nfkb-p65

Transcription issue GLIS3: Crucial roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes

GLI-Comparable 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc finger transcription elements that capabilities as an activator or repressor of gene expression. Examine of GLIS3-deficiency in mice and people revealed that GLIS3 performs a essential function within the regulation of a number of organic processes and is implicated within the growth of assorted illnesses, together with hypothyroidism and diabetes.

This was supported by genome-wide affiliation research that recognized important associations of frequent variants in GLIS3 with elevated threat of those pathologies. To acquire insights into the causal mechanisms underlying these illnesses, it’s crucial to know the mechanisms by which this protein regulates the event of those pathologies. Current research of genes regulated by GLIS3 led to the identification of numerous goal genes and have supplied essential molecular insights by which GLIS3 controls mobile processes.

MEF-2C Polyclonal Antibody

These research revealed that GLIS3 is important for thyroid hormone biosynthesis and recognized a essential operate for GLIS3 within the technology of pancreatic β cells and insulin gene transcription. These observations raised the chance that the GLIS3 signaling pathway may present a possible therapeutic goal within the administration of diabetes, hypothyroidism, and different illnesses.

nfkb-p65

nfkb-p65

To develop such methods, will probably be essential to know the upstream signaling pathways that regulate the exercise, expression and performance of GLIS3. Right here, we assessment the current progress on the molecular mechanisms by which GLIS3 controls key capabilities in thyroid follicular and pancreatic β cells and the way this causally pertains to the event of hypothyroidism and diabetes.

 

 

Platelet microparticles-derived miR-25-3p promotes the hepatocyte proliferation and cell autophagy by way of decreasing Bcell translocation gene 2

 

  • Platelets are vital regulators of liver regeneration, however the mechanisms are nonetheless not totally understood. Platelets have been proven to include all kinds of microRNAs (miRNAs) and play an essential function in lots of illnesses. Nevertheless, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate the hepatocyte proliferation just isn’t very clear. On this research, now we have efficiently remoted and recognized PMPs.
  • We additionally discovered that PMPs, which may very well be nicely built-in into the HHL-5 cells, might upregulate the extent of miR-25-3p in HHL-5 cells. In the meantime, we discovered that PMPs-derived miR-25-3p promoted HHL-5 cells proliferation by accelerating cells into the S part, and enhanced the autophagy by growing the LC3II expression and decreasing the P62 expression.
  • Then, we proved that the miR-25-3p might goal the B-cell translocation gene 2 (BTG2) and downregulate the expression ranges of the BTG2 gene in HHL-5 cells. As well as, the overexpression of BTG2 considerably inhibited the proliferation and autophagy talents of HHL-5 cells, whereas cotransfected miR-25-3p mimics or PMPs might partially rescue HHL-5 cells proliferation and autophagy.
  • Moreover, we proved that PMPs accelerated hepatocyte proliferation by regulating autophagy pathways. Subsequently, PMPs-derived miR-25-3p promoted HHL-5 cell proliferation and autophagy by concentrating on BTG2, which can be a brand new therapeutic methodology for liver regeneration.

Falcon Hts 24 Well 3um Multiwell Mulltipack Insert System With Plate Feeder Tray And Dish

351156 PK5
EUR 1230

Falcon Hts 24 Well 1um Multiwell Multipack Insert System With Plate Feeder Tray And Dish

351181 PK5
EUR 699.6

FALCON® 96 WELL MULTIWELL INSERT SYSTEM WITH 1.0 ΜM PORE TRANSLUCENT PET MEMBRANE, WITH FEEDER TRAY AND LID, 1/CASE

351130 1/pk
EUR 412.8
Description: Permeable Support - DL; HTS Transwells - DL

DR4 MEF, P2, untreated, 1 vial of 1´106 cells

ASF-1001 1 vial of 1 x 10^6 cells
EUR 131.45
Description: 6 month

CF1 MEF, P2, untreated, 1 vial of 1^106 cells

ASF-1201 1 vial of 1 x 10^6 cells
EUR 95.92
Description: 6 month

DR4 MEF, P2, untreated, 3 vials of 1^106 cells

ASF-1002 3 vial of 1 x 10^6 cells
EUR 254.68
Description: 6 month

DR4 MEF, P3, irradiated, 1 vial of 4^106 cells

ASF-1013 1 vial of 4 x 10^6 cells
EUR 107.63
Description: 6 month

DR4 MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1015 1 vial of 2 x 10^6 cells
EUR 87.97
Description: 6 month

DR4 MEF, P3, irradiated, 5 vial of 2^106 cells

ASF-1016 5 vials of 2 x 10^6 cells
EUR 189.28
Description: 6 month

CF1 MEF, P2, untreated, 3 vials of 1^106 cells

ASF-1202 3 vials of 1 x 10^6 cells
EUR 161.3
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 4^106 cells

ASF-1213 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1215 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 1^106 cells

ASF-1217 1 vial of 1 x 10^6 cells
EUR 69.07
Description: 6 month

DR4 MEF, P3, irradiated, 5 vials of 4^106 cells

ASF-1014 5 vials of 4 x 10^6 cells
EUR 278.48
Description: 6 month

CF1 MEF, P3, irradiated, 5 vials of 4^106 cells

ASF-1214 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

CF1 MEF, P3, irradiated, 8 vials of 2^106 cells

ASF-1216 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

Neo resistant MEF, P2, untreated, 1 vial of 1^106 cells

ASF-1101 1 vial of 1 x 10^6 cells
EUR 95.92
Description: 6 month

Neo resistant MEF, P2, untreated, 3 vials of 1^106 cells

ASF-1102 3 vials of 1 x 10^6 cells
EUR 161.3
Description: 6 month

Neo resistant MEF, P3, irradiated, 1 vial of 4^106 cells

ASF-1113 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

Neo resistant MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1115 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

Neo resistant MEF, P3, irradiated, 5 vials of 4^106 cells

ASF-1114 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

Neo resistant MEF, P3, irradiated, 8 vials of 2^106 cells

ASF-1116 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1023 1 vial of 4 x 10^6 cells
EUR 107.63
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1025 1 vial of 2 x 10^6 cells
EUR 87.97
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 5 vial of 2^106 cells

ASF-1026 5 vials of 2 x 10^6 cells
EUR 189.28
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1223 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1225 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1024 5 vials of 4 x 10^6 cells
EUR 278.48
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1224 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells

ASF-1226 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1123 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1125 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1124 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells

ASF-1126 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

Dendritic Cells/B Cells Antibody

abx412775-02mg 0.2 mg
EUR 678

MEF (CF-1)

P0011016 One Frozen vial
EUR 145

anti-Elf4/MEF

YF-PA23641 50 ul
EUR 400.8
Description: Mouse polyclonal to Elf4/MEF

anti-Elf4/MEF

YF-PA11546 100 ug
EUR 483.6
Description: Rabbit polyclonal to Elf4/MEF

5637 cells

C0002001 One Frozen vial
EUR 582

FO cells

C0003017 One Frozen vial
EUR 582

K1 cells

C0025003 One Frozen vial
EUR 792

RD cells

C0035001 One Frozen vial
EUR 546

A9 cells

P0011007 One Frozen vial
EUR 651.6

BJ cells

P0020005 One Frozen vial
EUR 546

ST cells

P0028002 One Frozen vial
EUR 651.6

RS4;11 cells

C0003012 One Frozen vial
EUR 546

REH cells

C0003031 One Frozen vial
EUR 582

4T1 cells

C0006004 One Frozen vial
EUR 546

T84 cells

C0009008 One Frozen vial
EUR 546

RKO cells

C0009012 One Frozen vial
EUR 546

H23 cells

C0016005 One Frozen vial
EUR 546

H69 cells

C0016065 One Frozen vial
EUR 546

H82 cells

C0016066 One Frozen vial
EUR 546

A10.7 cells

C0018006 One Frozen vial
EUR 792

C32 cells

C0020002 One Frozen vial
EUR 546

N87 cells

C0023002 One Frozen vial
EUR 546

AGS cells

C0023004 One Frozen vial
EUR 546

R2C cells

C0028001 One Frozen vial
EUR 651.6

Y79 cells

C0029001 One Frozen vial
EUR 546

NB3 cells

C0033003 One Frozen vial
EUR 792

STO cells

P0011006 One Frozen vial
EUR 546

TM3 cells

T0028002 One Frozen vial
EUR 546

MEF-2 Polyclonal Antibody

41129-100ul 100ul
EUR 302.4

MEF-2 Polyclonal Antibody

41129-50ul 50ul
EUR 224.4

MEF-2 Polyclonal Antibody

41130-100ul 100ul
EUR 302.4

MEF-2 Polyclonal Antibody

41130-50ul 50ul
EUR 224.4

MEF-2 Polyclonal Antibody

ABP51767-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2 Polyclonal Antibody

ABP51767-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2 Polyclonal Antibody

ABP51767-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2 Polyclonal Antibody

ABP55220-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody

ABP55220-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody

ABP55220-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody

ABP55221-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2 Polyclonal Antibody

ABP55221-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2 Polyclonal Antibody

ABP55221-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2 Polyclonal Antibody

ES6219-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 Polyclonal Antibody

ES6219-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 Polyclonal Antibody

ES6220-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2 Polyclonal Antibody

ES6220-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2 Polyclonal Antibody

ES2766-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2 Polyclonal Antibody

ES2766-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2 Polyclonal Antibody

E041129 100μg/100μl
EUR 255
Description: Available in various conjugation types.

MEF-2 Polyclonal Antibody

E041130 100μg/100μl
EUR 255
Description: Available in various conjugation types.

MEF-2 Polyclonal Antibody

E20-72698 100ug
EUR 225
Description: Available in various conjugation types.

MEF-2 Polyclonal Antibody

E20-72699 100ug
EUR 225
Description: Available in various conjugation types.

MEF-2 Polyclonal Antibody

E20-72700 100ug
EUR 225
Description: Available in various conjugation types.

MEF-2C Polyclonal Antibody

41131-100ul 100ul
EUR 302.4

MEF-2C Polyclonal Antibody

41131-50ul 50ul
EUR 224.4

MEF-2B Polyclonal Antibody

ABP51768-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

MEF-2B Polyclonal Antibody

ABP51768-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

MEF-2B Polyclonal Antibody

ABP51768-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

MEF-2C Polyclonal Antibody

ABP55224-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2C Polyclonal Antibody

ABP55224-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2C Polyclonal Antibody

ABP55224-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2D Polyclonal Antibody

ABP55227-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

MEF-2D Polyclonal Antibody

ABP55227-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

MEF-2D Polyclonal Antibody

ABP55227-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

 

IL-10-producing B cells play essential function within the pathogenesis of recurrent being pregnant loss

 

Interleukin (IL)-10-producing B cells are lately identified for his or her regulatory operate in a number of issues. Nevertheless, the attainable function of those cells stays unclear in recurrent being pregnant loss (RPL) pathogenesis. Complete B cells from 24 RPL sufferers with mobile immune abnormalities, in addition to that of 25 regular pregnant girls had been cultured and stimulated by Toll Like Receptor (TLR) agonists (CpG oligodeoxynucleotides (ODN) and imiquimod).

TW,96WL,HTS,FEEDER RESERVIOR W/LID,S,BK,10/10

Then, the frequency of IL-10+ CD19+ B cells was came upon utilizing circulate cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the degrees of IL-10 in supernatant medium and serum of stimulated B cells, in addition to these of a number of serum autoantibodies. Actual-Time PCR methodology was carried out for figuring out the IL-10 expression stage and particular genes transcripts. RPL sufferers indicated a decrease proportion of IL-10+ CD19+ B cells, and diminished ranges of IL-10 in each serum and supernatant of the tradition medium of the stimulated B cells.

EZSolution? Puromycin Dihydrochloride

In accordance with the outcomes, whole IgG ranges was better in serum of RPL sufferers compared with wholesome pregnant girls. Equally, the proportion of those cells was negatively correlated with serum whole IgG ranges and the variety of miscarriages. The expression ranges of the mRNA of programmed death-ligand 1 (PD-L1) and IL-10 had been decrease in RPL sufferers, whereas these of x binding protein 1 (XBP-1), interferon regulatory issue 4 (IRF4), and B lymphocyte-induced maturation protein 1 (BLIMP1) had been considerably elevated.

These observations indicated that the discount within the inhabitants of peripheral blood IL-10-synthesizing B cells could immediate RPL pathogenesis, suggesting suppressive results of those cells on autoantibody manufacturing and profitable being pregnant outcomes.

 

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527IHC-7ML 7 ml
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)

V2527SAF-100UG 100 ug
EUR 349.3
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

Mitotic Checkpoint Protein BUB3 (BUB3) Protein

20-abx260818
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx317981
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx230988-100ug 100 ug
EUR 610.8

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx213427
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

abx122177-100ug 100 ug
EUR 469.2

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx119087
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx111279
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Mitotic Checkpoint Protein BUB3 (Bub3) Antibody

abx037779-100ug 100 ug
EUR 469.2

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx329635
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx008443
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody

20-abx005015
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Nuclear Mitotic Apparatus Protein (NuMA) Antibody

abx235912-100ug 100 ug
EUR 577.2

Nuclear Mitotic Apparatus Protein (NUMA) Antibody

20-abx133724
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Human G2/mitotic-specific cyclin-B1 (CCNB1)

1-CSB-BP004806HU
  • EUR 913.20
  • EUR 367.20
  • EUR 2341.20
  • EUR 1231.20
  • EUR 1706.40
  • EUR 517.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human G2/mitotic-specific cyclin-B1(CCNB1) expressed in Baculovirus

Human G2/mitotic-specific cyclin-B1 (CCNB1)

1-CSB-YP004806HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human G2/mitotic-specific cyclin-B1(CCNB1) expressed in Yeast

MAD2 Mitotic Arrest Deficient-Like 1 Protein

20-abx263455
  • EUR 276.00
  • EUR 1930.80
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

G2/mitotic-Specific Cyclin-B3 (CCNB3) Antibody

20-abx149009
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx015791-100ul 100 ul
EUR 493.2

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx034750-400ul 400 ul
EUR 627.6

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx034750-80l 80 µl
EUR 343.2

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx034752-400ul 400 ul
EUR 627.6

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx034752-80l 80 µl
EUR 343.2

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx034753-400ul 400 ul
EUR 627.6

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx034753-80l 80 µl
EUR 343.2

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx034754-400ul 400 ul
EUR 627.6

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx034754-80l 80 µl
EUR 343.2

G2/mitotic-Specific Cyclin-B3 (CCNB3) Antibody

abx034757-400ul 400 ul
EUR 627.6

G2/mitotic-Specific Cyclin-B3 (CCNB3) Antibody

abx034757-80l 80 µl
EUR 343.2

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx037576-100ug 100 ug
EUR 469.2

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

20-abx001673
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

20-abx000700
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

G2/mitotic-Specific Cyclin-B1 (CCNB1) Antibody

abx011854-100ul 100 ul
EUR 493.2

Pig Mitotic spindle apparatus antibody ELISA kit

E07M0342-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Mitotic spindle apparatus antibody ELISA kit

E07M0342-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Mitotic spindle apparatus antibody ELISA kit

E07M0342-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Mitotic spindle apparatus antibody ELISA kit

E08M0342-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Mitotic spindle apparatus antibody ELISA kit

E08M0342-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Mitotic spindle apparatus antibody ELISA kit

E08M0342-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Mitotic spindle apparatus antibody ELISA kit

E02M0342-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Mitotic spindle apparatus antibody ELISA kit

E02M0342-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Mitotic spindle apparatus antibody ELISA kit

E02M0342-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody (HRP)

20-abx314065
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Goat Mitotic spindle apparatus antibody ELISA kit

E06M0342-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Mitotic spindle apparatus antibody ELISA kit

E06M0342-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Mitotic spindle apparatus antibody ELISA kit

E06M0342-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody (FITC)

20-abx314066
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse Mitotic spindle apparatus antibody ELISA kit

E03M0342-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Mitotic spindle apparatus antibody ELISA kit

E03M0342-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Mitotic spindle apparatus antibody ELISA kit

E03M0342-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Mitotic spindle apparatus antibody ELISA kit

E01M0342-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Mitotic spindle apparatus antibody ELISA kit

E01M0342-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Mitotic spindle apparatus antibody ELISA kit

E01M0342-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

20-abx173866
  • EUR 410.40
  • EUR 1028.40
  • EUR 526.80
  • EUR 184.80
  • EUR 309.60
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

20-abx324768
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

abx330645-100ul 100 ul
EUR 510

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

20-abx114180
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

20-abx128970
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

abx122642-100ug 100 ug
EUR 469.2

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

20-abx338488
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

20-abx000744
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antibody

abx145485-100ug 100 ug
EUR 469.2

Rabbit Mitotic spindle apparatus antibody ELISA kit

E04M0342-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Mitotic spindle apparatus antibody ELISA kit

E04M0342-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Mitotic spindle apparatus antibody ELISA kit

E04M0342-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Mitotic spindle apparatus antibody ELISA kit

E09M0342-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Mitotic spindle apparatus antibody ELISA kit

E09M0342-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Mitotic spindle apparatus antibody ELISA kit

E09M0342-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Mitotic spindle apparatus antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody (Biotin)

20-abx314067
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody

20-abx311940
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody

20-abx135805
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

abx234923-100ug 100 ug
EUR 577.2

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

abx234924-100ug 100 ug
EUR 661.2

Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody

abx234926-100ug 100 ug
EUR 577.2

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

20-abx211767
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

20-abx321660
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

abx331031-100ul 100 ul
EUR 510

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

20-abx113577
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody

20-abx113578
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

20-abx324057
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

20-abx320117
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

abx431997-200ul 200 ul
EUR 460.8

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

20-abx001424
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

20-abx015210
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody

abx145441-100ug 100 ug
EUR 469.2

Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody

abx145476-100ug 100 ug
EUR 469.2