nfkb-p65
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July 27, 2020

Crucial Roles in Thyroid hormone Pancreatic beta cells

By Charles

Transcription issue GLIS3: Crucial roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes

GLI-Comparable 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc finger transcription elements that capabilities as an activator or repressor of gene expression. Examine of GLIS3-deficiency in mice and people revealed that GLIS3 performs a essential function within the regulation of a number of organic processes and is implicated within the growth of assorted illnesses, together with hypothyroidism and diabetes.

This was supported by genome-wide affiliation research that recognized important associations of frequent variants in GLIS3 with elevated threat of those pathologies. To acquire insights into the causal mechanisms underlying these illnesses, it’s crucial to know the mechanisms by which this protein regulates the event of those pathologies. Current research of genes regulated by GLIS3 led to the identification of numerous goal genes and have supplied essential molecular insights by which GLIS3 controls mobile processes.

MEF-2C Polyclonal Antibody

These research revealed that GLIS3 is important for thyroid hormone biosynthesis and recognized a essential operate for GLIS3 within the technology of pancreatic β cells and insulin gene transcription. These observations raised the chance that the GLIS3 signaling pathway may present a possible therapeutic goal within the administration of diabetes, hypothyroidism, and different illnesses.

nfkb-p65

nfkb-p65

To develop such methods, will probably be essential to know the upstream signaling pathways that regulate the exercise, expression and performance of GLIS3. Right here, we assessment the current progress on the molecular mechanisms by which GLIS3 controls key capabilities in thyroid follicular and pancreatic β cells and the way this causally pertains to the event of hypothyroidism and diabetes.

 

 

Platelet microparticles-derived miR-25-3p promotes the hepatocyte proliferation and cell autophagy by way of decreasing B–cell translocation gene 2

 

  • Platelets are vital regulators of liver regeneration, however the mechanisms are nonetheless not totally understood. Platelets have been proven to include all kinds of microRNAs (miRNAs) and play an essential function in lots of illnesses. Nevertheless, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate the hepatocyte proliferation just isn’t very clear. On this research, now we have efficiently remoted and recognized PMPs.
  • We additionally discovered that PMPs, which may very well be nicely built-in into the HHL-5 cells, might upregulate the extent of miR-25-3p in HHL-5 cells. In the meantime, we discovered that PMPs-derived miR-25-3p promoted HHL-5 cells proliferation by accelerating cells into the S part, and enhanced the autophagy by growing the LC3II expression and decreasing the P62 expression.
  • Then, we proved that the miR-25-3p might goal the B-cell translocation gene 2 (BTG2) and downregulate the expression ranges of the BTG2 gene in HHL-5 cells. As well as, the overexpression of BTG2 considerably inhibited the proliferation and autophagy talents of HHL-5 cells, whereas cotransfected miR-25-3p mimics or PMPs might partially rescue HHL-5 cells proliferation and autophagy.
  • Moreover, we proved that PMPs accelerated hepatocyte proliferation by regulating autophagy pathways. Subsequently, PMPs-derived miR-25-3p promoted HHL-5 cell proliferation and autophagy by concentrating on BTG2, which can be a brand new therapeutic methodology for liver regeneration.

DR4 MEF, P3, irradiated, 1 vial of 2^106 cells
ASF-1015 1 vial of 2 x 10^6 cells
EUR 87.97
Description: 6 month

DR4 MEF, P3, irradiated, 5 vial of 2^106 cells
ASF-1016 5 vials of 2 x 10^6 cells
EUR 189.28
Description: 6 month

CF1 MEF, P2, untreated, 1 vial of 1^106 cells
ASF-1201 1 vial of 1 x 10^6 cells
EUR 95.92
Description: 6 month

CF1 MEF, P2, untreated, 3 vials of 1^106 cells
ASF-1202 3 vials of 1 x 10^6 cells
EUR 161.3
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 4^106 cells
ASF-1213 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

CF1 MEF, P3, irradiated, 5 vials of 4^106 cells
ASF-1214 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 2^106 cells
ASF-1215 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

CF1 MEF, P3, irradiated, 8 vials of 2^106 cells
ASF-1216 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 1^106 cells
ASF-1217 1 vial of 1 x 10^6 cells
EUR 69.07
Description: 6 month

Neo resistant MEF, P2, untreated, 1 vial of 1^106 cells
ASF-1101 1 vial of 1 x 10^6 cells
EUR 95.92
Description: 6 month

Neo resistant MEF, P2, untreated, 3 vials of 1^106 cells
ASF-1102 3 vials of 1 x 10^6 cells
EUR 161.3
Description: 6 month

Neo resistant MEF, P3, irradiated, 1 vial of 4^106 cells
ASF-1113 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

Neo resistant MEF, P3, irradiated, 5 vials of 4^106 cells
ASF-1114 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

Neo resistant MEF, P3, irradiated, 1 vial of 2^106 cells
ASF-1115 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

Neo resistant MEF, P3, irradiated, 8 vials of 2^106 cells
ASF-1116 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

anti-Elf4/MEF
YF-PA11546 100 ug
EUR 483.6
Description: Rabbit polyclonal to Elf4/MEF

anti-Elf4/MEF
YF-PA23641 50 ul
EUR 400.8
Description: Mouse polyclonal to Elf4/MEF

DR4 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells
ASF-1023 1 vial of 4 x 10^6 cells
EUR 107.63
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells
ASF-1024 5 vials of 4 x 10^6 cells
EUR 278.48
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells
ASF-1025 1 vial of 2 x 10^6 cells
EUR 87.97
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 5 vial of 2^106 cells
ASF-1026 5 vials of 2 x 10^6 cells
EUR 189.28
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells
ASF-1223 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells
ASF-1224 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells
ASF-1225 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells
ASF-1226 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells
ASF-1123 1 vial of 4 x 10^6 cells
EUR 78.14
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells
ASF-1124 5 vials of 4 x 10^6 cells
EUR 145.43
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells
ASF-1125 1 vial of 2 x 10^6 cells
EUR 73.99
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells
ASF-1126 8 vials of 2 x 10^6 cells
EUR 161.69
Description: 6 month

MEF-2 Polyclonal Antibody
ES2766-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2 Polyclonal Antibody
ES2766-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2B Polyclonal Antibody
ES2767-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2B from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2B Polyclonal Antibody
ES2767-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2B from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 Polyclonal Antibody
ES6219-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 Polyclonal Antibody
ES6219-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 Polyclonal Antibody
ES6220-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2 Polyclonal Antibody
ES6220-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2C Polyclonal Antibody
ES6223-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2C Polyclonal Antibody
ES6223-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2C Polyclonal Antibody
ES6224-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MEF-2C Polyclonal Antibody
ES6224-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MEF-2D Polyclonal Antibody
ES6226-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2D from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2D Polyclonal Antibody
ES6226-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2D from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2 Polyclonal Antibody
41129-100ul 100ul
EUR 302.4

MEF-2 Polyclonal Antibody
41129-50ul 50ul
EUR 224.4

MEF-2 Polyclonal Antibody
41130-100ul 100ul
EUR 302.4

MEF-2 Polyclonal Antibody
41130-50ul 50ul
EUR 224.4

MEF-2C Polyclonal Antibody
41131-100ul 100ul
EUR 302.4

MEF-2C Polyclonal Antibody
41131-50ul 50ul
EUR 224.4

MEF-2 Polyclonal Antibody
ABP55220-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody
ABP55220-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody
ABP55220-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody
ABP55221-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2 Polyclonal Antibody
ABP55221-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2 Polyclonal Antibody
ABP55221-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2C Polyclonal Antibody
ABP55224-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2C Polyclonal Antibody
ABP55224-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2C Polyclonal Antibody
ABP55224-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2D Polyclonal Antibody
ABP55227-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

MEF-2D Polyclonal Antibody
ABP55227-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

MEF-2D Polyclonal Antibody
ABP55227-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

MEF-2 Polyclonal Antibody
ABP51767-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2 Polyclonal Antibody
ABP51767-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2 Polyclonal Antibody
ABP51767-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2B Polyclonal Antibody
ABP51768-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

MEF-2B Polyclonal Antibody
ABP51768-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

MEF-2B Polyclonal Antibody
ABP51768-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

Anti-ELF4/Mef Antibody
A03714 100ul
EUR 476.4
Description: Rabbit Polyclonal ELF4/Mef Antibody. Validated in WB and tested in Human.

Anti-Elf4/MEF Antibody
STJ500867 100 µg
EUR 571.2

Anti-MEF-2 antibody
STJ94063 200 µl
EUR 236.4
Description: Rabbit polyclonal to MEF-2.

Anti-MEF-2 antibody
STJ94064 200 µl
EUR 236.4
Description: Rabbit polyclonal to MEF-2.

Anti-MEF-2 antibody
STJ94065 200 µl
EUR 236.4
Description: Rabbit polyclonal to MEF-2.

Anti-MEF-2B antibody
STJ94066 200 µl
EUR 236.4
Description: Rabbit polyclonal to MEF-2B.

Anti-MEF-2C antibody
STJ94067 200 µl
EUR 236.4
Description: Rabbit polyclonal to MEF-2C.

Anti-MEF-2D antibody
STJ94069 200 µl
EUR 236.4
Description: Rabbit polyclonal to MEF-2D.

Anti-Elf4/MEF (1E10)
YF-MA12828 100 ug
EUR 435.6
Description: Mouse monoclonal to Elf4/MEF

Anti MEF Polyclonal Antibody
KK053 each
EUR 778.8
Description: The Anti MEF Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

MEF-2 Polyclonal Conjugated Antibody
C41129 100ul
EUR 476.4

MEF-2C Polyclonal Conjugated Antibody
C41131 100ul
EUR 476.4

Anti-Elf4/MEF Antibody BIOTIN
STJ500868 100 µg
EUR 703.2

Anti-Elf4/MEF Antibody FITC
STJ500869 100 µg
EUR 703.2

MEF-2 (phospho Ser408) Polyclonal Antibody
ABP50510-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MEF-2 phospho Ser408) from Human, Mouse, Rat. This MEF-2 phospho Ser408) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the phosphorylation site of S408

MEF-2 (phospho Ser408) Polyclonal Antibody
ABP50510-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MEF-2 phospho Ser408) from Human, Mouse, Rat. This MEF-2 phospho Ser408) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the phosphorylation site of S408

MEF-2 (phospho Ser408) Polyclonal Antibody
ABP50510-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MEF-2 phospho Ser408) from Human, Mouse, Rat. This MEF-2 phospho Ser408) antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the phosphorylation site of S408

MEF-2 (phospho Thr319) Polyclonal Antibody
ES1354-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr319) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 (phospho Thr319) Polyclonal Antibody
ES1354-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr319) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 (phospho Ser408) Polyclonal Antibody
ES1509-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Ser408) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2 (phospho Ser408) Polyclonal Antibody
ES1509-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Ser408) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2 (phospho Thr312) Polyclonal Antibody
ES6218-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr312) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

MEF-2 (phospho Thr312) Polyclonal Antibody
ES6218-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr312) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

MEF-2C (phospho Ser396) Polyclonal Antibody
ES6221-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser396) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2C (phospho Ser396) Polyclonal Antibody
ES6221-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser396) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2C (phospho Ser387) Polyclonal Antibody
ES6222-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser387) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MEF-2C (phospho Ser387) Polyclonal Antibody
ES6222-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser387) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MEF-2D (phospho Ser444) Polyclonal Antibody
ES6225-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MEF-2D (phospho Ser444) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2D (phospho Ser444) Polyclonal Antibody
ES6225-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MEF-2D (phospho Ser444) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2D (Phospho-Ser444) Polyclonal Antibody
12205-100ul 100ul
EUR 302.4

 

IL-10-producing B cells play essential function within the pathogenesis of recurrent being pregnant loss

 

Interleukin (IL)-10-producing B cells are lately identified for his or her regulatory operate in a number of issues. Nevertheless, the attainable function of those cells stays unclear in recurrent being pregnant loss (RPL) pathogenesis. Complete B cells from 24 RPL sufferers with mobile immune abnormalities, in addition to that of 25 regular pregnant girls had been cultured and stimulated by Toll Like Receptor (TLR) agonists (CpG oligodeoxynucleotides (ODN) and imiquimod).

TW,96WL,HTS,FEEDER RESERVIOR W/LID,S,BK,10/10

Then, the frequency of IL-10+ CD19+ B cells was came upon utilizing circulate cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the degrees of IL-10 in supernatant medium and serum of stimulated B cells, in addition to these of a number of serum autoantibodies. Actual-Time PCR methodology was carried out for figuring out the IL-10 expression stage and particular genes transcripts. RPL sufferers indicated a decrease proportion of IL-10+ CD19+ B cells, and diminished ranges of IL-10 in each serum and supernatant of the tradition medium of the stimulated B cells.

EZSolution? Puromycin Dihydrochloride

In accordance with the outcomes, whole IgG ranges was better in serum of RPL sufferers compared with wholesome pregnant girls. Equally, the proportion of those cells was negatively correlated with serum whole IgG ranges and the variety of miscarriages. The expression ranges of the mRNA of programmed death-ligand 1 (PD-L1) and IL-10 had been decrease in RPL sufferers, whereas these of x binding protein 1 (XBP-1), interferon regulatory issue 4 (IRF4), and B lymphocyte-induced maturation protein 1 (BLIMP1) had been considerably elevated.

These observations indicated that the discount within the inhabitants of peripheral blood IL-10-synthesizing B cells could immediate RPL pathogenesis, suggesting suppressive results of those cells on autoantibody manufacturing and profitable being pregnant outcomes.

 

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody
20-abx005015
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody
20-abx008443
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Mitotic Checkpoint Protein BUB3 (Bub3) Antibody
abx037779-100ug 100 ug
EUR 469.2

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody
abx230988-100ug 100 ug
EUR 610.8

Mitotic Checkpoint Protein BUB3 (BUB3) Protein
20-abx260818
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody
20-abx329635
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Early Mitotic Inhibitor 2 (EMI2) Antibody
abx432213-200ul 200 ul
EUR 460.8

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody
20-abx317981
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mitotic Checkpoint Protein BUB3 (BUB3) Antibody
20-abx213427
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Nuclear Mitotic Apparatus Protein (NuMA) Antibody
abx235912-100ug 100 ug
EUR 577.2

EMI1 Antibody (Early Mitotic Inhibitor-1)
V7090-100UG 100 ug
EUR 499
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)
V7090-20UG 20 ug
EUR 219
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)
V7090IHC-7ML 7 ml
EUR 499
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)
V7090SAF-100UG 100 ug
EUR 499
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)
V2527-100UG 100 ug
EUR 499
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)
V2527-20UG 20 ug
EUR 219
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)
V2527IHC-7ML 7 ml
EUR 499
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

EMI1 Antibody (Early Mitotic Inhibitor-1)
V2527SAF-100UG 100 ug
EUR 499
Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

5637 cells
C0002001 One Frozen vial
EUR 582

MB49 cells
C0002004 One Frozen vial
EUR 932.4

K562 cells
C0003004 One Frozen vial
EUR 546

U937 cells
C0003005 One Frozen vial
EUR 546

Raji cells
C0003009 One Frozen vial
EUR 546

Daudi cells
C0003010 One Frozen vial
EUR 546

RS4;11 cells
C0003012 One Frozen vial
EUR 546

NAMALWA cells
C0003013 One Frozen vial
EUR 546

BJAB cells
C0003016 One Frozen vial
EUR 651.6

FO cells
C0003017 One Frozen vial
EUR 582

MC116 cells
C0003021 One Frozen vial
EUR 582

P3X63Ag8.653 cells
C0003028 One Frozen vial
EUR 546

REH cells
C0003031 One Frozen vial
EUR 582

Mino cells
C0003033 One Frozen vial
EUR 582

U87MG cells
C0005002 One Frozen vial
EUR 546

B103 cells
C0005003 One Frozen vial
EUR 932.4

T47D cells
C0006001 One Frozen vial
EUR 546

4T1 cells
C0006004 One Frozen vial
EUR 546

HeLa cells
C0008001 One Frozen vial
EUR 546

SiHa cells
C0008002 One Frozen vial
EUR 546

C33A cells
C0008003 One Frozen vial
EUR 546

CaSKi cells
C0008004 One Frozen vial
EUR 546

SW480 cells
C0009001 One Frozen vial
EUR 546

SW620 cells
C0009002 One Frozen vial
EUR 546

T84 cells
C0009008 One Frozen vial
EUR 546

HCT15 cells
C0009010 One Frozen vial
EUR 546

LoVo cells
C0009011 One Frozen vial
EUR 546

RKO cells
C0009012 One Frozen vial
EUR 546

SW48 cells
C0009014 One Frozen vial
EUR 546

SW1116 cells
C0009019 One Frozen vial
EUR 546

H716 cells
C0009022 One Frozen vial
EUR 651.6

OE33 cells
C0013003 One Frozen vial
EUR 792

JROECL33 cells
C0013004 One Frozen vial
EUR 792

Hep3B cells
C0015001 One Frozen vial
EUR 546

HepG2 cells
C0015002 One Frozen vial
EUR 546

Calu3 cells
C0016001 One Frozen vial
EUR 546

A549 cells
C0016002 One Frozen vial
EUR 546

H460 cells
C0016003 One Frozen vial
EUR 546

A427 cells
C0016004 One Frozen vial
EUR 546

H23 cells
C0016005 One Frozen vial
EUR 546

H1703 cells
C0016008 One Frozen vial
EUR 651.6

SW1573 cells
C0016009 One Frozen vial
EUR 651.6

H520 cells
C0016010 One Frozen vial
EUR 546

H226 cells
C0016011 One Frozen vial
EUR 546

HCC4006 cells
C0016012 One Frozen vial
EUR 546

H1975 cells
C0016013 One Frozen vial
EUR 651.6

H1650 cells
C0016015 One Frozen vial
EUR 651.6

H358 cells
C0016016 One Frozen vial
EUR 546

H2228 cells
C0016017 One Frozen vial
EUR 651.6

H2170 cells
C0016018 One Frozen vial
EUR 546

H441 cells
C0016019 One Frozen vial
EUR 546

H596 cells
C0016020 One Frozen vial
EUR 546

H1581 cells
C0016028 One Frozen vial
EUR 651.6

H2444 cells
C0016038 One Frozen vial
EUR 651.6

H69AR cells
C0016046 One Frozen vial
EUR 651.6

H1373 cells
C0016047 One Frozen vial
EUR 651.6

H2122 cells
C0016048 One Frozen vial
EUR 651.6

H526 cells
C0016052 One Frozen vial
EUR 546

H1299 cells
C0016053 One Frozen vial
EUR 546

H446 cells
C0016054 One Frozen vial
EUR 651.6

H1770 cells
C0016057 One Frozen vial
EUR 651.6

H1184 cells
C0016058 One Frozen vial
EUR 651.6

H1694 cells
C0016060 One Frozen vial
EUR 651.6

H187 cells
C0016061 One Frozen vial
EUR 546

H1963 cells
C0016062 One Frozen vial
EUR 651.6

H209 cells
C0016063 One Frozen vial
EUR 546

H69 cells
C0016065 One Frozen vial
EUR 546

H82 cells
C0016066 One Frozen vial
EUR 546

H847 cells
C0016067 One Frozen vial
EUR 651.6
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