nfkb-p65

Transcription issue GLIS3: Crucial roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes

GLI-Comparable 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc finger transcription elements that capabilities as an activator or repressor of gene expression. Examine of GLIS3-deficiency in mice and people revealed that GLIS3 performs a essential function within the regulation of a number of organic processes and is implicated within the growth of assorted illnesses, together with hypothyroidism and diabetes.

This was supported by genome-wide affiliation research that recognized important associations of frequent variants in GLIS3 with elevated threat of those pathologies. To acquire insights into the causal mechanisms underlying these illnesses, it’s crucial to know the mechanisms by which this protein regulates the event of those pathologies. Current research of genes regulated by GLIS3 led to the identification of numerous goal genes and have supplied essential molecular insights by which GLIS3 controls mobile processes.

MEF-2C Polyclonal Antibody

These research revealed that GLIS3 is important for thyroid hormone biosynthesis and recognized a essential operate for GLIS3 within the technology of pancreatic β cells and insulin gene transcription. These observations raised the chance that the GLIS3 signaling pathway may present a possible therapeutic goal within the administration of diabetes, hypothyroidism, and different illnesses.

nfkb-p65

nfkb-p65

To develop such methods, will probably be essential to know the upstream signaling pathways that regulate the exercise, expression and performance of GLIS3. Right here, we assessment the current progress on the molecular mechanisms by which GLIS3 controls key capabilities in thyroid follicular and pancreatic β cells and the way this causally pertains to the event of hypothyroidism and diabetes.

 

 

Platelet microparticles-derived miR-25-3p promotes the hepatocyte proliferation and cell autophagy by way of decreasing Bcell translocation gene 2

 

  • Platelets are vital regulators of liver regeneration, however the mechanisms are nonetheless not totally understood. Platelets have been proven to include all kinds of microRNAs (miRNAs) and play an essential function in lots of illnesses. Nevertheless, the mechanism that how the platelet microparticles (PMPs)-derived miRNA regulate the hepatocyte proliferation just isn’t very clear. On this research, now we have efficiently remoted and recognized PMPs.
  • We additionally discovered that PMPs, which may very well be nicely built-in into the HHL-5 cells, might upregulate the extent of miR-25-3p in HHL-5 cells. In the meantime, we discovered that PMPs-derived miR-25-3p promoted HHL-5 cells proliferation by accelerating cells into the S part, and enhanced the autophagy by growing the LC3II expression and decreasing the P62 expression.
  • Then, we proved that the miR-25-3p might goal the B-cell translocation gene 2 (BTG2) and downregulate the expression ranges of the BTG2 gene in HHL-5 cells. As well as, the overexpression of BTG2 considerably inhibited the proliferation and autophagy talents of HHL-5 cells, whereas cotransfected miR-25-3p mimics or PMPs might partially rescue HHL-5 cells proliferation and autophagy.
  • Moreover, we proved that PMPs accelerated hepatocyte proliferation by regulating autophagy pathways. Subsequently, PMPs-derived miR-25-3p promoted HHL-5 cell proliferation and autophagy by concentrating on BTG2, which can be a brand new therapeutic methodology for liver regeneration.

DR4 MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1015 1 vial of 2 x 10^6 cells
EUR 73.31
Description: 6 month

DR4 MEF, P3, irradiated, 5 vial of 2^106 cells

ASF-1016 5 vials of 2 x 10^6 cells
EUR 157.73
Description: 6 month

CF1 MEF, P2, untreated, 1 vial of 1^106 cells

ASF-1201 1 vial of 1 x 10^6 cells
EUR 79.93
Description: 6 month

CF1 MEF, P2, untreated, 3 vials of 1^106 cells

ASF-1202 3 vials of 1 x 10^6 cells
EUR 134.42
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 4^106 cells

ASF-1213 1 vial of 4 x 10^6 cells
EUR 65.12
Description: 6 month

CF1 MEF, P3, irradiated, 5 vials of 4^106 cells

ASF-1214 5 vials of 4 x 10^6 cells
EUR 121.19
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1215 1 vial of 2 x 10^6 cells
EUR 61.66
Description: 6 month

CF1 MEF, P3, irradiated, 8 vials of 2^106 cells

ASF-1216 8 vials of 2 x 10^6 cells
EUR 134.74
Description: 6 month

CF1 MEF, P3, irradiated, 1 vial of 1^106 cells

ASF-1217 1 vial of 1 x 10^6 cells
EUR 57.56
Description: 6 month

Neo resistant MEF, P2, untreated, 1 vial of 1^106 cells

ASF-1101 1 vial of 1 x 10^6 cells
EUR 79.93
Description: 6 month

Neo resistant MEF, P2, untreated, 3 vials of 1^106 cells

ASF-1102 3 vials of 1 x 10^6 cells
EUR 134.42
Description: 6 month

Neo resistant MEF, P3, irradiated, 1 vial of 4^106 cells

ASF-1113 1 vial of 4 x 10^6 cells
EUR 65.12
Description: 6 month

Neo resistant MEF, P3, irradiated, 5 vials of 4^106 cells

ASF-1114 5 vials of 4 x 10^6 cells
EUR 121.19
Description: 6 month

Neo resistant MEF, P3, irradiated, 1 vial of 2^106 cells

ASF-1115 1 vial of 2 x 10^6 cells
EUR 61.66
Description: 6 month

Neo resistant MEF, P3, irradiated, 8 vials of 2^106 cells

ASF-1116 8 vials of 2 x 10^6 cells
EUR 134.74
Description: 6 month

anti-Elf4/MEF

YF-PA11546 100 ug
EUR 403
Description: Rabbit polyclonal to Elf4/MEF

anti-Elf4/MEF

YF-PA23641 50 ul
EUR 334
Description: Mouse polyclonal to Elf4/MEF

DR4 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1023 1 vial of 4 x 10^6 cells
EUR 89.69
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1024 5 vials of 4 x 10^6 cells
EUR 232.07
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1025 1 vial of 2 x 10^6 cells
EUR 73.31
Description: 6 month

DR4 MEF, P3, mitomycin-C treated, 5 vial of 2^106 cells

ASF-1026 5 vials of 2 x 10^6 cells
EUR 157.73
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1223 1 vial of 4 x 10^6 cells
EUR 65.12
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1224 5 vials of 4 x 10^6 cells
EUR 121.19
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1225 1 vial of 2 x 10^6 cells
EUR 61.66
Description: 6 month

CF1 MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells

ASF-1226 8 vials of 2 x 10^6 cells
EUR 134.74
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 4^106 cells

ASF-1123 1 vial of 4 x 10^6 cells
EUR 65.12
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 5 vials of 4^106 cells

ASF-1124 5 vials of 4 x 10^6 cells
EUR 121.19
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 1 vial of 2^106 cells

ASF-1125 1 vial of 2 x 10^6 cells
EUR 61.66
Description: 6 month

Neo resistant MEF, P3, mitomycin-C treated, 8 vials of 2^106 cells

ASF-1126 8 vials of 2 x 10^6 cells
EUR 134.74
Description: 6 month

MEF-2 Polyclonal Antibody

ES6219-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 Polyclonal Antibody

ES6219-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 Polyclonal Antibody

ES6220-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2 Polyclonal Antibody

ES6220-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2C Polyclonal Antibody

ES6223-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2C Polyclonal Antibody

ES6223-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2C Polyclonal Antibody

ES6224-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MEF-2C Polyclonal Antibody

ES6224-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2C from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MEF-2D Polyclonal Antibody

ES6226-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2D from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2D Polyclonal Antibody

ES6226-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2D from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

MEF-2 Polyclonal Antibody

ES2766-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2 Polyclonal Antibody

ES2766-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2B Polyclonal Antibody

ES2767-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2B from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2B Polyclonal Antibody

ES2767-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2B from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Anti-Elf4/MEF Antibody

STJ500867 100 µg
EUR 476

Anti MEF Polyclonal Antibody

KK053
EUR 649
Description: The Anti MEF Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

Anti-ELF4/Mef Antibody

A03714 100ul
EUR 397
Description: Rabbit Polyclonal ELF4/Mef Antibody. Validated in WB and tested in Human.

MEF-2 Polyclonal Antibody

ABP51767-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2 Polyclonal Antibody

ABP51767-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2 Polyclonal Antibody

ABP51767-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of S408

MEF-2B Polyclonal Antibody

ABP51768-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

MEF-2B Polyclonal Antibody

ABP51768-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

MEF-2B Polyclonal Antibody

ABP51768-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of MEF-2B from Human, Mouse. This MEF-2B antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MEF-2B at AA range: 30-110

MEF-2 Polyclonal Antibody

ABP55220-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody

ABP55220-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody

ABP55220-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T312

MEF-2 Polyclonal Antibody

ABP55221-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2 Polyclonal Antibody

ABP55221-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2 Polyclonal Antibody

ABP55221-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of MEF-2 from Human, Mouse, Rat. This MEF-2 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the non-phosphorylation site of T319

MEF-2C Polyclonal Antibody

ABP55224-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2C Polyclonal Antibody

ABP55224-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2C Polyclonal Antibody

ABP55224-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of MEF-2C from Human, Mouse. This MEF-2C antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2C around the non-phosphorylation site of S396

MEF-2D Polyclonal Antibody

ABP55227-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

MEF-2D Polyclonal Antibody

ABP55227-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

MEF-2D Polyclonal Antibody

ABP55227-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of MEF-2D from Human, Mouse, Rat. This MEF-2D antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2D around the non-phosphorylation site of S444

Anti-MEF-2 antibody

STJ94063 200 µl
EUR 197
Description: Rabbit polyclonal to MEF-2.

Anti-MEF-2 antibody

STJ94064 200 µl
EUR 197
Description: Rabbit polyclonal to MEF-2.

Anti-MEF-2 antibody

STJ94065 200 µl
EUR 197
Description: Rabbit polyclonal to MEF-2.

Anti-MEF-2B antibody

STJ94066 200 µl
EUR 197
Description: Rabbit polyclonal to MEF-2B.

Anti-MEF-2C antibody

STJ94067 200 µl
EUR 197
Description: Rabbit polyclonal to MEF-2C.

Anti-MEF-2D antibody

STJ94069 200 µl
EUR 197
Description: Rabbit polyclonal to MEF-2D.

MEF-2 Polyclonal Antibody

41129-100ul 100ul
EUR 252

MEF-2 Polyclonal Antibody

41129-50ul 50ul
EUR 187

MEF-2 Polyclonal Antibody

41130-100ul 100ul
EUR 252

MEF-2 Polyclonal Antibody

41130-50ul 50ul
EUR 187

MEF-2C Polyclonal Antibody

41131-100ul 100ul
EUR 252

MEF-2C Polyclonal Antibody

41131-50ul 50ul
EUR 187

Anti-Elf4/MEF (1E10)

YF-MA12828 100 ug
EUR 363
Description: Mouse monoclonal to Elf4/MEF

Anti-Elf4/MEF Antibody BIOTIN

STJ500868 100 µg
EUR 586

Anti-Elf4/MEF Antibody FITC

STJ500869 100 µg
EUR 586

MEF-2 Polyclonal Conjugated Antibody

C41129 100ul
EUR 397

MEF-2C Polyclonal Conjugated Antibody

C41131 100ul
EUR 397

MEF-2 (phospho Thr312) Polyclonal Antibody

ES6218-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr312) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

MEF-2 (phospho Thr312) Polyclonal Antibody

ES6218-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr312) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

MEF-2C (phospho Ser396) Polyclonal Antibody

ES6221-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser396) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2C (phospho Ser396) Polyclonal Antibody

ES6221-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser396) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2C (phospho Ser387) Polyclonal Antibody

ES6222-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser387) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MEF-2C (phospho Ser387) Polyclonal Antibody

ES6222-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2C (phospho Ser387) from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MEF-2D (phospho Ser444) Polyclonal Antibody

ES6225-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2D (phospho Ser444) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2D (phospho Ser444) Polyclonal Antibody

ES6225-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2D (phospho Ser444) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 (phospho Thr319) Polyclonal Antibody

ES1354-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr319) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 (phospho Ser408) Polyclonal Antibody

ES1509-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Ser408) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2 (phospho Thr319) Polyclonal Antibody

ES1354-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Thr319) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

MEF-2 (phospho Ser408) Polyclonal Antibody

ES1509-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MEF-2 (phospho Ser408) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MEF-2D (Phospho-Ser444) Polyclonal Antibody

12205-100ul 100ul
EUR 252

MEF-2D (Phospho-Ser444) Polyclonal Antibody

12205-50ul 50ul
EUR 187

MEF-2 (phospho Thr319) Polyclonal Antibody

ABP50355-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of MEF-2 phospho Thr319) from Human, Mouse, Rat. This MEF-2 phospho Thr319) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the phosphorylation site of T319

MEF-2 (phospho Thr319) Polyclonal Antibody

ABP50355-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of MEF-2 phospho Thr319) from Human, Mouse, Rat. This MEF-2 phospho Thr319) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human MEF-2 around the phosphorylation site of T319

 

IL-10-producing B cells play essential function within the pathogenesis of recurrent being pregnant loss

 

Interleukin (IL)-10-producing B cells are lately identified for his or her regulatory operate in a number of issues. Nevertheless, the attainable function of those cells stays unclear in recurrent being pregnant loss (RPL) pathogenesis. Complete B cells from 24 RPL sufferers with mobile immune abnormalities, in addition to that of 25 regular pregnant girls had been cultured and stimulated by Toll Like Receptor (TLR) agonists (CpG oligodeoxynucleotides (ODN) and imiquimod).

TW,96WL,HTS,FEEDER RESERVIOR W/LID,S,BK,10/10

Then, the frequency of IL-10+ CD19+ B cells was came upon utilizing circulate cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate the degrees of IL-10 in supernatant medium and serum of stimulated B cells, in addition to these of a number of serum autoantibodies. Actual-Time PCR methodology was carried out for figuring out the IL-10 expression stage and particular genes transcripts. RPL sufferers indicated a decrease proportion of IL-10+ CD19+ B cells, and diminished ranges of IL-10 in each serum and supernatant of the tradition medium of the stimulated B cells.

EZSolution? Puromycin Dihydrochloride

In accordance with the outcomes, whole IgG ranges was better in serum of RPL sufferers compared with wholesome pregnant girls. Equally, the proportion of those cells was negatively correlated with serum whole IgG ranges and the variety of miscarriages. The expression ranges of the mRNA of programmed death-ligand 1 (PD-L1) and IL-10 had been decrease in RPL sufferers, whereas these of x binding protein 1 (XBP-1), interferon regulatory issue 4 (IRF4), and B lymphocyte-induced maturation protein 1 (BLIMP1) had been considerably elevated.

These observations indicated that the discount within the inhabitants of peripheral blood IL-10-synthesizing B cells could immediate RPL pathogenesis, suggesting suppressive results of those cells on autoantibody manufacturing and profitable being pregnant outcomes.

 

STO cells

P0011006 One Frozen vial
EUR 455

A9 cells

P0011007 One Frozen vial
EUR 543

L929 cells

P0011012 One Frozen vial
EUR 455

MDCKII cells

P0014001 One Frozen vial
EUR 455

VERO cells

P0014002 One Frozen vial
EUR 455

MDCK cells

P0014003 One Frozen vial
EUR 455

BJ cells

P0020005 One Frozen vial
EUR 455

HUVEC cells

P0027001 One Frozen vial
EUR 485

C2C12 cells

P0028001 One Frozen vial
EUR 455

ST cells

P0028002 One Frozen vial
EUR 543

hFOB1.19 cells

T0004005 One Frozen vial
EUR 455

SVGp12 cells

T0005008 One Frozen vial
EUR 543

BSC40 cells

T0011003 One Frozen vial
EUR 543

Mv1Lu cells

T0016003 One Frozen vial
EUR 455

IMCC3 cells

T0017001 One Frozen vial
EUR 719

HPDEC cells

T0018001 One Frozen vial
EUR 777

HaCaT cells

T0020001 One Frozen vial
EUR 719

Hs27 cells

T0020010 One Frozen vial
EUR 455

TM3 cells

T0028002 One Frozen vial
EUR 455

5637 cells

C0002001 One Frozen vial
EUR 485

MB49 cells

C0002004 One Frozen vial
EUR 777

K562 cells

C0003004 One Frozen vial
EUR 455

U937 cells

C0003005 One Frozen vial
EUR 455

Raji cells

C0003009 One Frozen vial
EUR 455

Daudi cells

C0003010 One Frozen vial
EUR 455

RS4;11 cells

C0003012 One Frozen vial
EUR 455

NAMALWA cells

C0003013 One Frozen vial
EUR 455

BJAB cells

C0003016 One Frozen vial
EUR 543

FO cells

C0003017 One Frozen vial
EUR 485

MC116 cells

C0003021 One Frozen vial
EUR 485

P3X63Ag8.653 cells

C0003028 One Frozen vial
EUR 455

REH cells

C0003031 One Frozen vial
EUR 485

Mino cells

C0003033 One Frozen vial
EUR 485

U87MG cells

C0005002 One Frozen vial
EUR 455

B103 cells

C0005003 One Frozen vial
EUR 777

T47D cells

C0006001 One Frozen vial
EUR 455

4T1 cells

C0006004 One Frozen vial
EUR 455

HeLa cells

C0008001 One Frozen vial
EUR 455

SiHa cells

C0008002 One Frozen vial
EUR 455

C33A cells

C0008003 One Frozen vial
EUR 455

CaSKi cells

C0008004 One Frozen vial
EUR 455

SW480 cells

C0009001 One Frozen vial
EUR 455

SW620 cells

C0009002 One Frozen vial
EUR 455

T84 cells

C0009008 One Frozen vial
EUR 455

HCT15 cells

C0009010 One Frozen vial
EUR 455

LoVo cells

C0009011 One Frozen vial
EUR 455

RKO cells

C0009012 One Frozen vial
EUR 455

SW48 cells

C0009014 One Frozen vial
EUR 455

SW1116 cells

C0009019 One Frozen vial
EUR 455

H716 cells

C0009022 One Frozen vial
EUR 543

OE33 cells

C0013003 One Frozen vial
EUR 660

JROECL33 cells

C0013004 One Frozen vial
EUR 660

Hep3B cells

C0015001 One Frozen vial
EUR 455

HepG2 cells

C0015002 One Frozen vial
EUR 455

Calu3 cells

C0016001 One Frozen vial
EUR 455

A549 cells

C0016002 One Frozen vial
EUR 455

H460 cells

C0016003 One Frozen vial
EUR 455

A427 cells

C0016004 One Frozen vial
EUR 455

H23 cells

C0016005 One Frozen vial
EUR 455

H1703 cells

C0016008 One Frozen vial
EUR 543

SW1573 cells

C0016009 One Frozen vial
EUR 543

H520 cells

C0016010 One Frozen vial
EUR 455

H226 cells

C0016011 One Frozen vial
EUR 455

HCC4006 cells

C0016012 One Frozen vial
EUR 455

H1975 cells

C0016013 One Frozen vial
EUR 543

H1650 cells

C0016015 One Frozen vial
EUR 543

H358 cells

C0016016 One Frozen vial
EUR 455

H2228 cells

C0016017 One Frozen vial
EUR 543

H2170 cells

C0016018 One Frozen vial
EUR 455

H441 cells

C0016019 One Frozen vial
EUR 455

H596 cells

C0016020 One Frozen vial
EUR 455

H1581 cells

C0016028 One Frozen vial
EUR 543

H2444 cells

C0016038 One Frozen vial
EUR 543

H69AR cells

C0016046 One Frozen vial
EUR 543

H1373 cells

C0016047 One Frozen vial
EUR 543

H2122 cells

C0016048 One Frozen vial
EUR 543

H526 cells

C0016052 One Frozen vial
EUR 455

H1299 cells

C0016053 One Frozen vial
EUR 455

H446 cells

C0016054 One Frozen vial
EUR 543

H1770 cells

C0016057 One Frozen vial
EUR 543

H1184 cells

C0016058 One Frozen vial
EUR 543

H1694 cells

C0016060 One Frozen vial
EUR 543

H187 cells

C0016061 One Frozen vial
EUR 455

H1963 cells

C0016062 One Frozen vial
EUR 543

H209 cells

C0016063 One Frozen vial
EUR 455

H69 cells

C0016065 One Frozen vial
EUR 455

H82 cells

C0016066 One Frozen vial
EUR 455