Tag: panel truck

December 10, 2020

Combined p14ARF and Interferon-β Gene Transfer to the Human Melanoma Cell Line SK-MEL-147 Promotes Oncolysis and Immune Activation

Immune evasion is a vital most cancers hallmark and the understanding of its mechanisms has generated profitable therapeutic approaches. Induction of immunogenic cell demise (ICD) is anticipated to draw immune cell populations that promote innate and adaptive immune responses. Right here, we current a important advance for our adenovirus-mediated gene remedy method, the place the mixed p14ARF and human interferon-β (IFNβ) gene switch to human […]

July 27, 2020

Investigate co-purifying Host Cell Proteins Presence

  Enhancing the Analytical toolbox to analyze co-purifying Host Cell Proteins presence: N-(4)-(β-acetylglucosaminyl)-L-asparaginase case research     Ranges of host cell proteins (HCP) in purification intermediates and drug substances (DS) of monoclonal antibodies (mAb) should be rigorously monitored for the manufacturing of secure and efficacious biotherapeutics. In the course of the improvement of mAb1, an IgG1 product, sudden outcomes generated with HCP ELISA equipment triggered an investigation […]