Introduction and targets: The activation of hepatic stellate cells (HSCs) is the primary reason for liver fibrosis. The useful results of fibroblast development issue (FGF) 19 on liver fibrosis had been not too long ago reported. The S. miltiorrhiza in addition to S. miltiorrhiza derived bioactive chemical parts has proven distinguished antifibrotic results in liver fibrosis however the mechanism continues to be not totally understood. We aimed to research the bioactive compounds derived from S. miltiorrhiza which exerts antifibrotic results in HSCs through regulating FGF19.
Supplies and strategies: FGF19 stage in tradition media was decided by enzyme-linked immunosorbent assay. Cell proliferation was measured by Cell Counting Package-Eight assay. Additional, mRNA and protein expressions had been assessed by quantitative polymerase chain response and western blotting, respectively. Pulling down of FGF receptor 4 (FGFR4) by transfection with siRNA was used to substantiate the function of FGF19/FGFR4 signaling.
Outcomes: Utilizing the human HSC cell line LX-2, we screened a number of pure merchandise and located that bioactive compounds remoted from Salvia miltiorrhiza, notably salvianolic acid B, strongly upregulated FGF19 secretion by LX-2 cells. We additional confirmed that salvianolic acid B inhibited lipopolysaccharide (LPS)-induced HSC proliferation and activation. LPS remedy might also cut back the mRNA and protein ranges of FGF19 and its receptor FGFR4. Salvianolic acid B remedy restored the impaired expressions of FGF19 and FGFR4. Lastly, FGFR4 knockdown abolished the antifibrotic results of salvianolic acid B within the LPS-induced HSC activation mannequin.
Conclusions: Salvianolic acid B prevented LPS-induced HSC proliferation and activation by enhancing antifibrotic FGF19/FGFR4 signaling.
Glutaredoxin deficiency promotes activation of the reworking development issue beta pathway in airway epithelial cells, in affiliation with fibrotic airway transforming
S-glutathionylation of reactive protein cysteines is a post-translational occasion that performs a important function in transducing indicators from oxidants into organic responses. S-glutathionylation might be reversed by the deglutathionylating enzyme glutaredoxin (GLRX). Now we have beforehand demonstrated that ablation of Glrx sensitizes mice to the event of parenchymal lung fibrosis(1). It stays unclear whether or not GLRX additionally controls airway fibrosis, a scientific function related to bronchial asthma and continual obstructive pulmonary illness, and whether or not GLRX controls the biology of airway epithelial cells, which have been implicated within the pathophysiology of those ailments.
Within the current examine we utilized a home mud mite (HDM) mannequin of allergic airway illness in wild sort (WT) and Glrx-/- mice on a C57BL/6 background susceptible to develop airway fibrosis, and tracheal basal stem cells derived from WT mice, international Glrx-/- mice, or bi-transgenic mice permitting conditional ablation of the Glrx gene. Herein we present that absence of Glrx led to enhanced HDM-induced collagen deposition, elevated ranges of reworking development issue beta 1 (TGFB1) within the bronchoalveolar lavage, and resulted in will increase in airway hyperresponsiveness. Airway epithelial cells remoted from Glrx-/- mice or following conditional ablation of Glrx confirmed spontaneous will increase in secretion of TGFB1. Glrx-/- basal cells additionally confirmed spontaneous TGFB pathway activation, in affiliation with elevated expression of mesenchymal genes, together with collagen 1a1 and fibronectin. Total, these findings counsel that GLRX regulates airway fibrosis through a mechanism(s) that contain the plasticity of basal cells, the stem cells of the airways.
The outbreak of the 2019 coronavirus illness (named, COVID‑19), brought on by the novel SARS‑CoV‑2 virus, represents a worldwide extreme risk to public well being. It’s of the utmost significance to characterize the immune responses towards the SARS‑CoV‑2 and the mechanisms of hyperinflammation, to be able to design higher therapeutic methods for COVID‑19. Within the current examine, a transcriptomic evaluation was carried out to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID‑19 sufferers and controls. Our information concordantly revealed elevated humoral responses to an infection. The elucidation of the host responses to SARS‑CoV‑2 an infection could additional enhance our understanding of COVID‑19 pathogenesis and counsel higher therapeutic methods.
Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling
Analysis of B–cell intracellular signaling by monitoring the PI3K-Akt axis in sufferers with frequent variable immunodeficiency and activated phosphoinositide 3-kinase delta syndrome
Background: Major antibody deficiencies (PADs) are characterised by hypogammaglobulinemia and impaired B-cell differentiation. Sufferers with frequent variable immunodeficiency (CVID) current extreme reductions in not less than 2 serum immunoglobulins and impaired terminal differentiation of B cells. Most sufferers with CVID don’t seem to current monogenic defects. Activated phosphoinositide 3-kinase delta syndrome (APDS), brought on by gain-of-function mutations within the PIK3CD gene (p110δ), can current in sufferers with a CVID-like phenotype. Reminiscence B-cell differentiation requires the orchestrated activation of quite a few intracellular signaling pathways, which promote transcriptional packages required for long-term B-cell survival. The goal of this examine was to develop a circulation cytometry assay to hint the PI3K-Akt-mTOR pathway, a important part of B-cell homeostasis, and analyze its standing in PADs.
Strategies: We analyzed the intracellular expression of Akt and S6 by circulation cytometry and their phosphorylation standing in each baseline circumstances and upon B-cell receptor activation with anti-IgM in numerous main B-cell subsets of sufferers with CVID and APDS.
Outcomes: B cells from CVID sufferers confirmed decreased phosphorylation in Akt and S6 proteins after anti-IgM stimulation. Constitutive excessive baseline B-cell ranges of Akt and S6 phosphorylation in a affected person with APDS had been decreased as soon as m-TOR inhibition remedy was initiated.
 Antibody) Immunoglobulin Kappa (Igk) Antibody |
|
20-abx176921 |
Abbexa |
|
|
|
|
Immunoglobulin Kappa (Igk) Antibody |
|
20-abx176922 |
Abbexa |
|
|
|
|
 Antibody (PE)) Immunoglobulin Kappa (Igk) Antibody (PE) |
|
20-abx274585 |
Abbexa |
-
EUR 594.00
-
EUR 309.60
-
EUR 1746.00
-
EUR 811.20
-
EUR 477.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Antibody (APC)) Immunoglobulin Kappa (Igk) Antibody (APC) |
|
20-abx274586 |
Abbexa |
-
EUR 678.00
-
EUR 326.40
-
EUR 2131.20
-
EUR 978.00
-
EUR 543.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
) OVA Conjugated Immunoglobulin Kappa (Igk) |
|
4-CPD038Hu21 |
Cloud-Clone |
-
EUR 492.02
-
EUR 254.40
-
EUR 1515.07
-
EUR 585.02
-
EUR 1050.05
-
EUR 404.40
-
EUR 3607.68
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
|
Description: Recombinant Human Immunoglobulin Kappa expressed in: Protein conjugation |
OVA Conjugated Immunoglobulin Kappa (Igk) |
|
4-CPD038Mu21 |
Cloud-Clone |
-
EUR 550.08
-
EUR 271.20
-
EUR 1732.80
-
EUR 657.60
-
EUR 1195.20
-
EUR 444.00
-
EUR 4152.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
|
|
Description: Recombinant Mouse Immunoglobulin Kappa expressed in: chemical synthesis |
 Protein) Human Immunoglobulin G1 Kappa (IgG1 Kappa) Protein |
|
abx670165-1mg |
Abbexa |
1 mg |
EUR 560.4 |
|
|
 Protein) Human Immunoglobulin G2 Kappa (IgG2 Kappa) Protein |
|
abx670166-1mg |
Abbexa |
1 mg |
EUR 627.6 |
|
|
 Protein) Mouse Immunoglobulin G1 Kappa (IgG1 Kappa) Protein |
|
abx670291-1mg |
Abbexa |
1 mg |
EUR 760.8 |
|
|
 Protein) Mouse Immunoglobulin G2a Kappa (IgG2a Kappa) Protein |
|
abx670292-1mg |
Abbexa |
1 mg |
EUR 760.8 |
|
|
 Protein) Mouse Immunoglobulin G2b Kappa (IgG2b Kappa) Protein |
|
abx670293-1mg |
Abbexa |
1 mg |
EUR 760.8 |
|
|
 Protein) Mouse Immunoglobulin M Kappa (IgM Kappa) Protein |
|
abx670294-1mg |
Abbexa |
1 mg |
EUR 760.8 |
|
|
 Protein) Mouse Immunoglobulin E Kappa (IgE Kappa) Protein |
|
abx670299-05mg |
Abbexa |
0.5 mg |
EUR 727.2 |
|
|
 Rabbit Polyclonal antibody Anti-CRBN |
|
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 418.8 |
 Antibody (APC/Cy7)) Immunoglobulin Kappa (Igk) Antibody (APC/Cy7) |
|
20-abx274584 |
Abbexa |
-
EUR 1161.60
-
EUR 493.20
-
EUR 4051.20
-
EUR 1746.00
-
EUR 878.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Protein (OVA)) Human Immunoglobulin Kappa (Igk) Protein (OVA) |
|
20-abx651861 |
Abbexa |
-
EUR 693.60
-
EUR 309.60
-
EUR 2047.20
-
EUR 811.20
-
EUR 510.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Antibody (FITC)) Immunoglobulin Kappa (Igk) Antibody (FITC) |
|
20-abx270388 |
Abbexa |
-
EUR 678.00
-
EUR 794.40
-
EUR 376.80
-
EUR 1228.80
-
EUR 493.20
|
- 100 tests
- 200 tests
- 25 tests
- 500 tests
- 50 tests
|
|
|
Immunoglobulin Kappa (Igk) Antibody (APC) |
|
20-abx270620 |
Abbexa |
-
EUR 910.80
-
EUR 1078.80
-
EUR 460.80
-
EUR 1746.00
-
EUR 644.40
|
- 100 tests
- 200 tests
- 25 tests
- 500 tests
- 50 tests
|
|
|
Immunoglobulin Kappa (Igk) Antibody (PE) |
|
20-abx270852 |
Abbexa |
-
EUR 794.40
-
EUR 927.60
-
EUR 427.20
-
EUR 1479.60
-
EUR 560.40
|
- 100 tests
- 200 tests
- 25 tests
- 500 tests
- 50 tests
|
|
|
 Antibody Pair) Immunoglobulin Kappa (Igk) Antibody Pair |
|
20-abx370695 |
Abbexa |
|
- 10 × 96 tests
- 5 × 96 tests
|
|
|
 Antibody) Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Antibody |
|
abx122950-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
|
Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Antibody |
|
abx237195-100ug |
Abbexa |
100 ug |
EUR 610.8 |
|
|
Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Antibody |
|
abx237196-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
|
 Antibody) Recombination Signal Binding Protein For Immunoglobulin Kappa J Region Like (RBPJL) Antibody |
|
abx237197-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
|
 Antibody) Mouse Immunoglobulin M Kappa (IgM) Antibody |
|
20511-05011 |
AssayPro |
150 ug |
EUR 260.4 |
 ELISA Kit) Human Immunoglobulin Kappa (Igk) ELISA Kit |
|
20-abx156942 |
Abbexa |
-
EUR 8853.60
-
EUR 4719.60
-
EUR 1093.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
 CLIA Kit) Mouse Immunoglobulin Kappa (Igk) CLIA Kit |
|
20-abx496452 |
Abbexa |
-
EUR 9567.60
-
EUR 5095.20
-
EUR 1177.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
 CLIA Kit) Human Immunoglobulin Kappa (Igk) CLIA Kit |
|
20-abx494060 |
Abbexa |
-
EUR 9567.60
-
EUR 5095.20
-
EUR 1177.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
 ELISA Kit) Mouse Immunoglobulin Kappa (Igk) ELISA Kit |
|
20-abx258908 |
Abbexa |
-
EUR 8853.60
-
EUR 4719.60
-
EUR 1093.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
 Polyclonal Antibody (Mouse)) Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse) |
|
4-PAD038Mu08 |
Cloud-Clone |
-
EUR 301.20
-
EUR 3091.20
-
EUR 768.00
-
EUR 379.20
-
EUR 258.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk) |
Human Immunoglobulin Kappa (Igk) ELISA Kit |
|
SED038Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5677.8 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immunoglobulin Kappa (Igk) in serum, plasma and other biological fluids. |
Human Immunoglobulin Kappa (Igk) ELISA Kit |
|
SED038Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 572.76 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immunoglobulin Kappa (Igk) in serum, plasma and other biological fluids. |
Human Immunoglobulin Kappa (Igk) ELISA Kit |
|
SED038Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 766.8 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immunoglobulin Kappa (Igk) in serum, plasma and other biological fluids. |
Human Immunoglobulin Kappa (Igk) ELISA Kit |
|
SED038Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3090.6 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immunoglobulin Kappa (Igk) in serum, plasma and other biological fluids. |
Human Immunoglobulin Kappa (Igk) ELISA Kit |
|
4-SED038Hu |
Cloud-Clone |
-
EUR 5738.40
-
EUR 3031.20
-
EUR 768.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Immunoglobulin Kappa (Igk) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
Mouse Immunoglobulin Kappa (Igk) ELISA Kit |
|
SED038Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5834.88 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immunoglobulin Kappa (Igk) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Immunoglobulin Kappa (Igk) ELISA Kit |
|
SED038Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 585.7 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immunoglobulin Kappa (Igk) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Immunoglobulin Kappa (Igk) ELISA Kit |
|
SED038Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 785.28 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immunoglobulin Kappa (Igk) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Immunoglobulin Kappa (Igk) ELISA Kit |
|
SED038Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3173.76 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immunoglobulin Kappa (Igk) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Immunoglobulin Kappa (Igk) ELISA Kit |
|
4-SED038Mu |
Cloud-Clone |
-
EUR 5895.60
-
EUR 3114.00
-
EUR 786.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Immunoglobulin Kappa (Igk) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
 Anti-Kappa Light Chain Antibody Clone SPM508, Unconjugated-100ug |
|
3514-MSM1X-P1 |
EnQuireBio |
100ug |
EUR 513.6 |
 Anti-Kappa Light Chain Antibody Clone HP6053, Unconjugated-100ug |
|
3514-MSM4-P1 |
EnQuireBio |
100ug |
EUR 513.6 |
 Anti-Kappa Light Chain Antibody Clone KLC709, Unconjugated-100ug |
|
3514-MSM6-P1 |
EnQuireBio |
100ug |
EUR 513.6 |
 Anti-Kappa Light Chain Antibody Clone KLC1278, Unconjugated-100ug |
|
3514-MSM8-P1 |
EnQuireBio |
100ug |
EUR 513.6 |
 Recombinant Human Glutathione S-transferase kappa 1 Protein, GST, E.coli-100ug |
|
QP6125-ec-100ug |
EnQuireBio |
100ug |
EUR 511.2 |
 Recombinant Human Immunoglobulin iota chain Protein, His-SUMO, E.coli-100ug |
|
QP6882-ec-100ug |
EnQuireBio |
100ug |
EUR 489.6 |
 Goat Kappa immunoglobulin light chain ELISA kit |
|
E06K0067-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Goat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Kappa immunoglobulin light chain ELISA kit |
|
E06K0067-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Goat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Kappa immunoglobulin light chain ELISA kit |
|
E06K0067-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Goat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Rabbit Kappa immunoglobulin light chain ELISA kit |
|
E04K0067-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rabbit Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Kappa immunoglobulin light chain ELISA kit |
|
E04K0067-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rabbit Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Kappa immunoglobulin light chain ELISA kit |
|
E04K0067-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rabbit Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Human Kappa immunoglobulin light chain ELISA kit |
|
E01K0067-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Human Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Kappa immunoglobulin light chain ELISA kit |
|
E01K0067-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Human Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Kappa immunoglobulin light chain ELISA kit |
|
E01K0067-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Human Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Mouse Kappa immunoglobulin light chain ELISA kit |
|
E03K0067-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Kappa immunoglobulin light chain ELISA kit |
|
E03K0067-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Kappa immunoglobulin light chain ELISA kit |
|
E03K0067-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Mouse Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
) ELISA kit for Mouse Igk (Immunoglobulin Kappa) |
|
ELK7759 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
|
|
Description: A sandwich ELISA kit for detection of Immunoglobulin Kappa from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
) ELISA kit for Human Igk (Immunoglobulin Kappa) |
|
ELK5262 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
|
|
Description: A sandwich ELISA kit for detection of Immunoglobulin Kappa from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
 Monkey Kappa immunoglobulin light chain ELISA kit |
|
E09K0067-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Kappa immunoglobulin light chain ELISA kit |
|
E09K0067-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Kappa immunoglobulin light chain ELISA kit |
|
E09K0067-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Monkey Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Rat Kappa immunoglobulin light chain ELISA kit |
|
E02K0067-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Kappa immunoglobulin light chain ELISA kit |
|
E02K0067-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Kappa immunoglobulin light chain ELISA kit |
|
E02K0067-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Dog Kappa immunoglobulin light chain ELISA kit |
|
E08K0067-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Canine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Kappa immunoglobulin light chain ELISA kit |
|
E08K0067-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Canine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Kappa immunoglobulin light chain ELISA kit |
|
E08K0067-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Canine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Pig Kappa immunoglobulin light chain ELISA kit |
|
E07K0067-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Porcine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Kappa immunoglobulin light chain ELISA kit |
|
E07K0067-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Porcine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Kappa immunoglobulin light chain ELISA kit |
|
E07K0067-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Porcine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Human kappa immunoglobulin light chain ELISA Kit |
|
ELA-E0644h |
Lifescience Market |
96 Tests |
EUR 988.8 |
 Polyclonal Antibody (Mouse), APC) Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), APC |
|
4-PAD038Mu08-APC |
Cloud-Clone |
-
EUR 421.20
-
EUR 4038.00
-
EUR 1122.00
-
EUR 538.80
-
EUR 266.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with APC. |
 Polyclonal Antibody (Mouse), Biotinylated) Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), Biotinylated |
|
4-PAD038Mu08-Biotin |
Cloud-Clone |
-
EUR 379.20
-
EUR 3031.20
-
EUR 892.80
-
EUR 464.40
-
EUR 265.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with Biotin. |
 Polyclonal Antibody (Mouse), Cy3) Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), Cy3 |
|
4-PAD038Mu08-Cy3 |
Cloud-Clone |
-
EUR 512.40
-
EUR 5334.00
-
EUR 1446.00
-
EUR 668.40
-
EUR 304.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with Cy3. |
 Polyclonal Antibody (Mouse), FITC) Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), FITC |
|
4-PAD038Mu08-FITC |
Cloud-Clone |
-
EUR 361.20
-
EUR 3254.40
-
EUR 921.60
-
EUR 454.80
-
EUR 236.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with FITC. |
 Polyclonal Antibody (Mouse), HRP) Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), HRP |
|
4-PAD038Mu08-HRP |
Cloud-Clone |
-
EUR 385.20
-
EUR 3519.60
-
EUR 992.40
-
EUR 486.00
-
EUR 250.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with HRP. |
 Polyclonal Antibody (Mouse), PE) Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), PE |
|
4-PAD038Mu08-PE |
Cloud-Clone |
-
EUR 361.20
-
EUR 3254.40
-
EUR 921.60
-
EUR 454.80
-
EUR 236.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with PE. |
 Anti-Kappa Light Chain Antibody Clone TB28-2, Unconjugated-100ug |
|
3514-MSM3-P1 |
EnQuireBio |
100ug |
EUR 513.6 |
 Anti-Kappa Light Chain Antibody Clone HP6053 + L1C1, Unconjugated-100ug |
|
3514-MSM5-P1 |
EnQuireBio |
100ug |
EUR 513.6 |
 Anti-Kappa Light Chain Antibody Clone Kap-56, Unconjugated-100ug |
|
3514-MSM7-P1 |
EnQuireBio |
100ug |
EUR 513.6 |
 Anti-CD314 Antibody [CX5], Unconjugated-100ug |
|
QAB100-100ug |
EnQuireBio |
100ug |
EUR 218.4 |
 Anti-CD4 Antibody [OKT4], Unconjugated-100ug |
|
QAB11-100ug |
EnQuireBio |
100ug |
EUR 147.6 |
 Anti-CD8a Antibody [Hit8a], Unconjugated-100ug |
|
QAB20-100ug |
EnQuireBio |
100ug |
EUR 178.8 |
 Anti-CD11c Antibody [N418], Unconjugated-100ug |
|
QAB23-100ug |
EnQuireBio |
100ug |
EUR 188.4 |
 Anti-CD11c Antibody [3.9], Unconjugated-100ug |
|
QAB24-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD11b Antibody [ICRF44], Unconjugated-100ug |
|
QAB25-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD19 Antibody [1D3], Unconjugated-100ug |
|
QAB28-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD3 Antibody [17A2], Unconjugated-100ug |
|
QAB3-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD25 Antibody [PC61.5], Unconjugated-100ug |
|
QAB34-100ug |
EnQuireBio |
100ug |
EUR 147.6 |
 Anti-CD25 Antibody [BC96], Unconjugated-100ug |
|
QAB35-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD27 Antibody [O323], Unconjugated-100ug |
|
QAB36-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD28 Antibody [CD28.2], Unconjugated-100ug |
|
QAB37-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD45.1 Antibody [A20], Unconjugated-100ug |
|
QAB42-100ug |
EnQuireBio |
100ug |
EUR 188.4 |
 Anti-CD45.2 Antibody [104], Unconjugated-100ug |
|
QAB43-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD45RO Antibody [UCHL1], Unconjugated-100ug |
|
QAB44-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD45RA Antibody [HI100], Unconjugated-100ug |
|
QAB45-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD45 Antibody [HI30], Unconjugated-100ug |
|
QAB46-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD3 Antibody [OKT3], Unconjugated-100ug |
|
QAB5-100ug |
EnQuireBio |
100ug |
EUR 178.8 |
 Anti-CD3 Antibody [UCHT1], Unconjugated-100ug |
|
QAB6-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD8a Antibody [2.43], Unconjugated-100ug |
|
QAB61-100ug |
EnQuireBio |
100ug |
EUR 178.8 |
 Anti-CD3 Antibody [Hit3a], Unconjugated-100ug |
|
QAB7-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-KLRG1 Antibody [2F1], Unconjugated-100ug |
|
QAB74-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD161 Antibody [PK136], Unconjugated-100ug |
|
QAB78-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD4 Antibody [GK1.5], Unconjugated-100ug |
|
QAB8-100ug |
EnQuireBio |
100ug |
EUR 147.6 |
 Anti-CD32 Antibody [2.4G2], Unconjugated-100ug |
|
QAB87-100ug |
EnQuireBio |
100ug |
EUR 169.2 |
 Anti-CD28 Antibody [37.51], Unconjugated-100ug |
|
QAB99-100ug |
EnQuireBio |
100ug |
EUR 178.8 |
 Polyclonal Goat anti-GST α-form |
|
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 336 |
 Polyclonal Goat anti-GST μ-form |
|
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 336 |
 Polyclonal Goat anti-GST p-form |
|
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 336 |
 Anti-Kappa antibody |
|
STJ160049 |
St John's Laboratory |
1 mL C |
EUR 282 |
|
Description: Anti-Kappa recognizes surface immunoglobulin on normal and neoplastic B-cells, and has been indicated as a potential aid in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas, where the expression of a single light chain class is restricted. The determination of light chain ratio is critical in evaluating B-cell neoplasms, as the majority of B-cell lymphomas express either kappa or lambda light chains, while a mixture of kappa and lambda is characteristic of reactive proliferations. In paraffin-embedded tissue, Anti-Kappa displays strong staining of kappa-positive plasma cells, as well as cells that have absorbed exogenous immunoglobulins. |
 Recombinant Human Immunoglobulin lambda-like polypeptide 5 Protein, His, Yeast-100ug |
|
QP9714-ye-100ug |
EnQuireBio |
100ug |
EUR 576 |
 Kappa Light Chain MonoSpecific Antibody, Unconjugated-100ug |
|
3514-MSM11-P1 |
EnQuireBio |
100ug |
EUR 513.6 |
 Recombinant Human Nuclear factor NF-kappa-B p105 subunit Protein, GST, E.coli-100ug |
|
QP8688-ec-100ug |
EnQuireBio |
100ug |
EUR 489.6 |
 Anti-c-Myc Antibody [9E10], Unconjugated-100ug |
|
QAB102-100ug |
EnQuireBio |
100ug |
EUR 259.2 |
 Anti-CD4 Antibody [RPA-T4], Unconjugated-100ug |
|
QAB12-100ug |
EnQuireBio |
100ug |
EUR 147.6 |
 Anti-CD8a Antibody [53-6.7], Unconjugated-100ug |
|
QAB16-100ug |
EnQuireBio |
100ug |
EUR 157.2 |
 Anti-CD8a Antibody [RPA-T8], Unconjugated-100ug |
|
QAB19-100ug |
EnQuireBio |
100ug |
EUR 178.8 |
 Anti-CD3e Antibody [145-2C11], Unconjugated-100ug |
|
QAB2-100ug |
EnQuireBio |
100ug |
EUR 147.6 |
 Anti-CD45 Antibody [30-F11], Unconjugated-100ug |
|
QAB40-100ug |
EnQuireBio |
100ug |
EUR 178.8 |
 Anti-CD80 Antibody [16-10A1], Unconjugated-100ug |
|
QAB50-100ug |
EnQuireBio |
100ug |
EUR 218.4 |
 Anti-CD86 Antibody [GL-1], Unconjugated-100ug |
|
QAB51-100ug |
EnQuireBio |
100ug |
EUR 188.4 |
 Anti-CD161 Antibody [HP-3G10], Unconjugated-100ug |
|
QAB60-100ug |
EnQuireBio |
100ug |
EUR 188.4 |
 Anti-IL-4 Antibody [11B11], Unconjugated-100ug |
|
QAB81-100ug |
EnQuireBio |
100ug |
EUR 178.8 |
 Anti-FCER1A Antibody [MAR-1], Unconjugated-100ug |
|
QAB91-100ug |
EnQuireBio |
100ug |
EUR 218.4 |
 Antibody) Kappa Casein (CSN3) Antibody |
|
abx232019-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
|
Conclusions: Intracellular circulation cytometry might be routinely employed to discover alterations within the PI3K-Akt-mTOR pathway in B cells from sufferers with PADs. AKT and S6 phosphorylation ranges are informative biomarkers that may very well be employed as mTOR inhibitors for monitoring therapies focusing on this pathway.
