Transcription issue GLIS3: Crucial roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes
GLI-Comparable 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc finger transcription elements that capabilities as an activator or repressor of gene expression. Examine of GLIS3-deficiency in mice and people revealed that GLIS3 performs a essential function within the regulation of a number of organic processes and is implicated within the growth of assorted illnesses, together with hypothyroidism and diabetes.
This was supported by genome-wide affiliation research that recognized important associations of frequent variants in GLIS3 with elevated threat of those pathologies. To acquire insights into the causal mechanisms underlying these illnesses, it’s crucial to know the mechanisms by which this protein regulates the event of those pathologies. Current research of genes regulated by GLIS3 led to the identification of numerous goal genes and have supplied essential molecular insights by which GLIS3 controls mobile processes.
MEF-2C Polyclonal Antibody
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These research revealed that GLIS3 is important for thyroid hormone biosynthesis and recognized a essential operate for GLIS3 within the technology of pancreatic β cells and insulin gene transcription. These observations raised the chance that the GLIS3 signaling pathway may present a possible therapeutic goal within the administration of diabetes, hypothyroidism, and different illnesses.

nfkb-p65
To develop such methods, will probably be essential to know the upstream signaling pathways that regulate the exercise, expression and performance of GLIS3. Right here, we assessment the current progress on the molecular mechanisms by which GLIS3 controls key capabilities in thyroid follicular and pancreatic β cells and the way this causally pertains to the event of hypothyroidism and diabetes.
Platelet microparticles-derived miR-25-3p promotes the hepatocyte proliferation and cell autophagy by way of decreasing B–cell translocation gene 2
- Platelets are vital regulators of liver regeneration, however the mechanisms are nonetheless not totally understood. Platelets have been proven to include all kinds of microRNAs (miRNAs) and play an essential function in lots of illnesses. Nevertheless, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate the hepatocyte proliferation just isn’t very clear. On this research, now we have efficiently remoted and recognized PMPs.
- We additionally discovered that PMPs, which may very well be nicely built-in into the HHL-5 cells, might upregulate the extent of miR-25-3p in HHL-5 cells. In the meantime, we discovered that PMPs-derived miR-25-3p promoted HHL-5 cells proliferation by accelerating cells into the S part, and enhanced the autophagy by growing the LC3II expression and decreasing the P62 expression.
- Then, we proved that the miR-25-3p might goal the B-cell translocation gene 2 (BTG2) and downregulate the expression ranges of the BTG2 gene in HHL-5 cells. As well as, the overexpression of BTG2 considerably inhibited the proliferation and autophagy talents of HHL-5 cells, whereas cotransfected miR-25-3p mimics or PMPs might partially rescue HHL-5 cells proliferation and autophagy.
- Moreover, we proved that PMPs accelerated hepatocyte proliferation by regulating autophagy pathways. Subsequently, PMPs-derived miR-25-3p promoted HHL-5 cell proliferation and autophagy by concentrating on BTG2, which can be a brand new therapeutic methodology for liver regeneration.
DR4 MEF, P3, irradiated, 1 vial of 2^106 cells |
ASF-1015 |
Applied StemCell |
1 vial of 2 x 10^6 cells |
EUR 87.97 |
Description: 6 month |
DR4 MEF, P3, irradiated, 5 vial of 2^106 cells |
ASF-1016 |
Applied StemCell |
5 vials of 2 x 10^6 cells |
EUR 189.28 |
Description: 6 month |
CF1 MEF, P2, untreated, 1 vial of 1^106 cells |
ASF-1201 |
Applied StemCell |
1 vial of 1 x 10^6 cells |
EUR 95.92 |
Description: 6 month |
CF1 MEF, P2, untreated, 3 vials of 1^106 cells |
ASF-1202 |
Applied StemCell |
3 vials of 1 x 10^6 cells |
EUR 161.3 |
Description: 6 month |
CF1 MEF, P3, irradiated, 1 vial of 4^106 cells |
ASF-1213 |
Applied StemCell |
1 vial of 4 x 10^6 cells |
EUR 78.14 |
Description: 6 month |
CF1 MEF, P3, irradiated, 5 vials of 4^106 cells |
ASF-1214 |
Applied StemCell |
5 vials of 4 x 10^6 cells |
EUR 145.43 |
Description: 6 month |
CF1 MEF, P3, irradiated, 1 vial of 2^106 cells |
ASF-1215 |
Applied StemCell |
1 vial of 2 x 10^6 cells |
EUR 73.99 |
Description: 6 month |
CF1 MEF, P3, irradiated, 8 vials of 2^106 cells |
ASF-1216 |
Applied StemCell |
8 vials of 2 x 10^6 cells |
EUR 161.69 |
Description: 6 month |
CF1 MEF, P3, irradiated, 1 vial of 1^106 cells |
ASF-1217 |
Applied StemCell |
1 vial of 1 x 10^6 cells |
EUR 69.07 |
Description: 6 month |
Neo resistant MEF, P2, untreated, 1 vial of 1^106 cells |
ASF-1101 |
Applied StemCell |
1 vial of 1 x 10^6 cells |
EUR 95.92 |
Description: 6 month |
Neo resistant MEF, P2, untreated, 3 vials of 1^106 cells |
ASF-1102 |
Applied StemCell |
3 vials of 1 x 10^6 cells |
EUR 161.3 |
Description: 6 month |
Neo resistant MEF, P3, irradiated, 1 vial of 4^106 cells |
ASF-1113 |
Applied StemCell |
1 vial of 4 x 10^6 cells |
EUR 78.14 |
Description: 6 month |
Neo resistant MEF, P3, irradiated, 5 vials of 4^106 cells |
ASF-1114 |
Applied StemCell |
5 vials of 4 x 10^6 cells |
EUR 145.43 |
Description: 6 month |
Neo resistant MEF, P3, irradiated, 1 vial of 2^106 cells |
ASF-1115 |
Applied StemCell |
1 vial of 2 x 10^6 cells |
EUR 73.99 |
Description: 6 month |
Neo resistant MEF, P3, irradiated, 8 vials of 2^106 cells |
ASF-1116 |
Applied StemCell |
8 vials of 2 x 10^6 cells |
EUR 161.69 |
Description: 6 month |
anti-Elf4/MEF |
YF-PA11546 |
Abfrontier |
100 ug |
EUR 483.6 |
Description: Rabbit polyclonal to Elf4/MEF |
anti-Elf4/MEF |
YF-PA23641 |
Abfrontier |
50 ul |
EUR 400.8 |
Description: Mouse polyclonal to Elf4/MEF |
DR4 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells |
ASF-1023 |
Applied StemCell |
1 vial of 4 x 10^6 cells |
EUR 107.63 |
Description: 6 month |
DR4 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells |
ASF-1024 |
Applied StemCell |
5 vials of 4 x 10^6 cells |
EUR 278.48 |
Description: 6 month |
DR4 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells |
ASF-1025 |
Applied StemCell |
1 vial of 2 x 10^6 cells |
EUR 87.97 |
Description: 6 month |
DR4 MEF, P3, mitomycin-C treated, 5 vial of 2^106 cells |
ASF-1026 |
Applied StemCell |
5 vials of 2 x 10^6 cells |
EUR 189.28 |
Description: 6 month |
CF1 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells |
ASF-1223 |
Applied StemCell |
1 vial of 4 x 10^6 cells |
EUR 78.14 |
Description: 6 month |
CF1 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells |
ASF-1224 |
Applied StemCell |
5 vials of 4 x 10^6 cells |
EUR 145.43 |
Description: 6 month |
CF1 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells |
ASF-1225 |
Applied StemCell |
1 vial of 2 x 10^6 cells |
EUR 73.99 |
Description: 6 month |
CF1 MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells |
ASF-1226 |
Applied StemCell |
8 vials of 2 x 10^6 cells |
EUR 161.69 |
Description: 6 month |
Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells |
ASF-1123 |
Applied StemCell |
1 vial of 4 x 10^6 cells |
EUR 78.14 |
Description: 6 month |
Neo resistant MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells |
ASF-1124 |
Applied StemCell |
5 vials of 4 x 10^6 cells |
EUR 145.43 |
Description: 6 month |
Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells |
ASF-1125 |
Applied StemCell |
1 vial of 2 x 10^6 cells |
EUR 73.99 |
Description: 6 month |
Neo resistant MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells |
ASF-1126 |
Applied StemCell |
8 vials of 2 x 10^6 cells |
EUR 161.69 |
Description: 6 month |
MEF-2 Polyclonal Antibody |
ES2766-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
MEF-2 Polyclonal Antibody |
ES2766-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
MEF-2B Polyclonal Antibody |
ES2767-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2B from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2B Polyclonal Antibody |
ES2767-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2B from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2 Polyclonal Antibody |
ES6219-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2 Polyclonal Antibody |
ES6219-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2 Polyclonal Antibody |
ES6220-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
MEF-2 Polyclonal Antibody |
ES6220-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
MEF-2C Polyclonal Antibody |
ES6223-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2C Polyclonal Antibody |
ES6223-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2C Polyclonal Antibody |
ES6224-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
MEF-2C Polyclonal Antibody |
ES6224-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
MEF-2D Polyclonal Antibody |
ES6226-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2D from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
MEF-2D Polyclonal Antibody |
ES6226-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2D from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
MEF-2 Polyclonal Antibody |
41129-100ul |
SAB |
100ul |
EUR 302.4 |
MEF-2 Polyclonal Antibody |
41129-50ul |
SAB |
50ul |
EUR 224.4 |
MEF-2 Polyclonal Antibody |
41130-100ul |
SAB |
100ul |
EUR 302.4 |
MEF-2 Polyclonal Antibody |
41130-50ul |
SAB |
50ul |
EUR 224.4 |
MEF-2C Polyclonal Antibody |
41131-100ul |
SAB |
100ul |
EUR 302.4 |
MEF-2C Polyclonal Antibody |
41131-50ul |
SAB |
50ul |
EUR 224.4 |
MEF-2 Polyclonal Antibody |
ABP55220-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312 |
MEF-2 Polyclonal Antibody |
ABP55220-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312 |
MEF-2 Polyclonal Antibody |
ABP55220-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312 |
MEF-2 Polyclonal Antibody |
ABP55221-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319 |
MEF-2 Polyclonal Antibody |
ABP55221-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319 |
MEF-2 Polyclonal Antibody |
ABP55221-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319 |
MEF-2C Polyclonal Antibody |
ABP55224-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396 |
MEF-2C Polyclonal Antibody |
ABP55224-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396 |
MEF-2C Polyclonal Antibody |
ABP55224-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396 |
MEF-2D Polyclonal Antibody |
ABP55227-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444 |
MEF-2D Polyclonal Antibody |
ABP55227-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444 |
MEF-2D Polyclonal Antibody |
ABP55227-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444 |
MEF-2 Polyclonal Antibody |
ABP51767-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408 |
MEF-2 Polyclonal Antibody |
ABP51767-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408 |
MEF-2 Polyclonal Antibody |
ABP51767-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408 |
MEF-2B Polyclonal Antibody |
ABP51768-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110 |
MEF-2B Polyclonal Antibody |
ABP51768-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110 |
MEF-2B Polyclonal Antibody |
ABP51768-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110 |
Anti-ELF4/Mef Antibody |
A03714 |
BosterBio |
100ul |
EUR 476.4 |
Description: Rabbit Polyclonal ELF4/Mef Antibody. Validated in WB and tested in Human. |
Anti-MEF-2 antibody |
STJ94063 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to MEF-2. |
Anti-MEF-2 antibody |
STJ94064 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to MEF-2. |
Anti-MEF-2 antibody |
STJ94065 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to MEF-2. |
Anti-MEF-2B antibody |
STJ94066 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to MEF-2B. |
Anti-MEF-2C antibody |
STJ94067 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to MEF-2C. |
Anti-MEF-2D antibody |
STJ94069 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to MEF-2D. |
Anti-Elf4/MEF (1E10) |
YF-MA12828 |
Abfrontier |
100 ug |
EUR 435.6 |
Description: Mouse monoclonal to Elf4/MEF |
Anti MEF Polyclonal Antibody |
KK053 |
Sceti |
each |
EUR 778.8 |
Description: The Anti MEF Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur. |
MEF-2 Polyclonal Conjugated Antibody |
C41129 |
SAB |
100ul |
EUR 476.4 |
MEF-2C Polyclonal Conjugated Antibody |
C41131 |
SAB |
100ul |
EUR 476.4 |
MEF-2 (phospho Ser408) Polyclonal Antibody |
ABP50510-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of MEF-2 phospho Ser408) from Human, Mouse, Rat. This MEF-2 phospho Ser408) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the phosphorylation site of S408 |
MEF-2 (phospho Ser408) Polyclonal Antibody |
ABP50510-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of MEF-2 phospho Ser408) from Human, Mouse, Rat. This MEF-2 phospho Ser408) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the phosphorylation site of S408 |
MEF-2 (phospho Ser408) Polyclonal Antibody |
ABP50510-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of MEF-2 phospho Ser408) from Human, Mouse, Rat. This MEF-2 phospho Ser408) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the phosphorylation site of S408 |
MEF-2 (phospho Thr319) Polyclonal Antibody |
ES1354-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr319) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2 (phospho Thr319) Polyclonal Antibody |
ES1354-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr319) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2 (phospho Ser408) Polyclonal Antibody |
ES1509-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Ser408) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
MEF-2 (phospho Ser408) Polyclonal Antibody |
ES1509-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Ser408) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
MEF-2 (phospho Thr312) Polyclonal Antibody |
ES6218-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr312) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA |
MEF-2 (phospho Thr312) Polyclonal Antibody |
ES6218-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr312) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA |
MEF-2C (phospho Ser396) Polyclonal Antibody |
ES6221-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser396) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2C (phospho Ser396) Polyclonal Antibody |
ES6221-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser396) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2C (phospho Ser387) Polyclonal Antibody |
ES6222-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser387) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
MEF-2C (phospho Ser387) Polyclonal Antibody |
ES6222-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser387) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
MEF-2D (phospho Ser444) Polyclonal Antibody |
ES6225-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MEF-2D (phospho Ser444) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2D (phospho Ser444) Polyclonal Antibody |
ES6225-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MEF-2D (phospho Ser444) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
MEF-2D (Phospho-Ser444) Polyclonal Antibody |
12205-100ul |
SAB |
100ul |
EUR 302.4 |
IL-10-producing B cells play essential function within the pathogenesis of recurrent being pregnant loss
Interleukin (IL)-10-producing B cells are lately identified for his or her regulatory operate in a number of issues. Nevertheless, the attainable function of those cells stays unclear in recurrent being pregnant loss (RPL) pathogenesis. Complete B cells from 24 RPL sufferers with mobile immune abnormalities, in addition to that of 25 regular pregnant girls had been cultured and stimulated by Toll Like Receptor (TLR) agonists (CpG oligodeoxynucleotides (ODN) and imiquimod).
TW,96WL,HTS,FEEDER RESERVIOR W/LID,S,BK,10/10
|
Then, the frequency of IL-10+ CD19+ B cells was came upon utilizing circulate cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the degrees of IL-10 in supernatant medium and serum of stimulated B cells, in addition to these of a number of serum autoantibodies. Actual-Time PCR methodology was carried out for figuring out the IL-10 expression stage and particular genes transcripts. RPL sufferers indicated a decrease proportion of IL-10+ CD19+ B cells, and diminished ranges of IL-10 in each serum and supernatant of the tradition medium of the stimulated B cells.
EZSolution? Puromycin Dihydrochloride
|
In accordance with the outcomes, whole IgG ranges was better in serum of RPL sufferers compared with wholesome pregnant girls. Equally, the proportion of those cells was negatively correlated with serum whole IgG ranges and the variety of miscarriages. The expression ranges of the mRNA of programmed death-ligand 1 (PD-L1) and IL-10 had been decrease in RPL sufferers, whereas these of x binding protein 1 (XBP-1), interferon regulatory issue 4 (IRF4), and B lymphocyte-induced maturation protein 1 (BLIMP1) had been considerably elevated.
These observations indicated that the discount within the inhabitants of peripheral blood IL-10-synthesizing B cells could immediate RPL pathogenesis, suggesting suppressive results of those cells on autoantibody manufacturing and profitable being pregnant outcomes.
Mitotic Checkpoint Protein BUB3 (BUB3) Antibody |
20-abx005015 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Mitotic Checkpoint Protein BUB3 (BUB3) Antibody |
20-abx008443 |
Abbexa |
-
EUR 360.00
-
EUR 526.80
-
EUR 226.80
|
|
|
Mitotic Checkpoint Protein BUB3 (Bub3) Antibody |
abx037779-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
Mitotic Checkpoint Protein BUB3 (BUB3) Antibody |
abx230988-100ug |
Abbexa |
100 ug |
EUR 610.8 |
|
Mitotic Checkpoint Protein BUB3 (BUB3) Protein |
20-abx260818 |
Abbexa |
-
EUR 4101.60
-
EUR 393.60
-
EUR 276.00
|
|
|
Mitotic Checkpoint Protein BUB3 (BUB3) Antibody |
20-abx329635 |
Abbexa |
|
|
|
Early Mitotic Inhibitor 2 (EMI2) Antibody |
abx432213-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
Mitotic Checkpoint Protein BUB3 (BUB3) Antibody |
20-abx317981 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Mitotic Checkpoint Protein BUB3 (BUB3) Antibody |
20-abx213427 |
Abbexa |
|
|
|
Nuclear Mitotic Apparatus Protein (NuMA) Antibody |
abx235912-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
EMI1 Antibody (Early Mitotic Inhibitor-1) |
V7090-100UG |
NSJ Bioreagents |
100 ug |
EUR 499 |
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. |
EMI1 Antibody (Early Mitotic Inhibitor-1) |
V7090-20UG |
NSJ Bioreagents |
20 ug |
EUR 219 |
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. |
EMI1 Antibody (Early Mitotic Inhibitor-1) |
V7090IHC-7ML |
NSJ Bioreagents |
7 ml |
EUR 499 |
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. |
EMI1 Antibody (Early Mitotic Inhibitor-1) |
V7090SAF-100UG |
NSJ Bioreagents |
100 ug |
EUR 499 |
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. |
EMI1 Antibody (Early Mitotic Inhibitor-1) |
V2527-100UG |
NSJ Bioreagents |
100 ug |
EUR 499 |
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. |
EMI1 Antibody (Early Mitotic Inhibitor-1) |
V2527-20UG |
NSJ Bioreagents |
20 ug |
EUR 219 |
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. |
EMI1 Antibody (Early Mitotic Inhibitor-1) |
V2527IHC-7ML |
NSJ Bioreagents |
7 ml |
EUR 499 |
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. |
EMI1 Antibody (Early Mitotic Inhibitor-1) |
V2527SAF-100UG |
NSJ Bioreagents |
100 ug |
EUR 499 |
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. |
5637 cells |
C0002001 |
Addexbio |
One Frozen vial |
EUR 582 |
MB49 cells |
C0002004 |
Addexbio |
One Frozen vial |
EUR 932.4 |
K562 cells |
C0003004 |
Addexbio |
One Frozen vial |
EUR 546 |
U937 cells |
C0003005 |
Addexbio |
One Frozen vial |
EUR 546 |
Raji cells |
C0003009 |
Addexbio |
One Frozen vial |
EUR 546 |
Daudi cells |
C0003010 |
Addexbio |
One Frozen vial |
EUR 546 |
RS4;11 cells |
C0003012 |
Addexbio |
One Frozen vial |
EUR 546 |
NAMALWA cells |
C0003013 |
Addexbio |
One Frozen vial |
EUR 546 |
BJAB cells |
C0003016 |
Addexbio |
One Frozen vial |
EUR 651.6 |
FO cells |
C0003017 |
Addexbio |
One Frozen vial |
EUR 582 |
MC116 cells |
C0003021 |
Addexbio |
One Frozen vial |
EUR 582 |
P3X63Ag8.653 cells |
C0003028 |
Addexbio |
One Frozen vial |
EUR 546 |
REH cells |
C0003031 |
Addexbio |
One Frozen vial |
EUR 582 |
Mino cells |
C0003033 |
Addexbio |
One Frozen vial |
EUR 582 |
U87MG cells |
C0005002 |
Addexbio |
One Frozen vial |
EUR 546 |
B103 cells |
C0005003 |
Addexbio |
One Frozen vial |
EUR 932.4 |
T47D cells |
C0006001 |
Addexbio |
One Frozen vial |
EUR 546 |
4T1 cells |
C0006004 |
Addexbio |
One Frozen vial |
EUR 546 |
HeLa cells |
C0008001 |
Addexbio |
One Frozen vial |
EUR 546 |
SiHa cells |
C0008002 |
Addexbio |
One Frozen vial |
EUR 546 |
C33A cells |
C0008003 |
Addexbio |
One Frozen vial |
EUR 546 |
CaSKi cells |
C0008004 |
Addexbio |
One Frozen vial |
EUR 546 |
SW480 cells |
C0009001 |
Addexbio |
One Frozen vial |
EUR 546 |
SW620 cells |
C0009002 |
Addexbio |
One Frozen vial |
EUR 546 |
T84 cells |
C0009008 |
Addexbio |
One Frozen vial |
EUR 546 |
HCT15 cells |
C0009010 |
Addexbio |
One Frozen vial |
EUR 546 |
LoVo cells |
C0009011 |
Addexbio |
One Frozen vial |
EUR 546 |
RKO cells |
C0009012 |
Addexbio |
One Frozen vial |
EUR 546 |
SW48 cells |
C0009014 |
Addexbio |
One Frozen vial |
EUR 546 |
SW1116 cells |
C0009019 |
Addexbio |
One Frozen vial |
EUR 546 |
H716 cells |
C0009022 |
Addexbio |
One Frozen vial |
EUR 651.6 |
OE33 cells |
C0013003 |
Addexbio |
One Frozen vial |
EUR 792 |
JROECL33 cells |
C0013004 |
Addexbio |
One Frozen vial |
EUR 792 |
Hep3B cells |
C0015001 |
Addexbio |
One Frozen vial |
EUR 546 |
HepG2 cells |
C0015002 |
Addexbio |
One Frozen vial |
EUR 546 |
Calu3 cells |
C0016001 |
Addexbio |
One Frozen vial |
EUR 546 |
A549 cells |
C0016002 |
Addexbio |
One Frozen vial |
EUR 546 |
H460 cells |
C0016003 |
Addexbio |
One Frozen vial |
EUR 546 |
A427 cells |
C0016004 |
Addexbio |
One Frozen vial |
EUR 546 |
H23 cells |
C0016005 |
Addexbio |
One Frozen vial |
EUR 546 |
H1703 cells |
C0016008 |
Addexbio |
One Frozen vial |
EUR 651.6 |
SW1573 cells |
C0016009 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H520 cells |
C0016010 |
Addexbio |
One Frozen vial |
EUR 546 |
H226 cells |
C0016011 |
Addexbio |
One Frozen vial |
EUR 546 |
HCC4006 cells |
C0016012 |
Addexbio |
One Frozen vial |
EUR 546 |
H1975 cells |
C0016013 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H1650 cells |
C0016015 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H358 cells |
C0016016 |
Addexbio |
One Frozen vial |
EUR 546 |
H2228 cells |
C0016017 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H2170 cells |
C0016018 |
Addexbio |
One Frozen vial |
EUR 546 |
H441 cells |
C0016019 |
Addexbio |
One Frozen vial |
EUR 546 |
H596 cells |
C0016020 |
Addexbio |
One Frozen vial |
EUR 546 |
H1581 cells |
C0016028 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H2444 cells |
C0016038 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H69AR cells |
C0016046 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H1373 cells |
C0016047 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H2122 cells |
C0016048 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H526 cells |
C0016052 |
Addexbio |
One Frozen vial |
EUR 546 |
H1299 cells |
C0016053 |
Addexbio |
One Frozen vial |
EUR 546 |
H446 cells |
C0016054 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H1770 cells |
C0016057 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H1184 cells |
C0016058 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H1694 cells |
C0016060 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H187 cells |
C0016061 |
Addexbio |
One Frozen vial |
EUR 546 |
H1963 cells |
C0016062 |
Addexbio |
One Frozen vial |
EUR 651.6 |
H209 cells |
C0016063 |
Addexbio |
One Frozen vial |
EUR 546 |
H69 cells |
C0016065 |
Addexbio |
One Frozen vial |
EUR 546 |
H82 cells |
C0016066 |
Addexbio |
One Frozen vial |
EUR 546 |
H847 cells |
C0016067 |
Addexbio |
One Frozen vial |
EUR 651.6 |