nfkb-p65

Transcription issue GLIS3: Crucial roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes

GLI-Comparable 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc finger transcription elements that capabilities as an activator or repressor of gene expression. Examine of GLIS3-deficiency in mice and people revealed that GLIS3 performs a essential function within the regulation of a number of organic processes and is implicated within the growth of assorted illnesses, together with hypothyroidism and diabetes.

This was supported by genome-wide affiliation research that recognized important associations of frequent variants in GLIS3 with elevated threat of those pathologies. To acquire insights into the causal mechanisms underlying these illnesses, it’s crucial to know the mechanisms by which this protein regulates the event of those pathologies. Current research of genes regulated by GLIS3 led to the identification of numerous goal genes and have supplied essential molecular insights by which GLIS3 controls mobile processes.

MEF-2C Polyclonal Antibody

These research revealed that GLIS3 is important for thyroid hormone biosynthesis and recognized a essential operate for GLIS3 within the technology of pancreatic β cells and insulin gene transcription. These observations raised the chance that the GLIS3 signaling pathway may present a possible therapeutic goal within the administration of diabetes, hypothyroidism, and different illnesses.

nfkb-p65

nfkb-p65

To develop such methods, will probably be essential to know the upstream signaling pathways that regulate the exercise, expression and performance of GLIS3. Right here, we assessment the current progress on the molecular mechanisms by which GLIS3 controls key capabilities in thyroid follicular and pancreatic β cells and the way this causally pertains to the event of hypothyroidism and diabetes.

 

 

Platelet microparticles-derived miR-25-3p promotes the hepatocyte proliferation and cell autophagy by way of decreasing Bcell translocation gene 2

 

  • Platelets are vital regulators of liver regeneration, however the mechanisms are nonetheless not totally understood. Platelets have been proven to include all kinds of microRNAs (miRNAs) and play an essential function in lots of illnesses. Nevertheless, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate the hepatocyte proliferation just isn’t very clear. On this research, now we have efficiently remoted and recognized PMPs.
  • We additionally discovered that PMPs, which may very well be nicely built-in into the HHL-5 cells, might upregulate the extent of miR-25-3p in HHL-5 cells. In the meantime, we discovered that PMPs-derived miR-25-3p promoted HHL-5 cells proliferation by accelerating cells into the S part, and enhanced the autophagy by growing the LC3II expression and decreasing the P62 expression.
  • Then, we proved that the miR-25-3p might goal the B-cell translocation gene 2 (BTG2) and downregulate the expression ranges of the BTG2 gene in HHL-5 cells. As well as, the overexpression of BTG2 considerably inhibited the proliferation and autophagy talents of HHL-5 cells, whereas cotransfected miR-25-3p mimics or PMPs might partially rescue HHL-5 cells proliferation and autophagy.
  • Moreover, we proved that PMPs accelerated hepatocyte proliferation by regulating autophagy pathways. Subsequently, PMPs-derived miR-25-3p promoted HHL-5 cell proliferation and autophagy by concentrating on BTG2, which can be a brand new therapeutic methodology for liver regeneration.

SNL Feeder Cells

MBS169018-1Vial 1Vial
EUR 850

SNL Feeder Cells

MBS169018-5x1Vial 5x1Vial
EUR 3575

Mouse Embryonic Fibroblast Feeder Cells

T2001 10^6 cells/1.0 ml
EUR 90

Zebrafish Testicular Feeder Cells (ZtA6-1)

T2600 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-2)

T2601 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-3)

T2602 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-4)

T2603 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-5)

T2604 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-6)

T2605 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-7)

T2606 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-8)

T2607 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-9)

T2608 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-10)

T2609 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-11)

T2610 1x10^6 cells/ml Ask for price

Zebrafish Testicular Feeder Cells (ZtA6-12)

T2611 1x10^6 cells/ml Ask for price

Human Dermal Fibroblasts-fetal Feeder Cells

T2002 10^6 cells/1.0 ml
EUR 200

Bone Marrow Non-Irradiated Stromal Cells (Feeder Cells), 5 million cells

LO2M-302 each
EUR 1501.14

Immortalized Mouse Embryonic Fibroblast Feeder Cells

T2003 10^6 cells/1.0 ml
EUR 130

Immortalized Human Dermal Fibroblast-fetal Feeder Cells

T2004 10^6 cells/1.0 ml
EUR 230

MITC Inactivated Rat Embryonic Fibroblast (REF) Feeder Cells

T2017 2 x 10^6 cells/1.0 ml
EUR 50

MITC Treated Immortalized Mouse Embryonic Fibroblast Feeder Cells

T2009 10^6 cells/1.0 ml
EUR 35

Mouse Embryonic Blasticidin and Zeocin-resistant (MMMbz) Immortalized Feeder Cells

T2028 10^6 cells/1.0 ml
EUR 560

Mouse Feeder DR4

TBS8013 1 mL
EUR 190

ALF12 Feeder AI AIDC

195774 Pack of 1 Piece(s)
EUR 4483.5
Description: Description Dutch: ALF12-labelfeeder; Description French: Distributeur d’étiquettes ALF12

ALF14-25 Feeder AI AIDC

240696 Pack of 1 Piece(s)
EUR 4798.5
Description: Description Dutch: ALF14-25 Labelfeeder met microschakelaar die detecteert of het deksel geopend is; Description French: Distributeur d’étiquettes ALF14-25 avec microrupteur de détection d’ouverture du couvercle

Falcon Hts Feeder Tray Plate And Lid For Multiwell Insert System - PK5

351186 PK5
EUR 170.1

FALCON® 96 WELL FEEDER POLYSTYRENE TRAY, WITH LID, STERILE, 5/PACK, 5/CASE

353924 5/pk
EUR 144
Description: Permeable Support - DL; HTS Transwells - DL

Falcon Hts 96 Well 1um Multiwell Multipack Insert System With Plate Feeder Tray - PK5

351131 PK5
EUR 3053.7

Falcon Hts 24 Well 8um Multiwell Insert System With Plate Feeder Tray And Dish - EACH

351157 EACH
EUR 324

Falcon Hts 24 Well 1um Multiwell Multipack Insert System With Plate Feeder Tray And Dish - PK5

351181 PK5
EUR 787.05

Falcon Hts 24 Well 3um Multiwell Mulltipack Insert System With Plate Feeder Tray And Dish - PK5

351156 PK5
EUR 1383.75

FALCON® 96 WELL MULTIWELL INSERT SYSTEM WITH 1.0 ΜM PORE TRANSLUCENT PET MEMBRANE, WITH FEEDER TRAY AND LID, 1/CASE

351130 1/pk
EUR 412.8
Description: Permeable Support - DL; HTS Transwells - DL

Immortalized MEF Psen1/2-/- Cells

T0819 1x10^6 cells / 1.0 ml
EUR 3950

DR4 MEF, P2, untreated, 1 vial of 1´106 cells

ASF-1001 1 vial of 1 x 10^6 cells
EUR 131.45
Description: 6 month

CF1 MEF, P2, untreated, 1 vial of 1^106 cells

ASF-1201 1 vial of 1 x 10^6 cells
EUR 95.92
Description: 6 month

DR4 MEF, P2, untreated, 3 vials of 1^106 cells

ASF-1002 3 vial of 1 x 10^6 cells
EUR 254.68
Description: 6 month

DR4 MEF, P3, irradiated, 1 vial of 4^106 cells

ASF-1013 1 vial of 4 x 10^6 cells
EUR 107.63
Description: 6 month

DR4 MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1015 1 vial of 2 x 10^6 cells
EUR 87.97
Description: 6 month

DR4 MEF, P3, irradiated, 5 vial of 2^106 cells

ASF-1016 5 vials of 2 x 10^6 cells
EUR 189.28
Description: 6 month

CF1 MEF, P2, untreated, 3 vials of 1^106 cells

ASF-1202 3 vials of 1 x 10^6 cells
EUR 161.3
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 4^106 cells

ASF-1213 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1215 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 1^106 cells

ASF-1217 1 vial of 1 x 10^6 cells
EUR 69.07
Description: 6 month

DR4 MEF, P3, irradiated, 5 vials of 4^106 cells

ASF-1014 5 vials of 4 x 10^6 cells
EUR 278.48
Description: 6 month

CF1 MEF, P3, irradiated, 5 vials of 4^106 cells

ASF-1214 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

CF1 MEF, P3, irradiated, 8 vials of 2^106 cells

ASF-1216 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

Immortalized Mouse Embryonic Fibroblast MEF Cells (C57B6 Mice) - SV40

T9275 1x10^6 cells / 1.0 ml
EUR 450

Neo resistant MEF, P2, untreated, 1 vial of 1^106 cells

ASF-1101 1 vial of 1 x 10^6 cells
EUR 95.92
Description: 6 month

Neo resistant MEF, P2, untreated, 3 vials of 1^106 cells

ASF-1102 3 vials of 1 x 10^6 cells
EUR 161.3
Description: 6 month

Neo resistant MEF, P3, irradiated, 1 vial of 4^106 cells

ASF-1113 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

Neo resistant MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1115 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

Neo resistant MEF, P3, irradiated, 5 vials of 4^106 cells

ASF-1114 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

Neo resistant MEF, P3, irradiated, 8 vials of 2^106 cells

ASF-1116 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1023 1 vial of 4 x 10^6 cells
EUR 107.63
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1025 1 vial of 2 x 10^6 cells
EUR 87.97
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 5 vial of 2^106 cells

ASF-1026 5 vials of 2 x 10^6 cells
EUR 189.28
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1223 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1225 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1024 5 vials of 4 x 10^6 cells
EUR 278.48
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1224 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells

ASF-1226 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

Immortalized Mouse Embryonic Fibroblast MEF Cells (Balb/c Nctr Mice) - SV40

T9274 1x10^6 cells / 1.0 ml
EUR 450

Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1123 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1125 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1124 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells

ASF-1126 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

CHO|ONE Feed 2, Supplement for CHO cells, without L-Glutamine - 10 ml

CACHOF2-10ML each
EUR 28.37

CHO|ONE Feed 2, Supplement for CHO cells, without L-Glutamine - 50 ml

CACHOF2-50ML each
EUR 92.89

CHO|ONE Feed 1, Supplement for CHO cells, without Insulin, without L-Glutamine - 100 ml

CACHOF1-100ML each
EUR 43.72

CHO|ONE Feed 1, Supplement for CHO cells, without Insulin, without L-Glutamine - 500 ml

CACHOF1-500ML each
EUR 180.16

PTEN Stable MEF Cell Line

T6180 1x10^6 cells / 1.0 ml
EUR 3950

PTEN Stable Knockout MEF Cell Line

T6179 1x10^6 cells / 1.0 ml
EUR 3950

APPL1 Stable Knockout MEF Cell Line

T6158 1x10^6 cells / 1.0 ml
EUR 3950

APPL1 Stable Wildtype MEF Cell Line

T6159 1x10^6 cells / 1.0 ml
EUR 3950

MEF-iPSC

T2019 10^6 cells/vial
EUR 390

Dendritic Cells/B Cells Antibody

abx412775-02mg 0.2 mg
EUR 678

Human Fetal Liver Cells CD34+ Cells

ABC-TC3421 1 vial Ask for price
Description: First, fetal liver is homogenized. Then, a density separation gradient media (1.077g/ml density) is used to isolate the Mononuclear Cells. Next, a direct immunomagnetic CD34 MicroBead labeling system is used to positively isolate FL-CD34+ cells.

Human Fetal Liver Cells CD133+ Cells

ABC-TC3420 1 vial Ask for price
Description: Fetal liver is homogenized, and then a density separation gradient media (1.077 g/ml density) is used to isolate the mononuclear cells. Next, a direct immunomagnetic CD133 MicroBead labeling system is used to positively select FL-CD133+ cells. The majority of CD133+ cells express the CD34 cell marker.

MEF-2 Antibody

B0019-100ul 100μl
EUR 217
Description: MEF-2 Rabbit Polyclonal Antibody

MEF-2 Antibody

B0019-50ul 50μl
EUR 143.5
Description: MEF-2 Rabbit Polyclonal Antibody

MEF-2 Antibody

B7144-100ul 100μl
EUR 217
Description: MEF-2 Rabbit Polyclonal Antibody

MEF-2 Antibody

B7144-50ul 50μl
EUR 143.5
Description: MEF-2 Rabbit Polyclonal Antibody

MEF-2 Antibody

B7145-100ul 100μl
EUR 217
Description: MEF-2 Rabbit Polyclonal Antibody

MEF-2 Antibody

B7145-50ul 50μl
EUR 143.5
Description: MEF-2 Rabbit Polyclonal Antibody

MEF-2D Antibody

B0510-100ul 100μl
EUR 217
Description: MEF-2D Rabbit Polyclonal Antibody

MEF-2D Antibody

B0510-50ul 50μl
EUR 143.5
Description: MEF-2D Rabbit Polyclonal Antibody

MEF-2C Antibody

B8370-100ul 100μl
EUR 217
Description: MEF-2C Rabbit Polyclonal Antibody

MEF-2C Antibody

B8370-50ul 50μl
EUR 143.5
Description: MEF-2C Rabbit Polyclonal Antibody

MEF-2B Antibody

C10843-100ul 100μl
EUR 217
Description: MEF-2B Rabbit Polyclonal Antibody

MEF-2B Antibody

C10843-50ul 50μl
EUR 143.5
Description: MEF-2B Rabbit Polyclonal Antibody

Mesenchymal Stem Cells cells, cryo amp

LOPT-2501 each
EUR 2046.79

C3−/−C3Δ28 Stable Expressing MEF Cell Line

T6429 1x10^6 cells / 1.0 ml
EUR 3950

CD7 (T cells and NK cells), Antibody

GWB-20A27F 0.2 mg Ask for price

C3−/−C3Δ28C163A Stable Expressing MEF Cell Line

T6430 1x10^6 cells / 1.0 ml
EUR 3950

Human Blood CD14+ Cells, 10 million cells

ABC-TC3110 1 vial Ask for price
Description: Monocytes are found in the circulating peripheral blood where they make up 10-20% of the mononuclear cells. They play an important role in host defense, both as circulating monocytes and by leaving the circulation and differentiating to tissue macrophage

Human Blood CD14+ Cells, 20 million cells

ABC-TC3111 1 vial Ask for price
Description: Monocytes are found in the circulating peripheral blood where they make up 10-20% of the mononuclear cells. They play an important role in host defense, both as circulating monocytes and by leaving the circulation and differentiating to tissue macrophage

Human Blood CD14+ Cells, 40 million cells

ABC-TC3112 1 vial Ask for price
Description: Monocytes are found in the circulating peripheral blood where they make up 10-20% of the mononuclear cells. They play an important role in host defense, both as circulating monocytes and by leaving the circulation and differentiating to tissue macrophage

 

IL-10-producing B cells play essential function within the pathogenesis of recurrent being pregnant loss

 

Interleukin (IL)-10-producing B cells are lately identified for his or her regulatory operate in a number of issues. Nevertheless, the attainable function of those cells stays unclear in recurrent being pregnant loss (RPL) pathogenesis. Complete B cells from 24 RPL sufferers with mobile immune abnormalities, in addition to that of 25 regular pregnant girls had been cultured and stimulated by Toll Like Receptor (TLR) agonists (CpG oligodeoxynucleotides (ODN) and imiquimod).

TW,96WL,HTS,FEEDER RESERVIOR W/LID,S,BK,10/10

Then, the frequency of IL-10+ CD19+ B cells was came upon utilizing circulate cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the degrees of IL-10 in supernatant medium and serum of stimulated B cells, in addition to these of a number of serum autoantibodies. Actual-Time PCR methodology was carried out for figuring out the IL-10 expression stage and particular genes transcripts. RPL sufferers indicated a decrease proportion of IL-10+ CD19+ B cells, and diminished ranges of IL-10 in each serum and supernatant of the tradition medium of the stimulated B cells.

EZSolution? Puromycin Dihydrochloride

In accordance with the outcomes, whole IgG ranges was better in serum of RPL sufferers compared with wholesome pregnant girls. Equally, the proportion of those cells was negatively correlated with serum whole IgG ranges and the variety of miscarriages. The expression ranges of the mRNA of programmed death-ligand 1 (PD-L1) and IL-10 had been decrease in RPL sufferers, whereas these of x binding protein 1 (XBP-1), interferon regulatory issue 4 (IRF4), and B lymphocyte-induced maturation protein 1 (BLIMP1) had been considerably elevated.

These observations indicated that the discount within the inhabitants of peripheral blood IL-10-synthesizing B cells could immediate RPL pathogenesis, suggesting suppressive results of those cells on autoantibody manufacturing and profitable being pregnant outcomes.

 

NuMA (Nuclear Mitotic Apparatus Protein, Centrophilin Stabilizes Mitotic Spindle in Mitotic Cells, NuMA Protein, NUMA1, SP-H Antigen, Structural Nuclear Protein)

MBS620393-5x01mL 5x0.1mL
EUR 2910

BUB3, CT (Mitotic Checkpoint Protein BUB3)

MBS645567-005mg 0.05mg
EUR 745

BUB3, CT (Mitotic Checkpoint Protein BUB3)

MBS645567-5x005mg 5x0.05mg
EUR 3195

p27Kip1 (Mitotic Inhibitor/Suppressor Protein)

MBS4380777-05mL 0.5mL
EUR 405

p27Kip1 (Mitotic Inhibitor/Suppressor Protein)

MBS4380777-5x05mL 5x0.5mL
EUR 1725

p27Kip1 (Mitotic Inhibitor/Suppressor Protein)

MBS4380778-05mL 0.5mL
EUR 405

p27Kip1 (Mitotic Inhibitor/Suppressor Protein)

MBS4380778-5x05mL 5x0.5mL
EUR 1725

Early Mitotic Inhibitor 2 (EMI2) Antibody

abx432213-200ul 200 ul
EUR 460.8

Early Mitotic Inhibitor 2 (EMI2) Antibody

abx432213-100g 100 µg
EUR 387.5

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181)

MBS6005928-02mL 0.2(mL
EUR 695

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181)

MBS6005928-5x02mL 5x0.2mL
EUR 2975

EMI1 Antibody (Early Mitotic Inhibitor-1)

V7090-100UG 100 ug
EUR 424.15
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V7090-20UG 20 ug
EUR 186.15
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V7090IHC-7ML 7 ml
EUR 424.15
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V7090SAF-100UG 100 ug
EUR 424.15
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527-100UG 100 ug
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527-20UG 20 ug
EUR 153.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527IHC-7ML 7 ml
EUR 424.15
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527SAF-100UG 100 ug
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (AP)

MBS6317901-02mL 0.2mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (AP)

MBS6317901-5x02mL 5x0.2mL
EUR 4250

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (APC)

MBS6317902-02mL 0.2mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (APC)

MBS6317902-5x02mL 5x0.2mL
EUR 4250

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (FITC)

MBS6317904-02mL 0.2mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (FITC)

MBS6317904-5x02mL 5x0.2mL
EUR 4250

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (PE)

MBS6317911-02mL 0.2mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (PE)

MBS6317911-5x02mL 5x0.2mL
EUR 4250

Mitotic Checkpoint Protein BUB3 (BUB3) Protein

20-abx260818
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  • 1 mg
  • 20 ug
  • 5 ug

Mitotic Checkpoint Protein BUB3 (BUB3) Protein

abx260818-10g 10 µg
EUR 325

Mitotic Checkpoint Protein BUB3 (BUB3) Protein

abx260818-2g 2 µg
EUR 225

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx111279
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  • 150 ul
  • 50 ul

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx119087
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx122177-100ug 100 ug
EUR 469.2

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx005015
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Mitotic Checkpoint Protein BUB3 (Bub3) Antibody

abx037779-100ug 100 ug
EUR 469.2

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx008443
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  • 100 ul
  • 200 ul
  • 30 ul

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx213427
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  • 100 ul
  • 50 ul

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx230988-100ug 100 ug
EUR 610.8

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx329635
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  • 100 ug
  • 50 ug

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx317981
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx119087-100l 100 µl
EUR 312.5

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx119087-20l 20 µl
EUR 43.75

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx119087-50l 50 µl
EUR 237.5

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx213427-100g 100 µg
EUR 250

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx122177-100l 100 µl Ask for price

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx122177-20l 20 µl
EUR 337.5

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx122177-50l 50 µl Ask for price

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx111279-100l 100 µl
EUR 612.5

Mitotic Checkpoint Protein BUB3 (Bub3) Antibody

abx037779-96tests 96 tests
EUR 337.5

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx137644-01mg 0.1 mg
EUR 225

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx230988-100g 100 µg
EUR 350

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx329635-100g 100 µg Ask for price

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx329635-20g 20 µg
EUR 187.5

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx329635-50g 50 µg
EUR 250

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx317981-100g 100 µg
EUR 362.5

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx317981-20g 20 µg
EUR 162.5

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx317981-50g 50 µg
EUR 250

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx005015-100l 100 µl
EUR 400

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx005015-20l 20 µl
EUR 175

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx005015-50l 50 µl
EUR 275

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (Biotin)

MBS6317903-02mL 0.2mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (Biotin)

MBS6317903-5x02mL 5x0.2mL
EUR 4250

MAD1L1 (Mitotic Arrest Deficient 1-Like 1)

MBS611039-01mg 0.1mg
EUR 905

MAD1L1 (Mitotic Arrest Deficient 1-Like 1)

MBS611039-5x01mg 5x0.1mg
EUR 3925

Nuclear Mitotic Apparatus Protein (NUMA) Antibody

20-abx133724
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  • 100 ul
  • 200 ul
  • 30 ul

Nuclear Mitotic Apparatus Protein (NuMA) Antibody

abx235912-100ug 100 ug
EUR 577.2

Nuclear Mitotic Apparatus Protein (NuMA) Antibody

abx235912-100g 100 µg
EUR 350

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 405)

MBS6317906-01mL 0.1mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 405)

MBS6317906-5x01mL 5x0.1mL
EUR 4250

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 490)

MBS6317907-01mL 0.1mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 490)

MBS6317907-5x01mL 5x0.1mL
EUR 4250

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 550)

MBS6317908-01mL 0.1mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 550)

MBS6317908-5x01mL 5x0.1mL
EUR 4250

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 650)

MBS6317909-01mL 0.1mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 650)

MBS6317909-5x01mL 5x0.1mL
EUR 4250

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 750)

MBS6317910-01mL 0.1mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (MaxLight 750)

MBS6317910-5x01mL 5x0.1mL
EUR 4250

Mitotic spindle assembly checkpoint protein MAD1

AP89429 1mg
EUR 2640

Mitotic spindle assembly checkpoint protein MAD1

AP85093 1mg
EUR 2640

Human G2/mitotic-specific cyclin-B1 (CCNB1)

1-CSB-YP004806HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human G2/mitotic-specific cyclin-B1(CCNB1) expressed in Yeast

Human G2/mitotic-specific cyclin-B1 (CCNB1)

1-CSB-BP004806HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
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  • 50ug
Description: Recombinant Human G2/mitotic-specific cyclin-B1(CCNB1) expressed in Baculovirus

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (Azide free) (HRP)

MBS6317905-02mL 0.2mL
EUR 980

MAD1L1, NT (MAD1L1, MAD1, TXBP181, Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Tax-binding protein 181) (Azide free) (HRP)

MBS6317905-5x02mL 5x0.2mL
EUR 4250

MAD2 Mitotic Arrest Deficient-Like 1 Protein

20-abx263455
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  • 1 µg
  • 50 ug
  • 5 ug

MAD2 Mitotic Arrest Deficient-Like 1 Protein

abx263455-10mg 10 mg
EUR 1600

MAD2 Mitotic Arrest Deficient-Like 1 Protein

abx263455-2mg 2 mg
EUR 225

MAD2 Mitotic Arrest Deficient-Like 1 Protein

abx263455-5mg 5 mg
EUR 325