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December 10, 2020

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

Autoreactive B cells mediate autoimmune pathology, however precisely how stays unknown. A trademark of rheumatoid arthritis (RA), a standard autoimmune illness, is the presence of disease-specific anticitrullinated protein antibodies (ACPAs). Right here, we confirmed that ACPA-positive B cells in sufferers with RA strongly expressed T cell-stimulating ligands, produced considerable proinflammatory cytokines, and have been proliferative whereas escaping inhibitory alerts. This activated state was discovered at […]