Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling
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December 10, 2020

Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling

By Charles
Introduction and targets: The activation of hepatic stellate cells (HSCs) is the primary reason for liver fibrosis. The useful results of fibroblast development issue (FGF) 19 on liver fibrosis had been not too long ago reported. The S. miltiorrhiza in addition to S. miltiorrhiza derived bioactive chemical parts has proven distinguished antifibrotic results in liver fibrosis however the mechanism continues to be not totally understood. We aimed to research the bioactive compounds derived from S. miltiorrhiza which exerts antifibrotic results in HSCs through regulating FGF19.
Supplies and strategies: FGF19 stage in tradition media was decided by enzyme-linked immunosorbent assay. Cell proliferation was measured by Cell Counting Package-Eight assay. Additional, mRNA and protein expressions had been assessed by quantitative polymerase chain response and western blotting, respectively. Pulling down of FGF receptor 4 (FGFR4) by transfection with siRNA was used to substantiate the function of FGF19/FGFR4 signaling.
Outcomes: Utilizing the human HSC cell line LX-2, we screened a number of pure merchandise and located that bioactive compounds remoted from Salvia miltiorrhiza, notably salvianolic acid B, strongly upregulated FGF19 secretion by LX-2 cells. We additional confirmed that salvianolic acid B inhibited lipopolysaccharide (LPS)-induced HSC proliferation and activation. LPS remedy might also cut back the mRNA and protein ranges of FGF19 and its receptor FGFR4. Salvianolic acid B remedy restored the impaired expressions of FGF19 and FGFR4. Lastly, FGFR4 knockdown abolished the antifibrotic results of salvianolic acid B within the LPS-induced HSC activation mannequin.
Conclusions: Salvianolic acid B prevented LPS-induced HSC proliferation and activation by enhancing antifibrotic FGF19/FGFR4 signaling.

Glutaredoxin deficiency promotes activation of the reworking development issue beta pathway in airway epithelial cells, in affiliation with fibrotic airway transforming

S-glutathionylation of reactive protein cysteines is a post-translational occasion that performs a important function in transducing indicators from oxidants into organic responses. S-glutathionylation might be reversed by the deglutathionylating enzyme glutaredoxin (GLRX). Now we have beforehand demonstrated that ablation of Glrx sensitizes mice to the event of parenchymal lung fibrosis(1). It stays unclear whether or not GLRX additionally controls airway fibrosis, a scientific function related to bronchial asthma and continual obstructive pulmonary illness, and whether or not GLRX controls the biology of airway epithelial cells, which have been implicated within the pathophysiology of those ailments.
Within the current examine we utilized a home mud mite (HDM) mannequin of allergic airway illness in wild sort (WT) and Glrx-/- mice on a C57BL/6 background susceptible to develop airway fibrosis, and tracheal basal stem cells derived from WT mice, international Glrx-/- mice, or bi-transgenic mice permitting conditional ablation of the Glrx gene. Herein we present that absence of Glrx led to enhanced HDM-induced collagen deposition, elevated ranges of reworking development issue beta 1 (TGFB1) within the bronchoalveolar lavage, and resulted in will increase in airway hyperresponsiveness. Airway epithelial cells remoted from Glrx-/- mice or following conditional ablation of Glrx confirmed spontaneous will increase in secretion of TGFB1. Glrx-/- basal cells additionally confirmed spontaneous TGFB pathway activation, in affiliation with elevated expression of mesenchymal genes, together with collagen 1a1 and fibronectin. Total, these findings counsel that GLRX regulates airway fibrosis through a mechanism(s) that contain the plasticity of basal cells, the stem cells of the airways.
The outbreak of the 2019 coronavirus illness (named, COVID‑19), brought on by the novel SARS‑CoV‑2 virus, represents a worldwide extreme risk to public well being. It’s of the utmost significance to characterize the immune responses towards the SARS‑CoV‑2 and the mechanisms of hyperinflammation, to be able to design higher therapeutic methods for COVID‑19. Within the current examine, a transcriptomic evaluation was carried out to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID‑19 sufferers and controls. Our information concordantly revealed elevated humoral responses to an infection. The elucidation of the host responses to SARS‑CoV‑2 an infection could additional enhance our understanding of COVID‑19 pathogenesis and counsel higher therapeutic methods.
Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling

Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling

Analysis of B–cell intracellular signaling by monitoring the PI3K-Akt axis in sufferers with frequent variable immunodeficiency and activated phosphoinositide 3-kinase delta syndrome

Background: Major antibody deficiencies (PADs) are characterised by hypogammaglobulinemia and impaired B-cell differentiation. Sufferers with frequent variable immunodeficiency (CVID) current extreme reductions in not less than 2 serum immunoglobulins and impaired terminal differentiation of B cells. Most sufferers with CVID don’t seem to current monogenic defects. Activated phosphoinositide 3-kinase delta syndrome (APDS), brought on by gain-of-function mutations within the PIK3CD gene (p110δ), can current in sufferers with a CVID-like phenotype. Reminiscence B-cell differentiation requires the orchestrated activation of quite a few intracellular signaling pathways, which promote transcriptional packages required for long-term B-cell survival. The goal of this examine was to develop a circulation cytometry assay to hint the PI3K-Akt-mTOR pathway, a important part of B-cell homeostasis, and analyze its standing in PADs.
Strategies: We analyzed the intracellular expression of Akt and S6 by circulation cytometry and their phosphorylation standing in each baseline circumstances and upon B-cell receptor activation with anti-IgM in numerous main B-cell subsets of sufferers with CVID and APDS.
Outcomes: B cells from CVID sufferers confirmed decreased phosphorylation in Akt and S6 proteins after anti-IgM stimulation. Constitutive excessive baseline B-cell ranges of Akt and S6 phosphorylation in a affected person with APDS had been decreased as soon as m-TOR inhibition remedy was initiated.

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Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
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EUR 925

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
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Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
MBS6131954-01mL 0.1(mL
EUR 875

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
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EUR 925

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (APC)
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EUR 4000

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (Biotin)
MBS6127570-01mL 0.1(mL
EUR 925

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (Biotin)
MBS6127570-5x01mL 5x0.1mL
EUR 4000

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (FITC)
MBS6128184-01mL 0.1(mL
EUR 925

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (FITC)
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EUR 4000

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
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EUR 875

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EUR 875

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EUR 3800

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
MBS6158469-01mL 0.1(mL
EUR 875

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
MBS6158469-5x01mL 5x0.1mL
EUR 3800

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (Biotin)
MBS6249096-01mL 0.1(mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (Biotin)
MBS6249096-5x01mL 5x0.1mL
EUR 5270

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (FITC)
MBS6250016-01mL 0.1(mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (FITC)
MBS6250016-5x01mL 5x0.1mL
EUR 5270

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
MBS6251017-01mL 0.1(mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
MBS6251017-5x01mL 5x0.1mL
EUR 5270

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
MBS6248081-01mL 0.1(mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
MBS6248081-5x01mL 5x0.1mL
EUR 5270

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
MBS6260372-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
MBS6260372-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
MBS6260373-01mL 0.1mL
EUR 1435

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (AP)
MBS6260373-5x01mL 5x0.1mL
EUR 6310

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (FITC)
MBS6261902-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (FITC)
MBS6261902-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (FITC)
MBS6261903-01mL 0.1mL
EUR 1435

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (FITC)
MBS6261903-5x01mL 5x0.1mL
EUR 6310

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
MBS6262412-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
MBS6262412-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
MBS6262413-01mL 0.1mL
EUR 1435

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
MBS6262413-5x01mL 5x0.1mL
EUR 6310

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
MBS6262923-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
MBS6262923-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
MBS6262924-01mL 0.1mL
EUR 1435

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
MBS6262924-5x01mL 5x0.1mL
EUR 6310

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (APC)
MBS6260883-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (APC)
MBS6260883-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (APC)
MBS6260884-01mL 0.1mL
EUR 1435

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (APC)
MBS6260884-5x01mL 5x0.1mL
EUR 6310

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (Biotin)
MBS6261394-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (Biotin)
MBS6261394-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (Biotin)
MBS6261395-01mL 0.1mL
EUR 1435

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (Biotin)
MBS6261395-5x01mL 5x0.1mL
EUR 6310

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
MBS6251970-01mL 0.1(mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (PE)
MBS6251970-5x01mL 5x0.1mL
EUR 5270

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (APC)
MBS6268935-01mL 0.1mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (APC)
MBS6268935-5x01mL 5x0.1mL
EUR 5270

Mouse Immunoglobulin kappa Peptide (OVA)
abx165553-100g 100 µg
EUR 2062.5

Mouse Immunoglobulin kappa Peptide (OVA)
abx165553-10g 10 µg
EUR 537.5

Mouse Immunoglobulin kappa Peptide (OVA)
abx165553-50g 50 µg
EUR 637.5

Kappa, Lambda Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
MBS609443-05mg 0.5mg
EUR 1190

Kappa, Lambda Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (HRP)
MBS609443-5x05mg 5x0.5mg
EUR 5215

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)
MBS6201492-01mL 0.1(mL
EUR 875

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)
MBS6201492-5x01mL 5x0.1mL
EUR 3800

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 550)
MBS6212167-01mL 0.1(mL
EUR 875

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 550)
MBS6212167-5x01mL 5x0.1mL
EUR 3800

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 405)
MBS6190817-01mL 0.1(mL
EUR 875

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 405)
MBS6190817-5x01mL 5x0.1mL
EUR 3800

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)
MBS6254030-01mL 0.1(mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)
MBS6254030-5x01mL 5x0.1mL
EUR 5270

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 550)
MBS6255070-01mL 0.1(mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 550)
MBS6255070-5x01mL 5x0.1mL
EUR 5270

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 405)
MBS6252990-01mL 0.1(mL
EUR 1205

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 405)
MBS6252990-5x01mL 5x0.1mL
EUR 5270

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)
MBS6263945-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)
MBS6263945-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)
MBS6263946-01mL 0.1mL
EUR 1435

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)
MBS6263946-5x01mL 5x0.1mL
EUR 6310

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 550)
MBS6264456-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 550)
MBS6264456-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 550)
MBS6264457-01mL 0.1mL
EUR 1435

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 550)
MBS6264457-5x01mL 5x0.1mL
EUR 6310

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 650)
MBS6264967-01mL 0.1mL
EUR 1065

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 650)
MBS6264967-5x01mL 5x0.1mL
EUR 4635

Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 650)
MBS6264968-01mL 0.1mL
EUR 1435
Conclusions: Intracellular circulation cytometry might be routinely employed to discover alterations within the PI3K-Akt-mTOR pathway in B cells from sufferers with PADs. AKT and S6 phosphorylation ranges are informative biomarkers that may very well be employed as mTOR inhibitors for monitoring therapies focusing on this pathway.
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