Trimeric Spike Glycoprotein

Lab Reagents

Human IgG antibody Laboratories manufactures the trimeric spike glycoprotein reagents distributed by Genprice. The Trimeric Spike Glycoprotein reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Spike Glycoprotein. Other Trimeric products are available in stock. Specificity: Trimeric Category: Spike Group: Glycoprotein

Glycoprotein information

Coronavirus OC43 Spike glycoprotein Antibody

20-abx109271
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

SARS-CoV-2 (COVID-19) Trimeric Spike (S) Recombinant Protein

10-075 0.1 mg
EUR 991.5
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded, positive-sense RNA virus that belongs to the Coronaviridae family 1. The SARS-CoV-2 genome, which shares 79.6% identity with SARS-CoV, encodes four essential structural proteins: the spike (S), envelope (E), membrane (M), and nucleocapsid protein (N) 2. The S protein is a transmembrane, homotrimeric, class I fusion glycoprotein that mediates viral attachment, fusion, and entry into host cells 3. Each ~180 kDa monomer contains two functional subunits, S1 (~700 a.a) and S2 (~600 a.a), that mediate viral attachment and membrane fusion, respectively. S1 contains two major domains, the N-terminal (NTD) and C-terminal domains (CTD). The CTD contains the receptor-binding domain (RBD), which binds to the angiotensin-converting enzyme 2 (ACE2) receptor on host cells 3-5. Although both SARS-CoV and SARS-CoV-2 bind the ACE2 receptor, the RBDs only share ~73% amino acid identity, and the SARS-CoV-2 RBD binds with a higher affinity compared to SARS-CoV 3, 6. The RBD is dynamic and undergoes hinge-like conformational changes, referred to as the “down” or “up” conformations, which hide or expose the receptor-binding motifs, respectively 7. Following receptor binding, S1 destabilizes, and TMPRSS2 cleaves S2, which undergoes a pre- to post-fusion conformation transition, allowing for membrane fusion 8, 9. The S protein has been the main focus of therapeutic and vaccine design as it is highly immunogenic. Both neutralizing antibodies 10,11 and memory T cells 12,13 targeting the S protein are present in the sera of convalescent COVID-19 patients.

Human coronavirus OC43 Spike glycoprotein (S)

1-CSB-YP336163HIY
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human coronavirus OC43 Spike glycoprotein(S) ,partial expressed in Yeast

Human coronavirus OC43 Spike glycoprotein (S)

1-CSB-EP336163HIY
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human coronavirus OC43 Spike glycoprotein(S) ,partial expressed in E.coli

Coronavirus OC43 Spike glycoprotein Antibody (HRP)

20-abx108122
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Coronavirus OC43 Spike glycoprotein Antibody (Biotin)

20-abx105286
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Coronavirus OC43 Spike glycoprotein Antibody (FITC)

20-abx106705
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Spike Glycoprotein Polyclonal Antibody, HRP Conjugated

A56215-050 50 ul
EUR 302.5

Spike Glycoprotein Polyclonal Antibody, HRP Conjugated

A56215-100 100 ul
EUR 423.5

Spike Glycoprotein Polyclonal Antibody, FITC Conjugated

A56216-050 50 ul
EUR 302.5

Spike Glycoprotein Polyclonal Antibody, FITC Conjugated

A56216-100 100 ul
EUR 423.5

Spike Glycoprotein Polyclonal Antibody, Biotin Conjugated

A56217-050 50 ul
EUR 302.5

Spike Glycoprotein Polyclonal Antibody, Biotin Conjugated

A56217-100 100 ul
EUR 423.5

Spike Glycoprotein Polyclonal Antibody, HRP Conjugated

A57202-050 50 ul
EUR 302.5

Spike Glycoprotein Polyclonal Antibody, HRP Conjugated

A57202-100 100 ul
EUR 423.5

Spike Glycoprotein Polyclonal Antibody, FITC Conjugated

A57203-050 50 ul
EUR 302.5

Spike Glycoprotein Polyclonal Antibody, FITC Conjugated

A57203-100 100 ul
EUR 423.5