Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling
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December 10, 2020

Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling

By Charles
Introduction and targets: The activation of hepatic stellate cells (HSCs) is the primary reason for liver fibrosis. The useful results of fibroblast development issue (FGF) 19 on liver fibrosis had been not too long ago reported. The S. miltiorrhiza in addition to S. miltiorrhiza derived bioactive chemical parts has proven distinguished antifibrotic results in liver fibrosis however the mechanism continues to be not totally understood. We aimed to research the bioactive compounds derived from S. miltiorrhiza which exerts antifibrotic results in HSCs through regulating FGF19.
Supplies and strategies: FGF19 stage in tradition media was decided by enzyme-linked immunosorbent assay. Cell proliferation was measured by Cell Counting Package-Eight assay. Additional, mRNA and protein expressions had been assessed by quantitative polymerase chain response and western blotting, respectively. Pulling down of FGF receptor 4 (FGFR4) by transfection with siRNA was used to substantiate the function of FGF19/FGFR4 signaling.
Outcomes: Utilizing the human HSC cell line LX-2, we screened a number of pure merchandise and located that bioactive compounds remoted from Salvia miltiorrhiza, notably salvianolic acid B, strongly upregulated FGF19 secretion by LX-2 cells. We additional confirmed that salvianolic acid B inhibited lipopolysaccharide (LPS)-induced HSC proliferation and activation. LPS remedy might also cut back the mRNA and protein ranges of FGF19 and its receptor FGFR4. Salvianolic acid B remedy restored the impaired expressions of FGF19 and FGFR4. Lastly, FGFR4 knockdown abolished the antifibrotic results of salvianolic acid B within the LPS-induced HSC activation mannequin.
Conclusions: Salvianolic acid B prevented LPS-induced HSC proliferation and activation by enhancing antifibrotic FGF19/FGFR4 signaling.

Glutaredoxin deficiency promotes activation of the reworking development issue beta pathway in airway epithelial cells, in affiliation with fibrotic airway transforming

S-glutathionylation of reactive protein cysteines is a post-translational occasion that performs a important function in transducing indicators from oxidants into organic responses. S-glutathionylation might be reversed by the deglutathionylating enzyme glutaredoxin (GLRX). Now we have beforehand demonstrated that ablation of Glrx sensitizes mice to the event of parenchymal lung fibrosis(1). It stays unclear whether or not GLRX additionally controls airway fibrosis, a scientific function related to bronchial asthma and continual obstructive pulmonary illness, and whether or not GLRX controls the biology of airway epithelial cells, which have been implicated within the pathophysiology of those ailments.
Within the current examine we utilized a home mud mite (HDM) mannequin of allergic airway illness in wild sort (WT) and Glrx-/- mice on a C57BL/6 background susceptible to develop airway fibrosis, and tracheal basal stem cells derived from WT mice, international Glrx-/- mice, or bi-transgenic mice permitting conditional ablation of the Glrx gene. Herein we present that absence of Glrx led to enhanced HDM-induced collagen deposition, elevated ranges of reworking development issue beta 1 (TGFB1) within the bronchoalveolar lavage, and resulted in will increase in airway hyperresponsiveness. Airway epithelial cells remoted from Glrx-/- mice or following conditional ablation of Glrx confirmed spontaneous will increase in secretion of TGFB1. Glrx-/- basal cells additionally confirmed spontaneous TGFB pathway activation, in affiliation with elevated expression of mesenchymal genes, together with collagen 1a1 and fibronectin. Total, these findings counsel that GLRX regulates airway fibrosis through a mechanism(s) that contain the plasticity of basal cells, the stem cells of the airways.
The outbreak of the 2019 coronavirus illness (named, COVID‑19), brought on by the novel SARS‑CoV‑2 virus, represents a worldwide extreme risk to public well being. It’s of the utmost significance to characterize the immune responses towards the SARS‑CoV‑2 and the mechanisms of hyperinflammation, to be able to design higher therapeutic methods for COVID‑19. Within the current examine, a transcriptomic evaluation was carried out to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID‑19 sufferers and controls. Our information concordantly revealed elevated humoral responses to an infection. The elucidation of the host responses to SARS‑CoV‑2 an infection could additional enhance our understanding of COVID‑19 pathogenesis and counsel higher therapeutic methods.
Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling

Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling

Analysis of B–cell intracellular signaling by monitoring the PI3K-Akt axis in sufferers with frequent variable immunodeficiency and activated phosphoinositide 3-kinase delta syndrome

Background: Major antibody deficiencies (PADs) are characterised by hypogammaglobulinemia and impaired B-cell differentiation. Sufferers with frequent variable immunodeficiency (CVID) current extreme reductions in not less than 2 serum immunoglobulins and impaired terminal differentiation of B cells. Most sufferers with CVID don’t seem to current monogenic defects. Activated phosphoinositide 3-kinase delta syndrome (APDS), brought on by gain-of-function mutations within the PIK3CD gene (p110δ), can current in sufferers with a CVID-like phenotype. Reminiscence B-cell differentiation requires the orchestrated activation of quite a few intracellular signaling pathways, which promote transcriptional packages required for long-term B-cell survival. The goal of this examine was to develop a circulation cytometry assay to hint the PI3K-Akt-mTOR pathway, a important part of B-cell homeostasis, and analyze its standing in PADs.
Strategies: We analyzed the intracellular expression of Akt and S6 by circulation cytometry and their phosphorylation standing in each baseline circumstances and upon B-cell receptor activation with anti-IgM in numerous main B-cell subsets of sufferers with CVID and APDS.
Outcomes: B cells from CVID sufferers confirmed decreased phosphorylation in Akt and S6 proteins after anti-IgM stimulation. Constitutive excessive baseline B-cell ranges of Akt and S6 phosphorylation in a affected person with APDS had been decreased as soon as m-TOR inhibition remedy was initiated.

Mouse Immunoglobulin E Kappa (IgE Kappa) Protein
abx670299-05mg 0.5 mg
EUR 727.2

Immunoglobulin Kappa (Igk) Antibody (PE)
20-abx270852
  • EUR 794.40
  • EUR 927.60
  • EUR 427.20
  • EUR 1479.60
  • EUR 560.40
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Immunoglobulin Kappa (Igk) Antibody (PE)
20-abx274585
  • EUR 594.00
  • EUR 309.60
  • EUR 1746.00
  • EUR 811.20
  • EUR 477.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Immunoglobulin kappa Protein (OVA)
20-abx165553
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Immunoglobulin G1 Kappa (IgG1 Kappa) Protein
abx670165-1mg 1 mg
EUR 560.4

Human Immunoglobulin G2 Kappa (IgG2 Kappa) Protein
abx670166-1mg 1 mg
EUR 627.6

Mouse Immunoglobulin G1 Kappa (IgG1 Kappa) Protein
abx670291-1mg 1 mg
EUR 760.8

Immunoglobulin Kappa (Igk) Antibody (APC)
20-abx270620
  • EUR 910.80
  • EUR 1078.80
  • EUR 460.80
  • EUR 1746.00
  • EUR 644.40
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Immunoglobulin Kappa (Igk) Antibody (APC)
20-abx274586
  • EUR 678.00
  • EUR 326.40
  • EUR 2131.20
  • EUR 978.00
  • EUR 543.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Immunoglobulin Kappa (Igk) Antibody (FITC)
20-abx270388
  • EUR 678.00
  • EUR 794.40
  • EUR 376.80
  • EUR 1228.80
  • EUR 493.20
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Immunoglobulin Kappa (Igk) Antibody Pair
20-abx370695
  • EUR 2148.00
  • EUR 1362.00
  • 10 × 96 tests
  • 5 × 96 tests

Immunoglobulin Kappa (Igk) Antibody (APC/Cy7)
20-abx274584
  • EUR 1161.60
  • EUR 493.20
  • EUR 4051.20
  • EUR 1746.00
  • EUR 878.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Immunoglobulin M Kappa (IgM) Antibody
20511-05011 150 ug
EUR 260.4

Mouse Immunoglobulin G2a Kappa (IgG2a Kappa) Protein
abx670292-1mg 1 mg
EUR 760.8

Mouse Immunoglobulin G2b Kappa (IgG2b Kappa) Protein
abx670293-1mg 1 mg
EUR 760.8

Immunoglobulin Kappa (Igk) Polyclonal Antibody
CAU31617-100ul 100ul
EUR 258.2

Immunoglobulin Kappa (Igk) Polyclonal Antibody
CAU31617-200ul 200ul
EUR 322.6

Immunoglobulin Kappa (Igk) Polyclonal Antibody
CAU29980-100ul 100ul
EUR 241.9

Immunoglobulin Kappa (Igk) Polyclonal Antibody
CAU29980-200ul 200ul
EUR 302.4

OVA Conjugated Immunoglobulin Kappa (Igk)
4-CPD038Hu21
  • EUR 492.02
  • EUR 254.40
  • EUR 1515.07
  • EUR 585.02
  • EUR 1050.05
  • EUR 404.40
  • EUR 3607.68
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Immunoglobulin Kappa expressed in: Protein conjugation

OVA Conjugated Immunoglobulin Kappa (Igk)
4-CPD038Mu21
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Immunoglobulin Kappa expressed in: chemical synthesis

OVA Conjugated Immunoglobulin Kappa (Igk)
RPU51657-100ug 100ug
EUR 492.8

OVA Conjugated Immunoglobulin Kappa (Igk)
RPU51657-1mg 1mg
EUR 2184

OVA Conjugated Immunoglobulin Kappa (Igk)
RPU51657-50ug 50ug
EUR 384

OVA Conjugated Immunoglobulin Kappa (Igk)
RPU55072-100ug 100ug
EUR 426.8

OVA Conjugated Immunoglobulin Kappa (Igk)
RPU55072-1mg 1mg
EUR 1888.9

OVA Conjugated Immunoglobulin Kappa (Igk)
RPU55072-50ug 50ug
EUR 332.2

Human Immunoglobulin Kappa (Igk) CLIA Kit
20-abx494060
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Immunoglobulin Kappa (Igk) CLIA Kit
20-abx496452
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
20-abx258908
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Immunoglobulin Kappa (Igk) ELISA Kit
20-abx156942
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Immunoglobulin Kappa (Igk) ELISA Kit
SED038Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immunoglobulin Kappa (Igk) in serum, plasma and other biological fluids.

Human Immunoglobulin Kappa (Igk) ELISA Kit
SED038Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immunoglobulin Kappa (Igk) in serum, plasma and other biological fluids.

Human Immunoglobulin Kappa (Igk) ELISA Kit
SED038Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immunoglobulin Kappa (Igk) in serum, plasma and other biological fluids.

Human Immunoglobulin Kappa (Igk) ELISA Kit
SED038Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Immunoglobulin Kappa (Igk) in serum, plasma and other biological fluids.

Human Immunoglobulin Kappa (Igk) ELISA Kit
4-SED038Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Immunoglobulin Kappa (Igk) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
SED038Mu-10x96wellstestplate 10x96-wells test plate
EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immunoglobulin Kappa (Igk) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
SED038Mu-1x48wellstestplate 1x48-wells test plate
EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immunoglobulin Kappa (Igk) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
SED038Mu-1x96wellstestplate 1x96-wells test plate
EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immunoglobulin Kappa (Igk) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
SED038Mu-5x96wellstestplate 5x96-wells test plate
EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Immunoglobulin Kappa (Igk) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
4-SED038Mu
  • EUR 5895.60
  • EUR 3114.00
  • EUR 786.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Immunoglobulin Kappa (Igk) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Immunoglobulin Kappa(Igk)ELISA Kit
QY-E02169 96T
EUR 433.2

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
EKN52108-48T 48T
EUR 355.6

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
EKN52108-5x96T 5x96T
EUR 2413

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
EKN52108-96T 96T
EUR 508

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
EKU10997-48T 48T
EUR 571.55

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
EKU10997-5x96T 5x96T
EUR 3878.38

Mouse Immunoglobulin Kappa (Igk) ELISA Kit
EKU10997-96T 96T
EUR 816.5

Human Immunoglobulin Kappa (Igk) ELISA Kit
EKU09146-48T 48T
EUR 555.66

Human Immunoglobulin Kappa (Igk) ELISA Kit
EKU09146-5x96T 5x96T
EUR 3770.55

Human Immunoglobulin Kappa (Igk) ELISA Kit
EKU09146-96T 96T
EUR 793.8

Human Immunoglobulin Kappa (Igk) ELISA Kit
EKN50257-48T 48T
EUR 345.73

Human Immunoglobulin Kappa (Igk) ELISA Kit
EKN50257-5x96T 5x96T
EUR 2346.03

Human Immunoglobulin Kappa (Igk) ELISA Kit
EKN50257-96T 96T
EUR 493.9

Human Igk(Immunoglobulin Kappa) ELISA Kit
ELK5262-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Igk. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Igk. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human Igk, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human Igk in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Igk(Immunoglobulin Kappa) ELISA Kit
ELK5262-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Igk. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Igk. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human Igk, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human Igk in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse Igk(Immunoglobulin Kappa) ELISA Kit
ELK7759-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Igk. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Igk. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse Igk, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse Igk in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse Igk(Immunoglobulin Kappa) ELISA Kit
ELK7759-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Igk. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Igk. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse Igk, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse Igk in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Immunoglobulin Kappa (Igk) Protein (OVA)
20-abx651861
  • EUR 693.60
  • EUR 309.60
  • EUR 2047.20
  • EUR 811.20
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse)
4-PAD038Mu08
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk)

ELISA kit for Mouse Igk (Immunoglobulin Kappa)
ELK7759 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Immunoglobulin Kappa from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human Igk (Immunoglobulin Kappa)
ELK5262 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Immunoglobulin Kappa from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), PE
4-PAD038Mu08-PE
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with PE.

Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), APC
4-PAD038Mu08-APC
  • EUR 421.20
  • EUR 4038.00
  • EUR 1122.00
  • EUR 538.80
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with APC.

Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), Cy3
4-PAD038Mu08-Cy3
  • EUR 512.40
  • EUR 5334.00
  • EUR 1446.00
  • EUR 668.40
  • EUR 304.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with Cy3.

Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), HRP
4-PAD038Mu08-HRP
  • EUR 385.20
  • EUR 3519.60
  • EUR 992.40
  • EUR 486.00
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with HRP.

Immunoglobulin Kappa Variable 1-5 (IGKV1-5) Antibody
abx234188-100ug 100 ug
EUR 610.8

Immunoglobulin Kappa Variable 1-5 (IGKV1-5) Antibody
20-abx113111
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), FITC
4-PAD038Mu08-FITC
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with FITC.

Immunoglobulin Kappa (Igk) Magnetic Luminex Assay Kit
LKU607576-96T 96T
EUR 966

Immunoglobulin Kappa (Igk) Magnetic Luminex Assay Kit
LKU607578-96T 96T
EUR 993.6

Dog Kappa immunoglobulin light chain ELISA kit
E08K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Kappa immunoglobulin light chain ELISA kit
E08K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Kappa immunoglobulin light chain ELISA kit
E08K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Kappa immunoglobulin light chain ELISA kit
E02K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Kappa immunoglobulin light chain ELISA kit
E02K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Kappa immunoglobulin light chain ELISA kit
E02K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Kappa immunoglobulin light chain ELISA kit
E07K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Kappa immunoglobulin light chain ELISA kit
E07K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Kappa immunoglobulin light chain ELISA kit
E07K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Kappa immunoglobulin light chain ELISA kit
E06K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Kappa immunoglobulin light chain ELISA kit
E06K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Kappa immunoglobulin light chain ELISA kit
E06K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Immunoglobulin M Kappa (IgM) Antibody (Biotin Conjugate)
20511-05021 150 ug
EUR 331.2

Mouse Kappa immunoglobulin light chain ELISA kit
E03K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Kappa immunoglobulin light chain ELISA kit
E03K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Kappa immunoglobulin light chain ELISA kit
E03K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Kappa immunoglobulin light chain ELISA kit
E01K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Kappa immunoglobulin light chain ELISA kit
E01K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Kappa immunoglobulin light chain ELISA kit
E01K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human kappa immunoglobulin light chain ELISA Kit
ELA-E0644h 96 Tests
EUR 988.8

Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), APC-Cy7
4-PAD038Mu08-APC-Cy7
  • EUR 699.60
  • EUR 7932.00
  • EUR 2100.00
  • EUR 933.60
  • EUR 388.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with APC-Cy7.

Rabbit Kappa immunoglobulin light chain ELISA kit
E04K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Kappa immunoglobulin light chain ELISA kit
E04K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Kappa immunoglobulin light chain ELISA kit
E04K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Kappa immunoglobulin light chain ELISA kit
E09K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Kappa immunoglobulin light chain ELISA kit
E09K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Kappa immunoglobulin light chain ELISA kit
E09K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Immunoglobulin Kappa (Igk) Polyclonal Antibody (Mouse), Biotinylated
4-PAD038Mu08-Biotin
  • EUR 379.20
  • EUR 3031.20
  • EUR 892.80
  • EUR 464.40
  • EUR 265.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Immunoglobulin Kappa (Igk). This antibody is labeled with Biotin.

Human kappa immunoglobulin light chain,?-IgLC ELISA Kit
201-12-1698 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Guinea pig Kappa immunoglobulin light chain ELISA kit
E05K0067-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Kappa immunoglobulin light chain ELISA kit
E05K0067-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Kappa immunoglobulin light chain ELISA kit
E05K0067-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Kappa immunoglobulin light chain in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Immunoglobulin M Kappa (IgM) AssayLite Antibody (FITC Conjugate)
20511-05041 150 ug
EUR 513.6

Mouse Immunoglobulin M Kappa (IgM) AssayLite Antibody (RPE Conjugate)
20511-05051 150 ug
EUR 513.6

Mouse Immunoglobulin M Kappa (IgM) AssayLite Antibody (APC Conjugate)
20511-05061 150 ug
EUR 513.6

Human Immunoglobulin Kappa Variable 1-5 (IGKV1-5) ELISA Kit
abx387966-96tests 96 tests
EUR 1093.2

Rat Kappa immunoglobulin light chain(κ-IgLC) ELISA Kit
NSL0409r 96 Tests
EUR 498

Human Immunoglobulin kappa variable 3-11(IGKV3-11) ELISA kit
YLA4363HU-48T 48T
EUR 435

Human Immunoglobulin kappa variable 3-11(IGKV3-11) ELISA kit
YLA4363HU-96T 96T
EUR 562.5

Mouse Immunoglobulin M Kappa (IgM) AssayLite Antibody (PerCP Conjugate)
20511-05071 150 ug
EUR 565.2

Goat Kappa immunoglobulin light chain(κ-IgLC) ELISA Kit
NSL1066Gt 96T
EUR 528

Human kappa immunoglobulin light chain,κ-IgLC ELISA Kit
CN-03792H1 96T
EUR 573.6

Human kappa immunoglobulin light chain,κ-IgLC ELISA Kit
CN-03792H2 48T
EUR 394.8

Human kappa immunoglobulin light chain(κ-IgLC)ELISA Kit
GA-E1714HM-48T 48T
EUR 346.8

Human kappa immunoglobulin light chain(κ-IgLC)ELISA Kit
GA-E1714HM-96T 96T
EUR 559.2

Human kappa immunoglobulin light chain,κ-IgLC ELISA Kit
EKC31268-48T 48T
EUR 412.02

Human kappa immunoglobulin light chain,κ-IgLC ELISA Kit
EKC31268-5x96T 5x96T
EUR 2795.85

Human kappa immunoglobulin light chain,κ-IgLC ELISA Kit
EKC31268-96T 96T
EUR 588.6

Human kappa immunoglobulin light chain(κ-IgLC)ELISA Kit
QY-E02166 96T
EUR 433.2

Human kappa immunoglobulin light chain,κ-IgLC ELISA Kit
YLA2728HU-48T 48T
EUR 435

Human kappa immunoglobulin light chain,κ-IgLC ELISA Kit
YLA2728HU-96T 96T
EUR 562.5

Human kappa immunoglobulin light chain( κ-IgLC) ELISA Kit
NSL2216Hu 96 wells
EUR 468

Mouse kappa immunoglobulin light chain( κ-IgLC) ELISA Kit
NSL1607m 96 Test
EUR 528

Human kappa immunoglobulin light chain, κ-IgLC ELISA Kit
CSB-E09247h-24T 1 plate of 24 wells
EUR 198
Description: Quantitative competitive ELISA kit for measuring Human kappa immunoglobulin light chain, κ-IgLC in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human kappa immunoglobulin light chain, κ-IgLC ELISA Kit
1-CSB-E09247h
  • EUR 722.40
  • EUR 5085.60
  • EUR 2707.20
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative competitive ELISA kit for measuring Human kappa immunoglobulin light chain, κ-IgLC in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Kappa immunoglobulin light chain(κ-IgLC) ELISA Kit
NSL0048Bo 96 T
EUR 528

Canine Kappa immunoglobulin light chain(κ-IgLC) ELISA Kit
NSL0073Ca 168 wells
EUR 528

Chicken Kappa immunoglobulin light chain(κ-IgLC) ELISA Kit
NSL1097Ch 1192 T
EUR 528

Porcine Kappa immunoglobulin light chain(κ-IgLC) ELISA Kit
NSL0903Po 96T
EUR 528

ELISA kit for Human kappa immunoglobulin light chain,κ-IgLC
EK0244 96 tests
EUR 854.4
Description: Enzyme-linked immunosorbent assay kit for quantification of Human kappa immunoglobulin light chain,κ-IgLC in samples from serum, plasma, tissue homogenates and other biological fluids.

Guinea pig Kappa immunoglobulin light chain(κ-IgLC) ELISA Kit
NSL1138Gp 96T
EUR 528

Pig Immunoglobulin free light chains kappa and lambda ELISA kit
E07I0047-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Immunoglobulin free light chains kappa and lambda in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Conclusions: Intracellular circulation cytometry might be routinely employed to discover alterations within the PI3K-Akt-mTOR pathway in B cells from sufferers with PADs. AKT and S6 phosphorylation ranges are informative biomarkers that may very well be employed as mTOR inhibitors for monitoring therapies focusing on this pathway.
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