 7

BAC62-1000 1KG
EUR 1014

Fraction V BSA powder, pH 7

BAC62-10000 10KG Ask for price

Fraction V BSA powder, pH 5.2

BAC63-0050 50gm
EUR 407.16

Fraction V BSA powder, pH 5.2

BAC63-0100 100gm
EUR 489.84

Fraction V BSA powder, pH 5.2

BAC63-0500 500gm
EUR 702

Fraction V BSA powder, pH 5.2

BAC63-1000 1KG
EUR 1014

Fraction V BSA powder, pH 5.2

BAC63-10000 10KG Ask for price

Rat Brain Lysate Membrane Fraction

IRTBRTLM100UG each
EUR 870
Description: Rat Brain Lysate Membrane Fraction

Human Skin Lysate Membrane Fraction

IHUSKNTLM100UG each
EUR 870
Description: Human Skin Lysate Membrane Fraction

Human Lung Lysate Membrane Fraction

IHULGTLM100UG each
EUR 914
Description: Human Lung Lysate Membrane Fraction

Human Albumin antibody (IgG fraction)

20-1001 1 L Ask for price
Description: Goat polyclonal Human Albumin antibody

Mouse Brain Lysate Membrane Fraction

IMSBRTLM100UG each
EUR 870
Description: Mouse Brain Lysate Membrane Fraction

Human Heart Lysate Membrane Fraction

IHUHTTLM100UG each
EUR 870
Description: Human Heart Lysate Membrane Fraction

Human Ileum Lysate Membrane Fraction

IHUILMTLM100UG each
EUR 870
Description: Human Ileum Lysate Membrane Fraction

Human Ovary Lysate Membrane Fraction

IHUOVTLM100UG each
EUR 1610
Description: Human Ovary Lysate Membrane Fraction

Human Colon Lysate Membrane Fraction

IHUCLNTLM100UG each
EUR 1246
Description: Human Colon Lysate Membrane Fraction

Human Liver Lysate Membrane Fraction

IHULRTLM100UG each
EUR 870
Description: Human Liver Lysate Membrane Fraction

Hexane fraction, GlenDry™, anhydrous

GS2256-1 1
EUR 76.4

Hexane fraction, GlenDry™, anhydrous

GS2256-100 100
EUR 53.2

Hexane fraction, GlenDry™, anhydrous

GS2256-2500 2500
EUR 136.5

Hexane fraction, GlenDry™, anhydrous

GS2256-500 500
EUR 62.4

Human Brain Lysate Membrane Fraction

IHUBRTLM100UG each
EUR 870
Description: Human Brain Lysate Membrane Fraction

Pyruvate Kinase antibody (IgG fraction)

20R-PG010 1 ml
EUR 282
Description: Goat polyclonal Pyruvate Kinase antibody (IgG fraction)

Pyruvate Kinase antibody (IgG fraction)

20C-CR7017GP 1 mL
EUR 282
Description: Goat polyclonal Pyruvate Kinase antibody (IgG fraction)

Human Testis Lysate Membrane Fraction

IHUTSTTLM100UG each
EUR 870
Description: Human Testis Lysate Membrane Fraction

Human Thymus Lysate Membrane Fraction

IHUTYMTLM100UG each
EUR 1610
Description: Human Thymus Lysate Membrane Fraction

Human Uterus Lysate Membrane Fraction

IHUUTETLM100UG each
EUR 870
Description: Human Uterus Lysate Membrane Fraction

Human Tonsil Lysate Membrane Fraction

IHUTONTLM100UG each
EUR 1413
Description: Human Tonsil Lysate Membrane Fraction

Human Spleen Lysate Membrane Fraction

IHUSPTLM100UG each
EUR 870
Description: Human Spleen Lysate Membrane Fraction

Human Kidney Lysate Membrane Fraction

IHUKDTLM100UG each
EUR 870
Description: Human Kidney Lysate Membrane Fraction

Human Rectum Lysate Membrane Fraction

IHURCTTLM100UG each
EUR 870
Description: Human Rectum Lysate Membrane Fraction

Heptane fraction, GlenDry™, anhydrous

GS8770-1 1
EUR 76.5

Heptane fraction, GlenDry™, anhydrous

GS8770-100 100
EUR 53.2

Heptane fraction, GlenDry™, anhydrous

GS8770-2500 2500
EUR 137.4

Heptane fraction, GlenDry™, anhydrous

GS8770-500 500
EUR 63

Human Artery Lysate Membrane Fraction

IHUARTLM100UG each
EUR 1413
Description: Human Artery Lysate Membrane Fraction

Human Breast Lysate Membrane Fraction

IHUBTTLM100UG each
EUR 870
Description: Human Breast Lysate Membrane Fraction

Human Vaginal Lysate Membrane Fraction

IHUVAGTLM100UG each
EUR 870
Description: Human Vaginal Lysate Membrane Fraction

Human Adipose Lysate Membrane Fraction

IHUADPTTLM100UG each
EUR 1413
Description: Human Adipose Lysate Membrane Fraction

Human Thyroid Lysate Membrane Fraction

IHUTRTLM100UG each
EUR 870
Description: Human Thyroid Lysate Membrane Fraction

Human Skin Lysate Cytoplasmic Fraction

IHUSKNTLCYT100UG each
EUR 393
Description: Human Skin Lysate Cytoplasmic Fraction

Human Stomach Lysate Membrane Fraction

IHUSTTLM100UG each
EUR 870
Description: Human Stomach Lysate Membrane Fraction

Human Trachea Lysate Membrane Fraction

IHUTCATLM100UG each
EUR 870
Description: Human Trachea Lysate Membrane Fraction

Human Jejunum Lysate Membrane Fraction

IHUJEJTLM100UG each
EUR 870
Description: Human Jejunum Lysate Membrane Fraction
This paper describes an automated approach for RGC identification. We developed and validated (i) a delicate cell candidate segmentation scheme and (ii) a classifier that eliminated false positives whereas retaining true positives.
Two main contributions have been made in cell candidate segmentation. First, a homomorphic filter was designed to regulate for the inhomogeneous illumination attributable to uneven penetration of β-III tubulin antibody.
Second, the optimum segmentation parameters for cell detection are extremely image-specific.
To handle this problem, we launched an offline-online parameter tuning strategy.
Offline tuning optimized mannequin parameters primarily based on coaching photographs and on-line tuning additional optimized the parameters on the testing stage without having entry to the bottom fact.
Within the cell identification stage, 31 geometric, statistical and textural options have been extracted from every segmented cell candidate, which was subsequently categorised as true or false positives by assist vector machine.
The homomorphic filter and the web parameter tuning strategy collectively elevated cell recall by 28%.
The complete pipeline attained a recall, precision and coefficient of dedication (r2) of 85.3%, 97.1% and 0.994.

CD48 Antibody (Pan Leukocyte Marker)

V9323-20UG 20ug
EUR 153.3
Description: Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.

CD48 Antibody (Pan Leukocyte Marker)

V9323SAF-100UG 100ug
EUR 349.3
Description: Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.

CD48 Antibody (Pan Leukocyte Marker)

V3016-100UG 100 ug
EUR 349.3
Description: Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.

CD48 Antibody (Pan Leukocyte Marker)

V3016-20UG 20 ug
EUR 153.3
Description: Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.

CD48 Antibody (Pan Leukocyte Marker)

V3016SAF-100UG 100 ug
EUR 349.3
Description: Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.

CD48 Antibody (Pan Leukocyte Marker)

V3017-100UG 100 ug
EUR 349.3
Description: Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of the markers for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.

CD48 Antibody (Pan Leukocyte Marker)

V3017-20UG 20 ug
EUR 153.3
Description: Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of the markers for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.

CD48 Antibody (Pan Leukocyte Marker)

V3017SAF-100UG 100 ug
EUR 349.3
Description: Reacts with human CD48, a 45kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of the markers for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.

Monoclonal CD48 (Pan Leukocyte Marker) Antibody - With BSA and Azide, Clone: 5-4.8

AMM01590G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD48 (Pan Leukocyte Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone 5-4.8. This antibody is applicable in IF, FC

Monoclonal CD48 (Pan Leukocyte Marker) Antibody - With BSA and Azide, Clone: 156-4H9

AMM01588G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD48 (Pan Leukocyte Marker) - With BSA and Azide. The antibodies are raised in Mouse and are from clone 156-4H9. This antibody is applicable in IF, FC

Monoclonal CD48 (Pan Leukocyte Marker) Antibody - Without BSA and Azide, Clone: 5-4.8

AMM01591G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD48 (Pan Leukocyte Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone 5-4.8. This antibody is applicable in IF, FC

Monoclonal CD48 (Pan Leukocyte Marker) Antibody - Without BSA and Azide, Clone: 156-4H9

AMM01589G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD48 (Pan Leukocyte Marker) - Without BSA and Azide. The antibodies are raised in Mouse and are from clone 156-4H9. This antibody is applicable in IF, FC

Leukocyte protein

30-1168 5 ml
EUR 601.2
Description: Purified native Human Leukocyte protein

Leukocyte Esterase protein

30-1167 1 mL
EUR 315.6
Description: Purified native Human Leukocyte Esterase protein

Bovine Leukocyte ELISA Kit

QY-E60109 96T
EUR 511.2

CD45 Antibody (Leukocyte marker)

V8044-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8044-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8044SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8395-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8395-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8395SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8396-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8396-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8396SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8397-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8397-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V8397SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2240-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2240-20UG 20 ug
EUR 153.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2240IHC-7ML 7 ml
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2240SAF-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2394-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2394-20UG 20 ug
EUR 153.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2394IHC-7ML 7 ml
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2394SAF-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2399-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2399-20UG 20 ug
EUR 153.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2399IHC-7ML 7 ml
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2399SAF-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2400-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45, B220, LCA and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2400-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45, B220, LCA and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2400IHC-7ML 7 ml
EUR 349.3
Description: CD45R, also designated CD45, B220, LCA and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2400SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45, B220, LCA and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2401-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2401-20UG 20 ug
EUR 153.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2401IHC-7ML 7 ml
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V2401SAF-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3223-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3223-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3223SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3290-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3290-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3290SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3291-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3291-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3291SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3656-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3656-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3656IHC-7ML 7 ml
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3656SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3773-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3773-20UG 20 ug
EUR 153.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3773IHC-7ML 7 ml
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3773SAF-100UG 100 ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3963-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3963-20UG 20 ug
EUR 153.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CD45 Antibody (Leukocyte marker)

V3963SAF-100UG 100 ug
EUR 349.3
Description: CD45, also referred to as CD45R and PTPRC (Protein tyrosine phosphatase receptor type C), has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.

Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alternative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. Clone 2B11 antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Selectin, Leukocyte (SELL) Antibody

20-abx174491
  • EUR 944.40
  • EUR 493.20
  • 1 mg
  • 200 ug

Selectin, Leukocyte (SELL) Antibody

20-abx174492
  • EUR 1011.60
  • EUR 526.80
  • 1 mg
  • 200 ug

Selectin, Leukocyte (SELL) Antibody

20-abx178344
  • EUR 1362.00
  • EUR 661.20
  • 1 mg
  • 200 ug

Selectin, Leukocyte (SELL) Antibody

20-abx178345
  • EUR 1545.60
  • EUR 744.00
  • 1 mg
  • 200 ug

Selectin, Leukocyte (SELL) Antibody

20-abx101920
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Selectin, Leukocyte (SELL) Antibody

20-abx101921
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Selectin, Leukocyte (SELL) Antibody

20-abx129464
  • EUR 360.00
  • EUR 159.60
  • EUR 961.20
  • EUR 510.00
  • EUR 309.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

CD45RA Antibody (Leukocyte marker)

V8043-100UG 100 ug
EUR 349.3
Description: Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V8043-20UG 20 ug
EUR 153.3
Description: Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V8043SAF-100UG 100 ug
EUR 349.3
Description: Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V8403-100UG 100 ug
EUR 349.3
Description: Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V8403-20UG 20 ug
EUR 153.3
Description: Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V8403SAF-100UG 100 ug
EUR 349.3
Description: Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V2238-100UG 100 ug
EUR 349.3
Description: This antibody recognizes a protein of 205kDa-220kDa, identified as CD45RA, an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ Tcells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin Tcells. T-cells expressing CD45RO are memory Tcells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral Tcells. This CD45RA antibody is useful in the study of the subpopulation of CD4+ or CD8+ T-cells. It is especially useful in differentiating T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V2238-20UG 20 ug
EUR 153.3
Description: This antibody recognizes a protein of 205kDa-220kDa, identified as CD45RA, an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ Tcells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin Tcells. T-cells expressing CD45RO are memory Tcells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral Tcells. This CD45RA antibody is useful in the study of the subpopulation of CD4+ or CD8+ T-cells. It is especially useful in differentiating T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V2238IHC-7ML 7 ml
EUR 349.3
Description: This antibody recognizes a protein of 205kDa-220kDa, identified as CD45RA, an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ Tcells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin Tcells. T-cells expressing CD45RO are memory Tcells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral Tcells. This CD45RA antibody is useful in the study of the subpopulation of CD4+ or CD8+ T-cells. It is especially useful in differentiating T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V2238SAF-100UG 100 ug
EUR 349.3
Description: This antibody recognizes a protein of 205kDa-220kDa, identified as CD45RA, an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ Tcells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin Tcells. T-cells expressing CD45RO are memory Tcells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral Tcells. This CD45RA antibody is useful in the study of the subpopulation of CD4+ or CD8+ T-cells. It is especially useful in differentiating T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V2403-100UG 100 ug
EUR 349.3
Description: CD45RA is an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V2403-20UG 20 ug
EUR 153.3
Description: CD45RA is an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).

CD45RA Antibody (Leukocyte marker)

V9397-100UG 100ug
EUR 349.3
Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
The availability of the proposed pipeline will enable environment friendly, correct and reproducible RGC quantification required for assessing the loss of life/survival of RGCs in illness fashions.
Key phrases: Cell segmentation; Fluorescent microscopy; Homomorphic filter; On-line parameter tuning; Retinal ganglion cell (RGC)

 

Liriopesides B induces apoptosis and cell cycle arrest in human non‑small cell lung most cancers cells

 

Dedicator of cytokinesis 2 (DOCK2) is important for the B cell differentiation, BCR signaling and humoral immune response.
Nevertheless, the function of DOCK2 within the reminiscence response of B cell is unknown.
Through the use of two DOCK2 poor sufferers, we discovered that the reminiscence B cells have been decreased and the early activation of DOCK2 poor reminiscence B cells was abolished to the diploma of naïve B cells as a result of decreased expression of CD19 and CD21 mechanistically.
Apparently the expression of LEF-1, a adverse regulator of CD21, was elevated in DOCK2 poor B cells.
This was linked to the elevated expression of HIF-1α and cell metabolism, which in flip affected the ER construction.
Lastly, the discount of reminiscence B cells in DOCK2 sufferers was as a result of elevated apoptosis, which may be associated with the elevated metabolism.
Key phrases: B cell; DOCK2; LEF-1
B cell zone reticular cell microenvironments form CXCL13 gradient formation
By way of the formation of focus gradients, morphogens drive graded responses to extracellular alerts, thereby fine-tuning cell behaviors in advanced tissues.
Right here we present that the chemokine CXCL13 varieties each soluble and immobilized gradients.
Particularly, CXCL13+follicular reticular cells kind a small-world community of steerage constructions, with pc simulations and optimization evaluation predicting that immobilized gradients created by this community promote B cell trafficking.
In step with this prediction, imaging evaluation present that CXCL13 binds to extracellular matrix parts in situ, constraining its diffusion. CXCL13 solubilization requires the protease cathepsin B that cleaves CXCL13 right into a secure product.
Mice missing cathepsin B show aberrant follicular structure, a phenotype related to efficient B cell homing to however not inside lymph nodes.
Our knowledge thus recommend that reticular cells of the B cell zone generate microenvironments that form each immobilized and soluble CXCL13 gradients

 

Mouse Ig fraction

31R-1040 10 mg
EUR 180
Description: Purified Mouse Ig fraction for use as a control or blocking reagent

Sheep Ig fraction

31R-1047 10 mg
EUR 136.8
Description: Purified Sheep Ig fraction for use as a control or blocking reagent

Bovine Ig fraction

31R-1001 10 mg
EUR 136.8
Description: Bovine Ig fraction control or blocking reagent

Rabbit Ig fraction

31R-1018 10 mg
EUR 136.8
Description: Rabbit Ig fraction control or blocking reagent

Bovine Ig fraction

31R-1025 10 mg
EUR 136.8
Description: Purified Bovine Ig fraction for use as a control or blocking reagent

Rabbit Ig fraction

31R-1042 10 mg
EUR 136.8
Description: Purified Rabbit Ig fraction for use as a control or blocking reagent

Chicken Ig fraction

31R-1004 10 mg
EUR 248.4
Description: Chicken Ig fraction control or blocking reagent

Hamster Ig fraction

31R-1009 10 mg
EUR 165.6
Description: Hamster Ig fraction control or blocking reagent

Chicken Ig fraction

31R-1028 10 mg
EUR 248.4
Description: Purified Chicken Ig fraction for use as a control or blocking reagent

Guinea Pig Ig fraction

31R-1007 10 mg
EUR 138
Description: Guinea Pig Ig fraction control or blocking reagent

Guinea Pig Ig fraction

31R-1031 10 mg
EUR 165.6
Description: Purified Guinea Pig Ig fraction for use as a control or blocking reagent

BSA Fraction V (pH 5.2)

AK8245-0100 100g Ask for price

BSA Fraction V (pH 5.2)

AK8245-0500 500g Ask for price

BSA Fraction V (pH 5.2)

AK8245-1000 1kg Ask for price

BSA Fraction V (pH 7.0)

AK8905-0100 100g Ask for price

BSA Fraction V (pH 7.0)

AK8905-0500 500g Ask for price

BSA Fraction V (pH 7.0)

AK8905-1000 1kg Ask for price

AFP antibody (Ig fraction)

70R-14345 1 ml
EUR 166.8
Description: Goat polyclonal AFP antibody (Ig fraction)

Albumin, Cohn fraction pH5.2

AR2440 50g
EUR 180.06

FITC antibody (IgG fraction)

20C-CR1056SP 1 ml
EUR 289.2
Description: Rabbit polyclonal FITC antibody

Fraction Column Dufton 150mm

QFC112 EACH
EUR 140.4

Fraction Column Dufton 300mm

QFC122 EACH
EUR 157.2

WSE-7422 EzSubcell Fraction

2332338 1unit
EUR 477.6
Description: Fr act i onat i on of N ucl ei & M i t ochondr i a

Fraction V BSA 10% solution

30R-AB022 2x10ml
EUR 232.8
Description: Bovine Serum Albumin, Crohn Fraction V 10% solution

Fibrinogen antibody (IgG fraction)

20R-1420 1 liter Ask for price
Description: Goat polyclonal Human Fibrinogen antibody (IgG fraction)

Fraction V BSA powder, pH 7

BAC62-0050 50gm
EUR 407.16

Fraction V BSA powder, pH 7

BAC62-0100 100gm
EUR 489.84

Fraction V BSA powder, pH 7

BAC62-0500 500gm
EUR 702

Fraction V BSA powder, pH 7

BAC62-1000 1KG
EUR 1014

Fraction V BSA powder, pH 7

BAC62-10000 10KG Ask for price

Fraction V BSA powder, pH 5.2

BAC63-0050 50gm
EUR 407.16

Fraction V BSA powder, pH 5.2

BAC63-0100 100gm
EUR 489.84

Fraction V BSA powder, pH 5.2

BAC63-0500 500gm
EUR 702

Fraction V BSA powder, pH 5.2

BAC63-1000 1KG
EUR 1014

Fraction V BSA powder, pH 5.2

BAC63-10000 10KG Ask for price

Rat Brain Lysate Membrane Fraction

IRTBRTLM100UG each
EUR 870
Description: Rat Brain Lysate Membrane Fraction

Human Skin Lysate Membrane Fraction

IHUSKNTLM100UG each
EUR 870
Description: Human Skin Lysate Membrane Fraction

Human Lung Lysate Membrane Fraction

IHULGTLM100UG each
EUR 914
Description: Human Lung Lysate Membrane Fraction

Human Albumin antibody (IgG fraction)

20-1001 1 L Ask for price
Description: Goat polyclonal Human Albumin antibody

Mouse Brain Lysate Membrane Fraction

IMSBRTLM100UG each
EUR 870
Description: Mouse Brain Lysate Membrane Fraction

Human Heart Lysate Membrane Fraction

IHUHTTLM100UG each
EUR 870
Description: Human Heart Lysate Membrane Fraction

Human Ileum Lysate Membrane Fraction

IHUILMTLM100UG each
EUR 870
Description: Human Ileum Lysate Membrane Fraction

Human Ovary Lysate Membrane Fraction

IHUOVTLM100UG each
EUR 1610
Description: Human Ovary Lysate Membrane Fraction

Human Colon Lysate Membrane Fraction

IHUCLNTLM100UG each
EUR 1246
Description: Human Colon Lysate Membrane Fraction

Human Liver Lysate Membrane Fraction

IHULRTLM100UG each
EUR 870
Description: Human Liver Lysate Membrane Fraction

Hexane fraction, GlenDry™, anhydrous

GS2256-1 1
EUR 76.4

Hexane fraction, GlenDry™, anhydrous

GS2256-100 100
EUR 53.2

Hexane fraction, GlenDry™, anhydrous

GS2256-2500 2500
EUR 136.5

Hexane fraction, GlenDry™, anhydrous

GS2256-500 500
EUR 62.4

Human Brain Lysate Membrane Fraction

IHUBRTLM100UG each
EUR 870
Description: Human Brain Lysate Membrane Fraction

Pyruvate Kinase antibody (IgG fraction)

20R-PG010 1 ml
EUR 282
Description: Goat polyclonal Pyruvate Kinase antibody (IgG fraction)

Pyruvate Kinase antibody (IgG fraction)

20C-CR7017GP 1 mL
EUR 282
Description: Goat polyclonal Pyruvate Kinase antibody (IgG fraction)

Human Testis Lysate Membrane Fraction

IHUTSTTLM100UG each
EUR 870
Description: Human Testis Lysate Membrane Fraction

Human Thymus Lysate Membrane Fraction

IHUTYMTLM100UG each
EUR 1610
Description: Human Thymus Lysate Membrane Fraction

Human Uterus Lysate Membrane Fraction

IHUUTETLM100UG each
EUR 870
Description: Human Uterus Lysate Membrane Fraction

Human Tonsil Lysate Membrane Fraction

IHUTONTLM100UG each
EUR 1413
Description: Human Tonsil Lysate Membrane Fraction

Human Spleen Lysate Membrane Fraction

IHUSPTLM100UG each
EUR 870
Description: Human Spleen Lysate Membrane Fraction

Human Kidney Lysate Membrane Fraction

IHUKDTLM100UG each
EUR 870
Description: Human Kidney Lysate Membrane Fraction

Human Rectum Lysate Membrane Fraction

IHURCTTLM100UG each
EUR 870
Description: Human Rectum Lysate Membrane Fraction

Heptane fraction, GlenDry™, anhydrous

GS8770-1 1
EUR 76.5

Heptane fraction, GlenDry™, anhydrous

GS8770-100 100
EUR 53.2

Heptane fraction, GlenDry™, anhydrous

GS8770-2500 2500
EUR 137.4

Heptane fraction, GlenDry™, anhydrous

GS8770-500 500
EUR 63

Human Artery Lysate Membrane Fraction

IHUARTLM100UG each
EUR 1413
Description: Human Artery Lysate Membrane Fraction

Human Breast Lysate Membrane Fraction

IHUBTTLM100UG each
EUR 870
Description: Human Breast Lysate Membrane Fraction

Human Vaginal Lysate Membrane Fraction

IHUVAGTLM100UG each
EUR 870
Description: Human Vaginal Lysate Membrane Fraction

Human Adipose Lysate Membrane Fraction

IHUADPTTLM100UG each
EUR 1413
Description: Human Adipose Lysate Membrane Fraction

Human Thyroid Lysate Membrane Fraction

IHUTRTLM100UG each
EUR 870
Description: Human Thyroid Lysate Membrane Fraction

Human Skin Lysate Cytoplasmic Fraction

IHUSKNTLCYT100UG each
EUR 393
Description: Human Skin Lysate Cytoplasmic Fraction

Human Stomach Lysate Membrane Fraction

IHUSTTLM100UG each
EUR 870
Description: Human Stomach Lysate Membrane Fraction

Human Trachea Lysate Membrane Fraction

IHUTCATLM100UG each
EUR 870
Description: Human Trachea Lysate Membrane Fraction

Human Jejunum Lysate Membrane Fraction

IHUJEJTLM100UG each
EUR 870
Description: Human Jejunum Lysate Membrane Fraction