Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis
Autoreactive B cells mediate autoimmune pathology, however precisely how stays unknown. A trademark of rheumatoid arthritis (RA), a standard autoimmune illness, is the presence of disease-specific anticitrullinated protein antibodies (ACPAs). Right here, we confirmed that ACPA-positive B cells in sufferers with RA strongly expressed T cell-stimulating ligands, produced considerable proinflammatory cytokines, and have been proliferative whereas escaping inhibitory alerts.
This activated state was discovered at totally different levels in numerous levels of illness: highest in sufferers with recent-onset RA, reasonable in sufferers with established RA, and much much less pronounced in ACPA-positive people “in danger” for growing illness. The activated autoreactive B cell response persevered in sufferers who achieved medical remission with standard remedy. ACPA-positive B cells in blood and synovial fluid secreted elevated quantities of the chemoattractant interleukin-8, which attracted neutrophils, probably the most considerable immune cell in arthritic joints.
Tetanus toxoid-specific B cells from the identical sufferers exhibited properties of reminiscence B cells with out the activation and proliferation phenotype, however these cells transiently acquired an analogous proliferative phenotype upon booster vaccination. Collectively, these knowledge indicated that steady antigenic triggering of autoreactive B cells happens in human autoimmune illness and assist the rising idea of immunological exercise that persists beneath remedy even in medical remission, which can revise our present idea of remedy targets for future therapeutic interventions. As well as, our knowledge pointed to a pathogenic position of ACPA-positive B cells within the inflammatory illness course of underlying RA and favor approaches that intention at their antigen-specific inactivation or depletion.
Destiny Mapping Quantifies the Dynamics of B Cell Growth and Activation all through Life
Zika Virus NS2A and NS4A Downregulate the Promoter Exercise of Nuclear Issue Kappa-Gentle-Chain-Enhancer of Activated B Cells
Receptor Activator Of Nuclear Factor Kappa B (RANk) Antibody |
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20-abx174339 | Abbexa |
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Receptor Activator Of Nuclear Factor Kappa B (RANk) Antibody |
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20-abx174340 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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20-abx128602 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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20-abx104350 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx270227-1ml | Abbexa | 1 ml | EUR 450 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx270227-200l | Abbexa | 200 µl | EUR 325 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx128602-100l | Abbexa | 100 µl | EUR 275 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx128602-1ml | Abbexa | 1 ml | EUR 750 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx128602-200l | Abbexa | 200 µl | EUR 337.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx130205-100l | Abbexa | 100 µl | EUR 287.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx130205-1ml | Abbexa | 1 ml | EUR 812.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx130205-200l | Abbexa | 200 µl | EUR 362.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx104350-100g | Abbexa | 100 µg | EUR 775 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx104350-20g | Abbexa | 20 µg | EUR 275 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx104350-50g | Abbexa | 50 µg | EUR 350 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx131781-100g | Abbexa | 100 µg | EUR 787.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx131781-20g | Abbexa | 20 µg | EUR 350 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody |
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abx131781-5g | Abbexa | 5 µg | EUR 275 |
Receptor Activator Of Nuclear Factor Kappa B (RANk) Antibody |
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abx174339-100l | Abbexa | 100 µl | EUR 275 |
Receptor Activator Of Nuclear Factor Kappa B (RANk) Antibody |
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abx174339-1ml | Abbexa | 1 ml | EUR 787.5 |
Receptor Activator Of Nuclear Factor Kappa B (RANk) Antibody |
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abx174339-200l | Abbexa | 200 µl | EUR 350 |
Receptor Activator Of Nuclear Factor Kappa B (RANk) Antibody |
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abx174340-100l | Abbexa | 100 µl | EUR 850 |
Receptor Activator Of Nuclear Factor Kappa B (RANk) Antibody |
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abx174340-1ml | Abbexa | 1 ml | Ask for price |
Receptor Activator Of Nuclear Factor Kappa B (RANk) Antibody |
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abx174340-200l | Abbexa | 200 µl | Ask for price |
Active Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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APC057Hu01 | Cloud-Clone | 10ug | EUR 302 |
Active Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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4-APC057Hu01 | Cloud-Clone |
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Description: Recombinant Human Receptor Activator Of Nuclear Factor Kappa B expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
Active Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU55749-100ug | Biomatik Corporation | 100ug | EUR 936.1 |
Active Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU55749-1mg | Biomatik Corporation | 1mg | EUR 4716.4 |
Active Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU55749-50ug | Biomatik Corporation | 50ug | EUR 725.8 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (PE) |
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20-abx270879 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (PE) |
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20-abx270989 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (PE) |
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abx270879-1ml | Abbexa | 1 ml | EUR 737.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (PE) |
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abx270879-200l | Abbexa | 200 µl | EUR 612.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (PE) |
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abx270989-1ml | Abbexa | 1 ml | EUR 1212.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (PE) |
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abx270989-200l | Abbexa | 200 µl | EUR 737.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (APC) |
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20-abx270647 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (APC) |
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20-abx270757 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (APC) |
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abx270647-1ml | Abbexa | 1 ml | EUR 875 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (APC) |
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abx270647-200l | Abbexa | 200 µl | EUR 725 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (APC) |
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abx270757-1ml | Abbexa | 1 ml | EUR 1437.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (APC) |
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abx270757-200l | Abbexa | 200 µl | EUR 875 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU52109-100ug | Biomatik Corporation | 100ug | EUR 517 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU52109-1mg | Biomatik Corporation | 1mg | EUR 2293.2 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU52109-50ug | Biomatik Corporation | 50ug | EUR 415.8 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU53947-100ug | Biomatik Corporation | 100ug | EUR 566.5 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU53947-1mg | Biomatik Corporation | 1mg | EUR 2511.6 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU53947-50ug | Biomatik Corporation | 50ug | EUR 455.4 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU43561-100ug | Biomatik Corporation | 100ug | EUR 542.3 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU43561-1mg | Biomatik Corporation | 1mg | EUR 2402.4 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPU43561-50ug | Biomatik Corporation | 50ug | EUR 435.6 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPC057Hu01 | Cloud-Clone | 10ug | EUR 168 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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4-RPC057Hu01 | Cloud-Clone |
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Description: Recombinant Human Receptor Activator Of Nuclear Factor Kappa B expressed in: E.coli |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPC057Mu01 | Cloud-Clone | 10ug | EUR 176 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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4-RPC057Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Receptor Activator Of Nuclear Factor Kappa B expressed in: E.coli |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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RPC057Ra01 | Cloud-Clone | 10ug | EUR 184 |
Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) |
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4-RPC057Ra01 | Cloud-Clone |
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Description: Recombinant Rat Receptor Activator Of Nuclear Factor Kappa B expressed in: E.coli |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (FITC) |
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20-abx270415 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (FITC) |
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20-abx270525 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (FITC) |
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abx270415-1ml | Abbexa | 1 ml | EUR 612.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (FITC) |
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abx270415-200l | Abbexa | 200 µl | EUR 512.5 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (FITC) |
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abx270525-1ml | Abbexa | 1 ml | EUR 1000 |
Receptor Activator of Nuclear Factor Kappa B (RANk) Antibody (FITC) |
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abx270525-200l | Abbexa | 200 µl | EUR 612.5 |
Rat Receptor Activator Of Nuclear Factor Kappa B ELISA Kit |
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IRTRANKKT | Innovative research | each | EUR 790 |
Description: Rat Receptor Activator Of Nuclear Factor Kappa B ELISA Kit |
Mouse receptor activator of nuclear factor kappa B ELISA Kit |
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ELA-E2057m | Lifescience Market | 96 Tests | EUR 1038 |
Human Receptor Activator Of Nuclear Factor Kappa B ELISA Kit |
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IHURANKKT | Innovative research | each | EUR 733 |
Description: Human Receptor Activator Of Nuclear Factor Kappa B ELISA Kit |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx270109 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx270204 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx270211 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx270212 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx129539 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx130179 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx131777 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx131778 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx131779 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx131780 | Abbexa |
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Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx174341 | Abbexa |
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Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx178216 | Abbexa |
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Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx178217 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) Antibody |
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abx237108-100ug | Abbexa | 100 ug | EUR 661.2 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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20-abx104600 | Abbexa |
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Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) Antibody |
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abx237108-100g | Abbexa | 100 µg | EUR 350 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx270109-1ml | Abbexa | 1 ml | EUR 425 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx270109-200l | Abbexa | 200 µl | EUR 300 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx270204-1ml | Abbexa | 1 ml | EUR 425 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx270204-200l | Abbexa | 200 µl | EUR 300 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx270211-1ml | Abbexa | 1 ml | EUR 425 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx270211-200l | Abbexa | 200 µl | EUR 300 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx270212-1ml | Abbexa | 1 ml | EUR 425 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx270212-200l | Abbexa | 200 µl | EUR 300 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx129539-100l | Abbexa | 100 µl | EUR 262.5 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx129539-1ml | Abbexa | 1 ml | EUR 687.5 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx129539-200l | Abbexa | 200 µl | EUR 325 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx130179-100l | Abbexa | 100 µl | EUR 262.5 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx130179-1ml | Abbexa | 1 ml | EUR 725 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx130179-200l | Abbexa | 200 µl | EUR 337.5 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx104600-100g | Abbexa | 100 µg | EUR 675 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx104600-20g | Abbexa | 20 µg | EUR 250 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx104600-50g | Abbexa | 50 µg | EUR 312.5 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131777-100g | Abbexa | 100 µg | EUR 712.5 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131777-20g | Abbexa | 20 µg | EUR 325 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131777-5g | Abbexa | 5 µg | EUR 262.5 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131778-100g | Abbexa | 100 µg | EUR 775 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131778-20g | Abbexa | 20 µg | EUR 350 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131778-5g | Abbexa | 5 µg | EUR 275 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131779-100g | Abbexa | 100 µg | EUR 775 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131779-20g | Abbexa | 20 µg | EUR 350 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131779-5g | Abbexa | 5 µg | EUR 275 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131780-100g | Abbexa | 100 µg | EUR 775 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131780-20g | Abbexa | 20 µg | EUR 350 |
Receptor Activator of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx131780-5g | Abbexa | 5 µg | EUR 275 |
Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx174341-100l | Abbexa | 100 µl | EUR 262.5 |
Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx174341-1ml | Abbexa | 1 ml | EUR 712.5 |
Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Antibody |
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abx174341-200l | Abbexa | 200 µl | EUR 325 |
Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) Protein |
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20-abx168512 | Abbexa |
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Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) Protein |
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abx168512-1ml | Abbexa | 1 ml | EUR 225 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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APA855Mu01 | Cloud-Clone | 10ug | EUR 310 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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4-APA855Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Receptor Activator Of Nuclear Factor Kappa B Ligand expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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APA855Mu61 | Cloud-Clone | 10ug | EUR 320 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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4-APA855Mu61 | Cloud-Clone |
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Description: Recombinant Mouse Receptor Activator Of Nuclear Factor Kappa B Ligand expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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APA855Ra61 | Cloud-Clone | 10ug | EUR 211 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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4-APA855Ra61 | Cloud-Clone |
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Description: Recombinant Rat Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55615-100ug | Biomatik Corporation | 100ug | EUR 953.7 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55615-1mg | Biomatik Corporation | 1mg | EUR 4829.5 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55615-50ug | Biomatik Corporation | 50ug | EUR 743.1 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55616-100ug | Biomatik Corporation | 100ug | EUR 1267.2 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55616-1mg | Biomatik Corporation | 1mg | EUR 4992 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55616-50ug | Biomatik Corporation | 50ug | EUR 768 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55617-100ug | Biomatik Corporation | 100ug | EUR 651.2 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55617-1mg | Biomatik Corporation | 1mg | EUR 3294.2 |
Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) |
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RPU55617-50ug | Biomatik Corporation | 50ug | EUR 506.9 |
Receptor Activator Of Nuclear Factor Kappa B (RANk) Monoclonal Antibody |
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CAU30364-100ul | Biomatik Corporation | 100ul | EUR 248.6 |
Receptor Activator Of Nuclear Factor Kappa B (RANk) Monoclonal Antibody |
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CAU30364-200ul | Biomatik Corporation | 200ul | EUR 310.8 |